Comparative Activity of Lipoglycopeptide Antibiotics Against Gram-Positive Bacteria
Lipoglycopeptide antibiotics are semi-synthetic derivatives of glycopeptides and are characterized by a pronounced bactericidal activity against gram-positive pathogens. The aim of the study was comparative assessment of the sensitivity of gram-positive clinical isolates to lipoglycopeptide antibiot...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Publishing House OKI"
2022-12-01
|
| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/964 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849403861260828672 |
|---|---|
| author | V. V. Gostev O. S. Sulian O. S. Kalinogorskaya L. N. Popenko A. N. Kruglov S. A. Gordeeva E. V. Nesterova D. P. Gladin N. N. Trophimova P. S. Chulkova I. V. Ageevets V. A. Ageevets T. V. Chernenkaya |
| author_facet | V. V. Gostev O. S. Sulian O. S. Kalinogorskaya L. N. Popenko A. N. Kruglov S. A. Gordeeva E. V. Nesterova D. P. Gladin N. N. Trophimova P. S. Chulkova I. V. Ageevets V. A. Ageevets T. V. Chernenkaya |
| author_sort | V. V. Gostev |
| collection | DOAJ |
| description | Lipoglycopeptide antibiotics are semi-synthetic derivatives of glycopeptides and are characterized by a pronounced bactericidal activity against gram-positive pathogens. The aim of the study was comparative assessment of the sensitivity of gram-positive clinical isolates to lipoglycopeptide antibiotics (telavancin, dalbavancin, oritavancin). The following isolates were included in the work: methicillin-resistant Staphylococcus aureus (MRSA, n=780), methicillin-resistant coagulase-negative Staphylococcus spp. (MRCoNS, n=163), and vancomycin-resistant Enterococcus faecium (VREf, n=93). Serial dilutions were used to assess sensitivity with the addition of 0.002% polysorbate 80 to the medium. Lipoglycopeptides showed more pronounced antibacterial activity against MRSA compared to vancomycin, teicoplanin, and daptomycin, and had a MIC₅₀/MIC₉₀ (µg/ml): for telavancin — 0.06 /0.125, for dalbavancin — 0.016/0.06, and for oritavancin — 0.06/0.125. A trend towards an increase in the MIC of lipoglycopeptides and daptomycin was established in MRSA with the MIC of 2 µg/ml for vancomycin, the proportion of which was 13%. For MRCoNS, MIC₅₀ and MIC₉₀ of lipoglycopeptides did not exceed 0.06 µg/ml and 0.125 µg/ml, respectively. Oritavancin showed strong activity against VREf at MIC range of 0.03 µg/ml to 0.5 µg/ml, and at MIC₉₀ of 0.25 µg/ml. Thus, lipoglycopeptide antibiotics are a plausible alternative to vancomycin and daptomycin; they are characterized by pronounced activity and can be used to treat severe forms of staphylococcal infections. |
| format | Article |
| id | doaj-art-99846c741b494c3da9f489092cfa00d6 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2022-12-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-99846c741b494c3da9f489092cfa00d62025-08-20T03:37:09ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902022-12-01679-10182410.37489/0235-2990-2022-67-9-10-18-24867Comparative Activity of Lipoglycopeptide Antibiotics Against Gram-Positive BacteriaV. V. Gostev0O. S. Sulian1O. S. Kalinogorskaya2L. N. Popenko3A. N. Kruglov4S. A. Gordeeva5E. V. Nesterova6D. P. Gladin7N. N. Trophimova8P. S. Chulkova9I. V. Ageevets10V. A. Ageevets11T. V. Chernenkaya12Pediatric Research and Clinical Center for Infectious Diseases; North-Western State Medical University Named after I. I. MechnikovPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesSt. Petersburg I. I. Dzhanelidze Research Institute of Emergency MedicineMoscow Multidisciplinary Clinical Center «Kommunarka»Clinical Infectious Diseases Hospital named after S.P. BotkinCity Skin and Venereal Diseases DispensarySt. Petersburg State Pediatric Medical University of the Ministry of Health of the Russian FederationCity Skin and Venereal Diseases DispensaryPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesN.V. Sklifosovsky Research Institute for Emergency MedicineLipoglycopeptide antibiotics are semi-synthetic derivatives of glycopeptides and are characterized by a pronounced bactericidal activity against gram-positive pathogens. The aim of the study was comparative assessment of the sensitivity of gram-positive clinical isolates to lipoglycopeptide antibiotics (telavancin, dalbavancin, oritavancin). The following isolates were included in the work: methicillin-resistant Staphylococcus aureus (MRSA, n=780), methicillin-resistant coagulase-negative Staphylococcus spp. (MRCoNS, n=163), and vancomycin-resistant Enterococcus faecium (VREf, n=93). Serial dilutions were used to assess sensitivity with the addition of 0.002% polysorbate 80 to the medium. Lipoglycopeptides showed more pronounced antibacterial activity against MRSA compared to vancomycin, teicoplanin, and daptomycin, and had a MIC₅₀/MIC₉₀ (µg/ml): for telavancin — 0.06 /0.125, for dalbavancin — 0.016/0.06, and for oritavancin — 0.06/0.125. A trend towards an increase in the MIC of lipoglycopeptides and daptomycin was established in MRSA with the MIC of 2 µg/ml for vancomycin, the proportion of which was 13%. For MRCoNS, MIC₅₀ and MIC₉₀ of lipoglycopeptides did not exceed 0.06 µg/ml and 0.125 µg/ml, respectively. Oritavancin showed strong activity against VREf at MIC range of 0.03 µg/ml to 0.5 µg/ml, and at MIC₉₀ of 0.25 µg/ml. Thus, lipoglycopeptide antibiotics are a plausible alternative to vancomycin and daptomycin; they are characterized by pronounced activity and can be used to treat severe forms of staphylococcal infections.https://www.antibiotics-chemotherapy.ru/jour/article/view/964staphylococcus aureusmrsastaphylococcienterococcisensitivityvancomycintelavancinoritavancindalbavancinteicoplanindaptomycin |
| spellingShingle | V. V. Gostev O. S. Sulian O. S. Kalinogorskaya L. N. Popenko A. N. Kruglov S. A. Gordeeva E. V. Nesterova D. P. Gladin N. N. Trophimova P. S. Chulkova I. V. Ageevets V. A. Ageevets T. V. Chernenkaya Comparative Activity of Lipoglycopeptide Antibiotics Against Gram-Positive Bacteria Антибиотики и Химиотерапия staphylococcus aureus mrsa staphylococci enterococci sensitivity vancomycin telavancin oritavancin dalbavancin teicoplanin daptomycin |
| title | Comparative Activity of Lipoglycopeptide Antibiotics Against Gram-Positive Bacteria |
| title_full | Comparative Activity of Lipoglycopeptide Antibiotics Against Gram-Positive Bacteria |
| title_fullStr | Comparative Activity of Lipoglycopeptide Antibiotics Against Gram-Positive Bacteria |
| title_full_unstemmed | Comparative Activity of Lipoglycopeptide Antibiotics Against Gram-Positive Bacteria |
| title_short | Comparative Activity of Lipoglycopeptide Antibiotics Against Gram-Positive Bacteria |
| title_sort | comparative activity of lipoglycopeptide antibiotics against gram positive bacteria |
| topic | staphylococcus aureus mrsa staphylococci enterococci sensitivity vancomycin telavancin oritavancin dalbavancin teicoplanin daptomycin |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/964 |
| work_keys_str_mv | AT vvgostev comparativeactivityoflipoglycopeptideantibioticsagainstgrampositivebacteria AT ossulian comparativeactivityoflipoglycopeptideantibioticsagainstgrampositivebacteria AT oskalinogorskaya comparativeactivityoflipoglycopeptideantibioticsagainstgrampositivebacteria AT lnpopenko comparativeactivityoflipoglycopeptideantibioticsagainstgrampositivebacteria AT ankruglov comparativeactivityoflipoglycopeptideantibioticsagainstgrampositivebacteria AT sagordeeva comparativeactivityoflipoglycopeptideantibioticsagainstgrampositivebacteria AT evnesterova comparativeactivityoflipoglycopeptideantibioticsagainstgrampositivebacteria AT dpgladin comparativeactivityoflipoglycopeptideantibioticsagainstgrampositivebacteria AT nntrophimova comparativeactivityoflipoglycopeptideantibioticsagainstgrampositivebacteria AT pschulkova comparativeactivityoflipoglycopeptideantibioticsagainstgrampositivebacteria AT ivageevets comparativeactivityoflipoglycopeptideantibioticsagainstgrampositivebacteria AT vaageevets comparativeactivityoflipoglycopeptideantibioticsagainstgrampositivebacteria AT tvchernenkaya comparativeactivityoflipoglycopeptideantibioticsagainstgrampositivebacteria |