Secondary vs. primary pituitary xanthogranulomas: which yellow is more mellow?
Pituitary xanthogranulomatomas (XG) are a rare pathological entity caused by accumulation of lipid laden macrophages and reactive granuloma formation usually triggered by cystic fluid leakage or hemorrhage. Our aim was to compare clinical characteristics and presenting features of patients with seco...
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The Japan Endocrine Society
2024-03-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/3/71_EJ23-0398/_html/-char/en |
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| author | Dragana Miljic Sandra Pekic Mirjana Doknic Marko Stojanovic Sasa Ilic Marina Nikolic Djurovic Zvezdana Jemuovic Toplica Milojevic Mihailo Milicevic Marija Jovanovic Milica Medic Stojanoska Bojana Carić Nevena Radic Sanja Medenica Emilija Manojlovic Gacic Milan Petakov |
| author_facet | Dragana Miljic Sandra Pekic Mirjana Doknic Marko Stojanovic Sasa Ilic Marina Nikolic Djurovic Zvezdana Jemuovic Toplica Milojevic Mihailo Milicevic Marija Jovanovic Milica Medic Stojanoska Bojana Carić Nevena Radic Sanja Medenica Emilija Manojlovic Gacic Milan Petakov |
| author_sort | Dragana Miljic |
| collection | DOAJ |
| description | Pituitary xanthogranulomatomas (XG) are a rare pathological entity caused by accumulation of lipid laden macrophages and reactive granuloma formation usually triggered by cystic fluid leakage or hemorrhage. Our aim was to compare clinical characteristics and presenting features of patients with secondary etiology of XG and those with no identifiable founding lesion (primary -“pure” XG) in order to gain new insights into this rare pituitary pathology. In a retrospective review of 714 patients operated for sellar masses, at tertiary center, we identified 16 (2.24%) with histologically confirmed diagnosis of pituitary XG over the period of 7 years (2015–2021). Patients were further analyzed according to XG etiology: “pure”- XG (n = 8) with no identifiable founding lesion were compared to those with histological elements of pituitary tumor or cyst – secondary XG (n = 8). We identified 16 patients (11 male), mean age 44.8 ± 22.3 years, diagnosed with pituitary XG. Secondary forms were associated with Ratke’s cleft cyst (RCC, n = 2) and pituitary adenoma (PA, n = 6). The most common presenting features in both groups were hypopituitarism (75%), headache (68.5%) and visual disturbances (37.5%). Predominance of male sex was noted (males 68.75%, females 31.25%), especially in patients with primary forms. Patients with primary pituitary XG were all males (p = 0.0256) and more frequently affected by panhypopituitarism (87.5% vs. 25%, p = 0.0406) compared to patients with secondary causes. Hyperprolactinemia was noted in pituitary tumor group with secondary etiology only (p = 0.0769). Majority of lesions were solid on magnetic resonance imaging - MRI (81.25%). Distinct clinical phenotype was observed dependent on the etiology of XG. |
| format | Article |
| id | doaj-art-997e5d41cc9e4904bf16ba6c3560d120 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-997e5d41cc9e4904bf16ba6c3560d1202025-01-22T06:35:05ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-03-0171328529310.1507/endocrj.EJ23-0398endocrjSecondary vs. primary pituitary xanthogranulomas: which yellow is more mellow?Dragana Miljic0Sandra Pekic1Mirjana Doknic2Marko Stojanovic3Sasa Ilic4Marina Nikolic Djurovic5Zvezdana Jemuovic6Toplica Milojevic7Mihailo Milicevic8Marija Jovanovic9Milica Medic Stojanoska10Bojana Carić11Nevena Radic12Sanja Medenica13Emilija Manojlovic Gacic14Milan Petakov15Faculty of Medicine, University of Belgrade, Belgrade 11000, SerbiaFaculty of Medicine, University of Belgrade, Belgrade 11000, SerbiaFaculty of Medicine, University of Belgrade, Belgrade 11000, SerbiaFaculty of Medicine, University of Belgrade, Belgrade 11000, SerbiaClinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade 11000, SerbiaFaculty of Medicine, University of Belgrade, Belgrade 11000, SerbiaClinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade 11000, SerbiaClinic for Neurosurgery, University Clinical Center of Serbia, Belgrade 11000, SerbiaFaculty of Medicine, University of Belgrade, Belgrade 11000, SerbiaFaculty of Medicine, University of Belgrade, Belgrade 11000, SerbiaUniversity of Novi Sad, Faculty of Medicine, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Novi Sad 21000, SerbiaFaculty of Medicine, University of Banja Luka, University Clinical Center of Republic of Srpska, Banja Luka 78101, Bosnia and HerzegovinaClinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade 11000, SerbiaSchool of Medicine, University of Montenegro, Podgorica, Montenegro, Department of Endocrinology, Internal Medicine Clinic, Clinical Center of Montenegro, Podgorica 81110, MontenegroInstitute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade 11000, SerbiaFaculty of Medicine, University of Belgrade, Belgrade 11000, SerbiaPituitary xanthogranulomatomas (XG) are a rare pathological entity caused by accumulation of lipid laden macrophages and reactive granuloma formation usually triggered by cystic fluid leakage or hemorrhage. Our aim was to compare clinical characteristics and presenting features of patients with secondary etiology of XG and those with no identifiable founding lesion (primary -“pure” XG) in order to gain new insights into this rare pituitary pathology. In a retrospective review of 714 patients operated for sellar masses, at tertiary center, we identified 16 (2.24%) with histologically confirmed diagnosis of pituitary XG over the period of 7 years (2015–2021). Patients were further analyzed according to XG etiology: “pure”- XG (n = 8) with no identifiable founding lesion were compared to those with histological elements of pituitary tumor or cyst – secondary XG (n = 8). We identified 16 patients (11 male), mean age 44.8 ± 22.3 years, diagnosed with pituitary XG. Secondary forms were associated with Ratke’s cleft cyst (RCC, n = 2) and pituitary adenoma (PA, n = 6). The most common presenting features in both groups were hypopituitarism (75%), headache (68.5%) and visual disturbances (37.5%). Predominance of male sex was noted (males 68.75%, females 31.25%), especially in patients with primary forms. Patients with primary pituitary XG were all males (p = 0.0256) and more frequently affected by panhypopituitarism (87.5% vs. 25%, p = 0.0406) compared to patients with secondary causes. Hyperprolactinemia was noted in pituitary tumor group with secondary etiology only (p = 0.0769). Majority of lesions were solid on magnetic resonance imaging - MRI (81.25%). Distinct clinical phenotype was observed dependent on the etiology of XG.https://www.jstage.jst.go.jp/article/endocrj/71/3/71_EJ23-0398/_html/-char/enxanthogranulomapituitarypituitary neuroendocrine tumorrathke’s cleft cyst |
| spellingShingle | Dragana Miljic Sandra Pekic Mirjana Doknic Marko Stojanovic Sasa Ilic Marina Nikolic Djurovic Zvezdana Jemuovic Toplica Milojevic Mihailo Milicevic Marija Jovanovic Milica Medic Stojanoska Bojana Carić Nevena Radic Sanja Medenica Emilija Manojlovic Gacic Milan Petakov Secondary vs. primary pituitary xanthogranulomas: which yellow is more mellow? Endocrine Journal xanthogranuloma pituitary pituitary neuroendocrine tumor rathke’s cleft cyst |
| title | Secondary vs. primary pituitary xanthogranulomas: which yellow is more mellow? |
| title_full | Secondary vs. primary pituitary xanthogranulomas: which yellow is more mellow? |
| title_fullStr | Secondary vs. primary pituitary xanthogranulomas: which yellow is more mellow? |
| title_full_unstemmed | Secondary vs. primary pituitary xanthogranulomas: which yellow is more mellow? |
| title_short | Secondary vs. primary pituitary xanthogranulomas: which yellow is more mellow? |
| title_sort | secondary vs primary pituitary xanthogranulomas which yellow is more mellow |
| topic | xanthogranuloma pituitary pituitary neuroendocrine tumor rathke’s cleft cyst |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/3/71_EJ23-0398/_html/-char/en |
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