Comparative Activity of Lipoglycopeptide Antibiotics Against Gram-Positive Bacteria

Comparative Activity of Lipoglycopeptide Antibiotics Against Gram-Positive Bacteria

Lipoglycopeptide antibiotics are semi-synthetic derivatives of glycopeptides and are characterized by a pronounced bactericidal activity against gram-positive pathogens. The aim of the study was comparative assessment of the sensitivity of gram-positive clinical isolates to lipoglycopeptide antibiot...

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Main Authors: V. V. Gostev, O. S. Sulian, O. S. Kalinogorskaya, L. N. Popenko, A. N. Kruglov, S. A. Gordeeva, E. V. Nesterova, D. P. Gladin, N. N. Trophimova, P. S. Chulkova, I. V. Ageevets, V. A. Ageevets, T. V. Chernenkaya
Format: Article
Language:Russian
Published: LLC "Publishing House OKI" 2022-12-01
Series:Антибиотики и Химиотерапия
Subjects:
staphylococcus aureus
mrsa
staphylococci
enterococci
sensitivity
vancomycin
telavancin
oritavancin
dalbavancin
teicoplanin
daptomycin
Online Access:https://www.antibiotics-chemotherapy.ru/jour/article/view/964
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Summary:Lipoglycopeptide antibiotics are semi-synthetic derivatives of glycopeptides and are characterized by a pronounced bactericidal activity against gram-positive pathogens. The aim of the study was comparative assessment of the sensitivity of gram-positive clinical isolates to lipoglycopeptide antibiotics (telavancin, dalbavancin, oritavancin). The following isolates were included in the work: methicillin-resistant Staphylococcus aureus (MRSA, n=780), methicillin-resistant coagulase-negative Staphylococcus spp. (MRCoNS, n=163), and vancomycin-resistant Enterococcus faecium (VREf, n=93). Serial dilutions were used to assess sensitivity with the addition of 0.002% polysorbate 80 to the medium. Lipoglycopeptides showed more pronounced antibacterial activity against MRSA compared to vancomycin, teicoplanin, and daptomycin, and had a MIC₅₀/MIC₉₀ (µg/ml): for telavancin — 0.06 /0.125, for dalbavancin — 0.016/0.06, and for oritavancin — 0.06/0.125. A trend towards an increase in the MIC of lipoglycopeptides and daptomycin was established in MRSA with the MIC of 2 µg/ml for vancomycin, the proportion of which was 13%. For MRCoNS, MIC₅₀ and MIC₉₀ of lipoglycopeptides did not exceed 0.06 µg/ml and 0.125 µg/ml, respectively. Oritavancin showed strong activity against VREf at MIC range of 0.03 µg/ml to 0.5 µg/ml, and at MIC₉₀ of 0.25 µg/ml. Thus, lipoglycopeptide antibiotics are a plausible alternative to vancomycin and daptomycin; they are characterized by pronounced activity and can be used to treat severe forms of staphylococcal infections.
ISSN:0235-2990

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