The association between a body shape index and diabetic kidney disease in early-onset type 2 diabetes: evidence from a two-center study
BackgroundEarly-onset type 2 diabetes mellitus (T2DM) is closely associated with an increased risk of diabetic kidney disease (DKD), and obesity is a well-recognized contributing factor. Traditional measures like body mass index (BMI) have limitations in capturing visceral fat distribution. The A Bo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1553890/full |
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| author | Mengdie Chen Yiyun Wang Ping Feng Lijing Wu Hanying Liu Yao Liang Mengyao Yang Qidong Zheng |
| author_facet | Mengdie Chen Yiyun Wang Ping Feng Lijing Wu Hanying Liu Yao Liang Mengyao Yang Qidong Zheng |
| author_sort | Mengdie Chen |
| collection | DOAJ |
| description | BackgroundEarly-onset type 2 diabetes mellitus (T2DM) is closely associated with an increased risk of diabetic kidney disease (DKD), and obesity is a well-recognized contributing factor. Traditional measures like body mass index (BMI) have limitations in capturing visceral fat distribution. The A Body Shape Index (ABSI), a newer anthropometric indicator, may provide a more accurate assessment of central obesity. This study investigated the relationship between ABSI and DKD in individuals with early-onset T2DM.MethodsThis cross-sectional study analyzed data from 2,598 patients with early-onset T2DM enrolled at the National Metabolic Management Centers of Yuhuan Second People’s Hospital and Taizhou Central Hospital between 2017 and 2024. Multivariate logistic regression models were used to evaluate the association between ABSI and DKD, with additional analyses using restricted cubic splines (RCS) to explore dose-response patterns. Subgroup and interaction analyses were also performed.ResultsOf the participants, 1,030 (39.6%) were diagnosed with DKD. The prevalence of DKD increased across ABSI tertiles: 35.8% in the lowest tertile (T1), 38.5% in the middle tertile (T2), and 44.7% in the highest tertile (T3) (P < 0.001). Higher ABSI was independently associated with a greater risk of DKD (OR = 1.24; 95% CI: 1.05–1.50; P = 0.022) after adjusting for potential confounders. Patients in the highest ABSI tertile had a significantly higher risk of DKD than those in the lowest tertile (OR = 1.24; 95% CI: 1.01–1.52; P = 0.041). RCS analysis showed a positive linear relationship between ABSI and DKD risk (P for non-linearity = 0.139), and the findings were consistent across subgroups.ConclusionABSI is positively and linearly associated with the risk of DKD in patients with early-onset T2DM. This metric may be useful for identifying individuals at higher risk and guiding early preventive strategies. |
| format | Article |
| id | doaj-art-9986ee55fc1d4cfb887fe739e24b7ae1 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-9986ee55fc1d4cfb887fe739e24b7ae12025-08-20T03:22:00ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-06-011610.3389/fendo.2025.15538901553890The association between a body shape index and diabetic kidney disease in early-onset type 2 diabetes: evidence from a two-center studyMengdie Chen0Yiyun Wang1Ping Feng2Lijing Wu3Hanying Liu4Yao Liang5Mengyao Yang6Qidong Zheng7Department of Endocrinology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, ChinaDepartment of Internal Medicine, Yuhuan Second People’s Hospital, Yuhuan, ChinaDepartment of Endocrinology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, ChinaDepartment of Internal Medicine, Yuhuan Second People’s Hospital, Yuhuan, ChinaDepartment of Endocrinology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, ChinaDepartment of Internal Medicine, Yuhuan Second People’s Hospital, Yuhuan, ChinaDepartment of Internal Medicine, Yuhuan Second People’s Hospital, Yuhuan, ChinaDepartment of Internal Medicine, Yuhuan Second People’s Hospital, Yuhuan, ChinaBackgroundEarly-onset type 2 diabetes mellitus (T2DM) is closely associated with an increased risk of diabetic kidney disease (DKD), and obesity is a well-recognized contributing factor. Traditional measures like body mass index (BMI) have limitations in capturing visceral fat distribution. The A Body Shape Index (ABSI), a newer anthropometric indicator, may provide a more accurate assessment of central obesity. This study investigated the relationship between ABSI and DKD in individuals with early-onset T2DM.MethodsThis cross-sectional study analyzed data from 2,598 patients with early-onset T2DM enrolled at the National Metabolic Management Centers of Yuhuan Second People’s Hospital and Taizhou Central Hospital between 2017 and 2024. Multivariate logistic regression models were used to evaluate the association between ABSI and DKD, with additional analyses using restricted cubic splines (RCS) to explore dose-response patterns. Subgroup and interaction analyses were also performed.ResultsOf the participants, 1,030 (39.6%) were diagnosed with DKD. The prevalence of DKD increased across ABSI tertiles: 35.8% in the lowest tertile (T1), 38.5% in the middle tertile (T2), and 44.7% in the highest tertile (T3) (P < 0.001). Higher ABSI was independently associated with a greater risk of DKD (OR = 1.24; 95% CI: 1.05–1.50; P = 0.022) after adjusting for potential confounders. Patients in the highest ABSI tertile had a significantly higher risk of DKD than those in the lowest tertile (OR = 1.24; 95% CI: 1.01–1.52; P = 0.041). RCS analysis showed a positive linear relationship between ABSI and DKD risk (P for non-linearity = 0.139), and the findings were consistent across subgroups.ConclusionABSI is positively and linearly associated with the risk of DKD in patients with early-onset T2DM. This metric may be useful for identifying individuals at higher risk and guiding early preventive strategies.https://www.frontiersin.org/articles/10.3389/fendo.2025.1553890/fulla body shape indexvisceral obesitytype 2 diabetesdiabetic kidney diseaseearly-onset |
| spellingShingle | Mengdie Chen Yiyun Wang Ping Feng Lijing Wu Hanying Liu Yao Liang Mengyao Yang Qidong Zheng The association between a body shape index and diabetic kidney disease in early-onset type 2 diabetes: evidence from a two-center study Frontiers in Endocrinology a body shape index visceral obesity type 2 diabetes diabetic kidney disease early-onset |
| title | The association between a body shape index and diabetic kidney disease in early-onset type 2 diabetes: evidence from a two-center study |
| title_full | The association between a body shape index and diabetic kidney disease in early-onset type 2 diabetes: evidence from a two-center study |
| title_fullStr | The association between a body shape index and diabetic kidney disease in early-onset type 2 diabetes: evidence from a two-center study |
| title_full_unstemmed | The association between a body shape index and diabetic kidney disease in early-onset type 2 diabetes: evidence from a two-center study |
| title_short | The association between a body shape index and diabetic kidney disease in early-onset type 2 diabetes: evidence from a two-center study |
| title_sort | association between a body shape index and diabetic kidney disease in early onset type 2 diabetes evidence from a two center study |
| topic | a body shape index visceral obesity type 2 diabetes diabetic kidney disease early-onset |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1553890/full |
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