The Nephroprotective Effect of Andrographis Paniculata Ethanol Extract Chitosan Nanoparticles on Vero cells
Nephroprotective agents are substances that protect the kidneys from nephrotoxicity. Some nephroprotective agents are derived from medicinal plants. Sambiloto (Andrographis paniculata) is one of the herbal plants known to have a nephroprotective effect. This study aims to determine the nephroprotect...
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| Language: | English |
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EDP Sciences
2025-01-01
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| Series: | E3S Web of Conferences |
| Online Access: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2025/09/e3sconf_icma-sure2024_04006.pdf |
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| author | Wahyu Kurniawan Dhadhang Nabilah Nuryanti Novrial Dody Aries Nurulita Nunuk |
| author_facet | Wahyu Kurniawan Dhadhang Nabilah Nuryanti Novrial Dody Aries Nurulita Nunuk |
| author_sort | Wahyu Kurniawan Dhadhang |
| collection | DOAJ |
| description | Nephroprotective agents are substances that protect the kidneys from nephrotoxicity. Some nephroprotective agents are derived from medicinal plants. Sambiloto (Andrographis paniculata) is one of the herbal plants known to have a nephroprotective effect. This study aims to determine the nephroprotective potential of chitosan-based ethanol extract nanoparticles of Andrographis paniculata on the Vero cell line. Andrographis paniculata ethanol extract nanoparticles were prepared using ionic gelation. These nanoparticles exhibited a viability percentage ranging from 97.251% to 107.258% at concentrations of 50-1000 ppm. In the acute protective test, Andrographis paniculata ethanol extract nanoparticles at a chitosan-based concentration of 500 ppm showed a protective ability of 3.26%. In the recovery test, they exhibited a recovery ability ranging from 4.35% to 21.01% at concentrations of 100-500 ppm, and in the chronic protection test, the recovery ability ranged from 5.01% to 14.24% at concentrations of 100-500 ppm. Chitosan-based ethanol extract nanoparticles of Andrographis paniculata are non-toxic and have nephroprotective abilities in both recovery and protection tests. |
| format | Article |
| id | doaj-art-9986ba6016e04811bcb75a13b149a656 |
| institution | Kabale University |
| issn | 2267-1242 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj-art-9986ba6016e04811bcb75a13b149a6562025-02-05T10:49:56ZengEDP SciencesE3S Web of Conferences2267-12422025-01-016090400610.1051/e3sconf/202560904006e3sconf_icma-sure2024_04006The Nephroprotective Effect of Andrographis Paniculata Ethanol Extract Chitosan Nanoparticles on Vero cellsWahyu Kurniawan Dhadhang0Nabilah1Nuryanti2Novrial Dody3Aries Nurulita Nunuk4Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman, PurwokertoDepartment of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman, PurwokertoDepartment of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman, PurwokertoFaculty of Medicine, Universitas Jenderal Soedirman, PurwokertoFaculty of Pharmacy, Universitas Muhammadiyah PurwokertoNephroprotective agents are substances that protect the kidneys from nephrotoxicity. Some nephroprotective agents are derived from medicinal plants. Sambiloto (Andrographis paniculata) is one of the herbal plants known to have a nephroprotective effect. This study aims to determine the nephroprotective potential of chitosan-based ethanol extract nanoparticles of Andrographis paniculata on the Vero cell line. Andrographis paniculata ethanol extract nanoparticles were prepared using ionic gelation. These nanoparticles exhibited a viability percentage ranging from 97.251% to 107.258% at concentrations of 50-1000 ppm. In the acute protective test, Andrographis paniculata ethanol extract nanoparticles at a chitosan-based concentration of 500 ppm showed a protective ability of 3.26%. In the recovery test, they exhibited a recovery ability ranging from 4.35% to 21.01% at concentrations of 100-500 ppm, and in the chronic protection test, the recovery ability ranged from 5.01% to 14.24% at concentrations of 100-500 ppm. Chitosan-based ethanol extract nanoparticles of Andrographis paniculata are non-toxic and have nephroprotective abilities in both recovery and protection tests.https://www.e3s-conferences.org/articles/e3sconf/pdf/2025/09/e3sconf_icma-sure2024_04006.pdf |
| spellingShingle | Wahyu Kurniawan Dhadhang Nabilah Nuryanti Novrial Dody Aries Nurulita Nunuk The Nephroprotective Effect of Andrographis Paniculata Ethanol Extract Chitosan Nanoparticles on Vero cells E3S Web of Conferences |
| title | The Nephroprotective Effect of Andrographis Paniculata Ethanol Extract Chitosan Nanoparticles on Vero cells |
| title_full | The Nephroprotective Effect of Andrographis Paniculata Ethanol Extract Chitosan Nanoparticles on Vero cells |
| title_fullStr | The Nephroprotective Effect of Andrographis Paniculata Ethanol Extract Chitosan Nanoparticles on Vero cells |
| title_full_unstemmed | The Nephroprotective Effect of Andrographis Paniculata Ethanol Extract Chitosan Nanoparticles on Vero cells |
| title_short | The Nephroprotective Effect of Andrographis Paniculata Ethanol Extract Chitosan Nanoparticles on Vero cells |
| title_sort | nephroprotective effect of andrographis paniculata ethanol extract chitosan nanoparticles on vero cells |
| url | https://www.e3s-conferences.org/articles/e3sconf/pdf/2025/09/e3sconf_icma-sure2024_04006.pdf |
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