Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice

Abstract Aging involves the accumulation of various forms of molecular and cellular damage over time. Key features of aging, such as mitochondrial dysfunction, dysbiosis, and oxidative stress, are closely linked and largely driven by inflammation. This study examines the role of succinate, a key met...

Full description

Saved in:
Bibliographic Details
Main Authors: Fangxi Xu, Yuqi Guo, Scott C. Thomas, Anish Saxena, Samantha Hwang, Mridula Vardhan, Xin Li
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:International Journal of Oral Science
Online Access:https://doi.org/10.1038/s41368-025-00376-6
Tags: Add Tag
No Tags, Be the first to tag this record!