miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma
Reactive oxygen species (ROS) are intermediates in oxidation–reduction reactions with the capacity to modify biomolecules and temporarily or permanently alter cell behaviour through signalling pathways under physiological and pathophysiological conditions where there is an imbalance between oxidativ...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/13/11/1326 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850267666633195520 |
|---|---|
| author | José Daniel Escobar Moreno José Luis Fajardo Castiblanco Laura Camila Riaño Rodriguez Paula Marcela Barrios Ospina Carlos Andrés Zabala Bello Esther Natalia Muñoz Roa Hernán Mauricio Rivera Escobar |
| author_facet | José Daniel Escobar Moreno José Luis Fajardo Castiblanco Laura Camila Riaño Rodriguez Paula Marcela Barrios Ospina Carlos Andrés Zabala Bello Esther Natalia Muñoz Roa Hernán Mauricio Rivera Escobar |
| author_sort | José Daniel Escobar Moreno |
| collection | DOAJ |
| description | Reactive oxygen species (ROS) are intermediates in oxidation–reduction reactions with the capacity to modify biomolecules and temporarily or permanently alter cell behaviour through signalling pathways under physiological and pathophysiological conditions where there is an imbalance between oxidative factors and the antioxidant response of the organism, a phenomenon known as oxidative stress. Evidence suggests that the differential modulation of ROS-mediated oxidative stress occurs in the pathogenesis and progression of melanoma, and that this imbalance in redox homeostasis appears to be functionally linked to microRNA (miRNA o miRs)-mediated non-mutational epigenetic reprogramming involving genes and transcription factors. The relationship between ROS-mediated stress control, tumour microenvironment, and miRNA expression in melanoma is not fully understood. The aim of this review is to analyse the involvement of miRNAs in the modulation of the signalling pathways involved in ROS-mediated oxidative stress in melanoma. It is hoped that these considerations will contribute to the understanding of the mechanisms associated with a potential epigenetic network regulation, where the modulation of oxidative stress is consolidated as a common factor in melanoma, and therefore, a potential footprint poorly documented. |
| format | Article |
| id | doaj-art-9985a7fe23e24ac8bac6949088cb39a3 |
| institution | OA Journals |
| issn | 2076-3921 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-9985a7fe23e24ac8bac6949088cb39a32025-08-20T01:53:42ZengMDPI AGAntioxidants2076-39212024-10-011311132610.3390/antiox13111326miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in MelanomaJosé Daniel Escobar Moreno0José Luis Fajardo Castiblanco1Laura Camila Riaño Rodriguez2Paula Marcela Barrios Ospina3Carlos Andrés Zabala Bello4Esther Natalia Muñoz Roa5Hernán Mauricio Rivera Escobar6Semillero de Investigación de Medicina (SIMED), Basic and Translational Research Group (GIBAT), Faculty of Medicine, Universidad El Bosque, Bogotá 110121, ColombiaSemillero de Investigación de Medicina (SIMED), Basic and Translational Research Group (GIBAT), Faculty of Medicine, Universidad El Bosque, Bogotá 110121, ColombiaSemillero de Investigación de Medicina (SIMED), Basic and Translational Research Group (GIBAT), Faculty of Medicine, Universidad El Bosque, Bogotá 110121, ColombiaSemillero de Investigación de Medicina (SIMED), Basic and Translational Research Group (GIBAT), Faculty of Medicine, Universidad El Bosque, Bogotá 110121, ColombiaLaboratory of Animal Cytogenetics, Faculty of Veterinary Medicine and Animal Science, Universidad Nacional de Colombia, Bogotá 111321, ColombiaPhD Program in Biological Sciences, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, ColombiaSemillero de Investigación de Medicina (SIMED), Basic and Translational Research Group (GIBAT), Faculty of Medicine, Universidad El Bosque, Bogotá 110121, ColombiaReactive oxygen species (ROS) are intermediates in oxidation–reduction reactions with the capacity to modify biomolecules and temporarily or permanently alter cell behaviour through signalling pathways under physiological and pathophysiological conditions where there is an imbalance between oxidative factors and the antioxidant response of the organism, a phenomenon known as oxidative stress. Evidence suggests that the differential modulation of ROS-mediated oxidative stress occurs in the pathogenesis and progression of melanoma, and that this imbalance in redox homeostasis appears to be functionally linked to microRNA (miRNA o miRs)-mediated non-mutational epigenetic reprogramming involving genes and transcription factors. The relationship between ROS-mediated stress control, tumour microenvironment, and miRNA expression in melanoma is not fully understood. The aim of this review is to analyse the involvement of miRNAs in the modulation of the signalling pathways involved in ROS-mediated oxidative stress in melanoma. It is hoped that these considerations will contribute to the understanding of the mechanisms associated with a potential epigenetic network regulation, where the modulation of oxidative stress is consolidated as a common factor in melanoma, and therefore, a potential footprint poorly documented.https://www.mdpi.com/2076-3921/13/11/1326melanomaROSmiRNAsredox homeostasisoxidative stress |
| spellingShingle | José Daniel Escobar Moreno José Luis Fajardo Castiblanco Laura Camila Riaño Rodriguez Paula Marcela Barrios Ospina Carlos Andrés Zabala Bello Esther Natalia Muñoz Roa Hernán Mauricio Rivera Escobar miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma Antioxidants melanoma ROS miRNAs redox homeostasis oxidative stress |
| title | miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma |
| title_full | miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma |
| title_fullStr | miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma |
| title_full_unstemmed | miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma |
| title_short | miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma |
| title_sort | mirnas involvement in modulating signalling pathways involved in ros mediated oxidative stress in melanoma |
| topic | melanoma ROS miRNAs redox homeostasis oxidative stress |
| url | https://www.mdpi.com/2076-3921/13/11/1326 |
| work_keys_str_mv | AT josedanielescobarmoreno mirnasinvolvementinmodulatingsignallingpathwaysinvolvedinrosmediatedoxidativestressinmelanoma AT joseluisfajardocastiblanco mirnasinvolvementinmodulatingsignallingpathwaysinvolvedinrosmediatedoxidativestressinmelanoma AT lauracamilarianorodriguez mirnasinvolvementinmodulatingsignallingpathwaysinvolvedinrosmediatedoxidativestressinmelanoma AT paulamarcelabarriosospina mirnasinvolvementinmodulatingsignallingpathwaysinvolvedinrosmediatedoxidativestressinmelanoma AT carlosandreszabalabello mirnasinvolvementinmodulatingsignallingpathwaysinvolvedinrosmediatedoxidativestressinmelanoma AT esthernataliamunozroa mirnasinvolvementinmodulatingsignallingpathwaysinvolvedinrosmediatedoxidativestressinmelanoma AT hernanmauricioriveraescobar mirnasinvolvementinmodulatingsignallingpathwaysinvolvedinrosmediatedoxidativestressinmelanoma |