The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners
The DMT1 gene encodes divalent metal transporter 1, a membrane iron transport protein. Divalent metal transporter 1 influences cellular iron availability, which might further affect aerobic exercise capacity. Short tandem repeat (STR) polymorphisms have been used as genetic markers in the literature...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2019/7064703 |
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| _version_ | 1849404139867471872 |
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| author | Gerile Wuyun Yang Hu Zihong He Yanchun Li Xu Yan |
| author_facet | Gerile Wuyun Yang Hu Zihong He Yanchun Li Xu Yan |
| author_sort | Gerile Wuyun |
| collection | DOAJ |
| description | The DMT1 gene encodes divalent metal transporter 1, a membrane iron transport protein. Divalent metal transporter 1 influences cellular iron availability, which might further affect aerobic exercise capacity. Short tandem repeat (STR) polymorphisms have been used as genetic markers in the literature, yet the STR polymorphisms of the DMT1 gene have not been well studied. In this current study, we explored the polymorphisms of the DMT1 gene in a group of elite long-distance runners and controls, by using the PCR-RFLP (Restriction Fragment Length Polymorphism) and Gene scan technology. We found that the genotype frequency of the homozygous 258 bp STR polymorphism of the DMT1 gene (258 bp/258 bp) was significantly higher in the athlete group than in the controls (χ2=14.01, p=0.006) so does the allele frequency of the 258 bp STR polymorphism (χ2=12.867, p=0.008). These data suggested that the STR polymorphism of the DMT1 gene might be correlated with aerobic exercise capacity and the 258 bp homozygous (25 bp/258 bp) could be used as a molecular marker for the talent identification of elite long-distance runners. |
| format | Article |
| id | doaj-art-9986ed2daf9e474b9b68a890e9d43036 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-9986ed2daf9e474b9b68a890e9d430362025-08-20T03:37:05ZengWileyInternational Journal of Genomics2314-436X2314-43782019-01-01201910.1155/2019/70647037064703The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance RunnersGerile Wuyun0Yang Hu1Zihong He2Yanchun Li3Xu Yan4Institute of Sport, Inner Mongolia Normal University, ChinaChina Institute of Sport and Health Science, Beijing Sport University, ChinaBiology Center, China Institute of Sport Science, ChinaChina Institute of Sport and Health Science, Beijing Sport University, ChinaInstitute for Health and Sport, Victoria University, AustraliaThe DMT1 gene encodes divalent metal transporter 1, a membrane iron transport protein. Divalent metal transporter 1 influences cellular iron availability, which might further affect aerobic exercise capacity. Short tandem repeat (STR) polymorphisms have been used as genetic markers in the literature, yet the STR polymorphisms of the DMT1 gene have not been well studied. In this current study, we explored the polymorphisms of the DMT1 gene in a group of elite long-distance runners and controls, by using the PCR-RFLP (Restriction Fragment Length Polymorphism) and Gene scan technology. We found that the genotype frequency of the homozygous 258 bp STR polymorphism of the DMT1 gene (258 bp/258 bp) was significantly higher in the athlete group than in the controls (χ2=14.01, p=0.006) so does the allele frequency of the 258 bp STR polymorphism (χ2=12.867, p=0.008). These data suggested that the STR polymorphism of the DMT1 gene might be correlated with aerobic exercise capacity and the 258 bp homozygous (25 bp/258 bp) could be used as a molecular marker for the talent identification of elite long-distance runners.http://dx.doi.org/10.1155/2019/7064703 |
| spellingShingle | Gerile Wuyun Yang Hu Zihong He Yanchun Li Xu Yan The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners International Journal of Genomics |
| title | The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners |
| title_full | The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners |
| title_fullStr | The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners |
| title_full_unstemmed | The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners |
| title_short | The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners |
| title_sort | short tandem repeat of the dmt1 gene as a molecular marker of elite long distance runners |
| url | http://dx.doi.org/10.1155/2019/7064703 |
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