Review of research progress on detection methods for CD4+ T lymphocytes infected with HIV
CD4+ T lymphocytes are an important part of human immune cells and the main target cells of human immunodeficiency virus (HIV) infection. Acquired immune deficiency syndrome (AIDS) is a chronic infectious disease that usually takes 2–8 years from infection to onset. Research has found that only a sm...
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Open Exploration Publishing Inc.
2025-07-01
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| Series: | Exploration of Medicine |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A1001348/1001348.pdf |
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| author | Zhimin Huang Xiaohui Wang |
| author_facet | Zhimin Huang Xiaohui Wang |
| author_sort | Zhimin Huang |
| collection | DOAJ |
| description | CD4+ T lymphocytes are an important part of human immune cells and the main target cells of human immunodeficiency virus (HIV) infection. Acquired immune deficiency syndrome (AIDS) is a chronic infectious disease that usually takes 2–8 years from infection to onset. Research has found that only a small number of CD4+ T cells in HIV infected individuals are in an HIV infected state, and the dynamic changes of HIV-infected CD4+ T lymphocytes (HICTLs) at different stages of HIV infection are still unclear. Meanwhile, HICTLs are the source of the HIV reservoir. Therefore, analyzing the percentage and dynamic changes of infected cells in infected individuals is of great significance for AIDS research. However, due to the high variability of the HIV gene and the lack of highly sensitive detection methods, the standard method for distinguishing HIV infected and uninfected CD4+ T cells has not been established so far. This article summarizes the markers and detection methods of HICTLs at present. |
| format | Article |
| id | doaj-art-999010b3f57346b3a680fdf7bf2d4ab1 |
| institution | Kabale University |
| issn | 2692-3106 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Medicine |
| spelling | doaj-art-999010b3f57346b3a680fdf7bf2d4ab12025-08-20T03:36:12ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062025-07-016100134810.37349/emed.2025.1001348Review of research progress on detection methods for CD4+ T lymphocytes infected with HIVZhimin Huang0https://orcid.org/0009-0001-2072-8248Xiaohui Wang1https://orcid.org/0000-0002-8683-7180Medical Laboratory Center, Shenzhen Luohu District People’s Hospital, Shenzhen 518005, Guangdong, China; Department of HIV/AIDS Prevention and Control, Shenzhen Center for Disease Control and Prevention, Shenzhen 518020, Guangdong, ChinaDepartment of HIV/AIDS Prevention and Control, Shenzhen Center for Disease Control and Prevention, Shenzhen 518020, Guangdong, ChinaCD4+ T lymphocytes are an important part of human immune cells and the main target cells of human immunodeficiency virus (HIV) infection. Acquired immune deficiency syndrome (AIDS) is a chronic infectious disease that usually takes 2–8 years from infection to onset. Research has found that only a small number of CD4+ T cells in HIV infected individuals are in an HIV infected state, and the dynamic changes of HIV-infected CD4+ T lymphocytes (HICTLs) at different stages of HIV infection are still unclear. Meanwhile, HICTLs are the source of the HIV reservoir. Therefore, analyzing the percentage and dynamic changes of infected cells in infected individuals is of great significance for AIDS research. However, due to the high variability of the HIV gene and the lack of highly sensitive detection methods, the standard method for distinguishing HIV infected and uninfected CD4+ T cells has not been established so far. This article summarizes the markers and detection methods of HICTLs at present.https://www.explorationpub.com/uploads/Article/A1001348/1001348.pdfhuman immunodeficiency virushuman immunodeficiency virus-infected cd4+ t cellshuman immunodeficiency virus detection markersdetection method |
| spellingShingle | Zhimin Huang Xiaohui Wang Review of research progress on detection methods for CD4+ T lymphocytes infected with HIV Exploration of Medicine human immunodeficiency virus human immunodeficiency virus-infected cd4+ t cells human immunodeficiency virus detection markers detection method |
| title | Review of research progress on detection methods for CD4+ T lymphocytes infected with HIV |
| title_full | Review of research progress on detection methods for CD4+ T lymphocytes infected with HIV |
| title_fullStr | Review of research progress on detection methods for CD4+ T lymphocytes infected with HIV |
| title_full_unstemmed | Review of research progress on detection methods for CD4+ T lymphocytes infected with HIV |
| title_short | Review of research progress on detection methods for CD4+ T lymphocytes infected with HIV |
| title_sort | review of research progress on detection methods for cd4 t lymphocytes infected with hiv |
| topic | human immunodeficiency virus human immunodeficiency virus-infected cd4+ t cells human immunodeficiency virus detection markers detection method |
| url | https://www.explorationpub.com/uploads/Article/A1001348/1001348.pdf |
| work_keys_str_mv | AT zhiminhuang reviewofresearchprogressondetectionmethodsforcd4tlymphocytesinfectedwithhiv AT xiaohuiwang reviewofresearchprogressondetectionmethodsforcd4tlymphocytesinfectedwithhiv |