The potential role of probiotics and their bioactive compounds in the management of pulmonary tuberculosis
The significance of gut microbiota in human health is well recognized, yet its effects on pulmonary infectious diseases like tuberculosis (TB) are not thoroughly comprehended. While anti-TB drugs and preventive strategies are indispensable, the incorporation of adjunct therapies, including probiotic...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Journal of Infection and Public Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034125001893 |
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| author | Hamed Memariani Mojtaba Memariani Seyed Ebrahim Eskandari Abdolmajid Ghasemian Ali Nour Neamatollahi |
| author_facet | Hamed Memariani Mojtaba Memariani Seyed Ebrahim Eskandari Abdolmajid Ghasemian Ali Nour Neamatollahi |
| author_sort | Hamed Memariani |
| collection | DOAJ |
| description | The significance of gut microbiota in human health is well recognized, yet its effects on pulmonary infectious diseases like tuberculosis (TB) are not thoroughly comprehended. While anti-TB drugs and preventive strategies are indispensable, the incorporation of adjunct therapies, including probiotics and their bioactive compounds, could provide potential biotherapeutic benefits. This review strives to collate the recent experimental and clinical investigations into the manipulation of the gut microbiome through probiotics, exploring their potential to sustain eubiosis, enhance recovery from TB, and mitigate the adverse effects of anti-TB therapies. The multi-pronged mechanisms by which probiotics act against M. tuberculosis include their immunomodulatory properties, the promotion of autophagy, direct inhibition of the pathogen growth via bacteriocin production, the reduction of adverse effects from anti-TB drugs, and a diminished risk of comorbidities. Future research should prioritize high-quality randomized controlled trials that integrate omics with personalized microbiome-based therapeutic approaches to combat TB. |
| format | Article |
| id | doaj-art-997bbcd8faa446afbf2ab33f6595e495 |
| institution | DOAJ |
| issn | 1876-0341 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj-art-997bbcd8faa446afbf2ab33f6595e4952025-08-20T03:22:48ZengElsevierJournal of Infection and Public Health1876-03412025-09-0118910284010.1016/j.jiph.2025.102840The potential role of probiotics and their bioactive compounds in the management of pulmonary tuberculosisHamed Memariani0Mojtaba Memariani1Seyed Ebrahim Eskandari2Abdolmajid Ghasemian3Ali Nour Neamatollahi4Biotechnology Research Center, Pasteur Institute of Iran, Tehran, IranDepartment of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran; Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran; Corresponding author at: Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, IranNoncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, IranDepartment of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran; Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, IranThe significance of gut microbiota in human health is well recognized, yet its effects on pulmonary infectious diseases like tuberculosis (TB) are not thoroughly comprehended. While anti-TB drugs and preventive strategies are indispensable, the incorporation of adjunct therapies, including probiotics and their bioactive compounds, could provide potential biotherapeutic benefits. This review strives to collate the recent experimental and clinical investigations into the manipulation of the gut microbiome through probiotics, exploring their potential to sustain eubiosis, enhance recovery from TB, and mitigate the adverse effects of anti-TB therapies. The multi-pronged mechanisms by which probiotics act against M. tuberculosis include their immunomodulatory properties, the promotion of autophagy, direct inhibition of the pathogen growth via bacteriocin production, the reduction of adverse effects from anti-TB drugs, and a diminished risk of comorbidities. Future research should prioritize high-quality randomized controlled trials that integrate omics with personalized microbiome-based therapeutic approaches to combat TB.http://www.sciencedirect.com/science/article/pii/S1876034125001893ProbioticsMycobacterium tuberculosisgut microbiomeimmune response |
| spellingShingle | Hamed Memariani Mojtaba Memariani Seyed Ebrahim Eskandari Abdolmajid Ghasemian Ali Nour Neamatollahi The potential role of probiotics and their bioactive compounds in the management of pulmonary tuberculosis Journal of Infection and Public Health Probiotics Mycobacterium tuberculosis gut microbiome immune response |
| title | The potential role of probiotics and their bioactive compounds in the management of pulmonary tuberculosis |
| title_full | The potential role of probiotics and their bioactive compounds in the management of pulmonary tuberculosis |
| title_fullStr | The potential role of probiotics and their bioactive compounds in the management of pulmonary tuberculosis |
| title_full_unstemmed | The potential role of probiotics and their bioactive compounds in the management of pulmonary tuberculosis |
| title_short | The potential role of probiotics and their bioactive compounds in the management of pulmonary tuberculosis |
| title_sort | potential role of probiotics and their bioactive compounds in the management of pulmonary tuberculosis |
| topic | Probiotics Mycobacterium tuberculosis gut microbiome immune response |
| url | http://www.sciencedirect.com/science/article/pii/S1876034125001893 |
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