Respiratory delivered vaccines: Current status and perspectives in rational formulation design
The respiratory tract is susceptible to various infections and can be affected by many serious diseases. Vaccination is one of the most promising ways that prevent infectious diseases and treatment of some diseases such as malignancy. Direct delivery of vaccines to the respiratory tract could mimic...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383524003435 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850251262215323648 |
|---|---|
| author | Lan Wu Wenwen Xu Huiyang Jiang Mingshi Yang Dongmei Cun |
| author_facet | Lan Wu Wenwen Xu Huiyang Jiang Mingshi Yang Dongmei Cun |
| author_sort | Lan Wu |
| collection | DOAJ |
| description | The respiratory tract is susceptible to various infections and can be affected by many serious diseases. Vaccination is one of the most promising ways that prevent infectious diseases and treatment of some diseases such as malignancy. Direct delivery of vaccines to the respiratory tract could mimic the natural process of infection and shorten the delivery path, therefore unique mucosal immunity at the first line might be induced and the efficiency of delivery can be high. Despite considerable attempts at the development of respiratory vaccines, the rational formulation design still warrants attention, i.e., how the formulation composition, particle properties, formulation type (liquid or solid), and devices would influence the immune outcome. This article reviews the recent advances in the formulation design and development of respiratory vaccines. The focus is on the state of the art of delivering antigenic compounds through the respiratory tract, overcoming the pulmonary bio-barriers, enhancing delivery efficiencies of respiratory vaccines as well as maintaining the stability of vaccines during storage and use. The choice of devices and the influence of deposition sites on vaccine efficiencies were also reviewed. |
| format | Article |
| id | doaj-art-997c243a09e946929d539ef3f3209ee4 |
| institution | OA Journals |
| issn | 2211-3835 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj-art-997c243a09e946929d539ef3f3209ee42025-08-20T01:57:56ZengElsevierActa Pharmaceutica Sinica B2211-38352024-12-0114125132516010.1016/j.apsb.2024.08.026Respiratory delivered vaccines: Current status and perspectives in rational formulation designLan Wu0Wenwen Xu1Huiyang Jiang2Mingshi Yang3Dongmei Cun4Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang 110016, ChinaWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang 110016, ChinaWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang 110016, ChinaWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang 110016, China; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark; Corresponding authors.Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang 110016, China; School of Food and Drug, Shenzhen Polytechnic University, China, Shenzhen 518055, China; Corresponding authors.The respiratory tract is susceptible to various infections and can be affected by many serious diseases. Vaccination is one of the most promising ways that prevent infectious diseases and treatment of some diseases such as malignancy. Direct delivery of vaccines to the respiratory tract could mimic the natural process of infection and shorten the delivery path, therefore unique mucosal immunity at the first line might be induced and the efficiency of delivery can be high. Despite considerable attempts at the development of respiratory vaccines, the rational formulation design still warrants attention, i.e., how the formulation composition, particle properties, formulation type (liquid or solid), and devices would influence the immune outcome. This article reviews the recent advances in the formulation design and development of respiratory vaccines. The focus is on the state of the art of delivering antigenic compounds through the respiratory tract, overcoming the pulmonary bio-barriers, enhancing delivery efficiencies of respiratory vaccines as well as maintaining the stability of vaccines during storage and use. The choice of devices and the influence of deposition sites on vaccine efficiencies were also reviewed.http://www.sciencedirect.com/science/article/pii/S2211383524003435Respiratory vaccinesRespiratory drug delivery strategiesMucosal immunityBiomacromolecule delivery systemsInhaled formulationParticle engineering |
| spellingShingle | Lan Wu Wenwen Xu Huiyang Jiang Mingshi Yang Dongmei Cun Respiratory delivered vaccines: Current status and perspectives in rational formulation design Acta Pharmaceutica Sinica B Respiratory vaccines Respiratory drug delivery strategies Mucosal immunity Biomacromolecule delivery systems Inhaled formulation Particle engineering |
| title | Respiratory delivered vaccines: Current status and perspectives in rational formulation design |
| title_full | Respiratory delivered vaccines: Current status and perspectives in rational formulation design |
| title_fullStr | Respiratory delivered vaccines: Current status and perspectives in rational formulation design |
| title_full_unstemmed | Respiratory delivered vaccines: Current status and perspectives in rational formulation design |
| title_short | Respiratory delivered vaccines: Current status and perspectives in rational formulation design |
| title_sort | respiratory delivered vaccines current status and perspectives in rational formulation design |
| topic | Respiratory vaccines Respiratory drug delivery strategies Mucosal immunity Biomacromolecule delivery systems Inhaled formulation Particle engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2211383524003435 |
| work_keys_str_mv | AT lanwu respiratorydeliveredvaccinescurrentstatusandperspectivesinrationalformulationdesign AT wenwenxu respiratorydeliveredvaccinescurrentstatusandperspectivesinrationalformulationdesign AT huiyangjiang respiratorydeliveredvaccinescurrentstatusandperspectivesinrationalformulationdesign AT mingshiyang respiratorydeliveredvaccinescurrentstatusandperspectivesinrationalformulationdesign AT dongmeicun respiratorydeliveredvaccinescurrentstatusandperspectivesinrationalformulationdesign |