Relationship between serum lipid level and colorectal cancer: a systemic review and meta-analysis
Objective Investigative studies report contradictory results of the relationship between serum lipid levels and the risk of colorectal cancer (CRC). We conducted a meta-analysis of prospective published studies to clarify the relationship between serum lipid and CRC risk.Design Systematic review and...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e052373.full |
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| author | Shuai Lu Zhenpeng Yang Huazhen Tang Xibo Sun Benqiang Rao |
| author_facet | Shuai Lu Zhenpeng Yang Huazhen Tang Xibo Sun Benqiang Rao |
| author_sort | Shuai Lu |
| collection | DOAJ |
| description | Objective Investigative studies report contradictory results of the relationship between serum lipid levels and the risk of colorectal cancer (CRC). We conducted a meta-analysis of prospective published studies to clarify the relationship between serum lipid and CRC risk.Design Systematic review and meta-analysis.Data Sources PubMed and Embase from inception until December 2020.Eligibility criteria We considered prospective cohort and case–control studies that evaluated differences in serum lipid levels with the risk of developing CRC.Data extraction and synthesis Two independent reviewers screened and included the studies using standardised electronic data extraction forms. The relative risks of the studies were combined with random-effect and fixed-effect models and were analysed for heterogeneity, publication bias and sensitivity.Results Twenty-four prospective studies, including 4 224 317 individuals with 29 499 CRC cases, were included in the meta-analysis. The total pooled risk ratio (RR) for high vs low concentrations of triglyceride (TG) concentrations was reported at 1.21 (95% CI 1.09 to 1.34; I2=46.8%), total cholesterol (TC) was at 1.15 (95% CI 1.08 to 1.22; I2=36.8%), high-density lipoprotein cholesterol (HDL-C) was 0.86 (95% CI 0.77 to 0.97; I2=28.8%) and low-density lipoprotein cholesterol (LDL-C) was observed at 1.03 (95% CI 0.75 to 1.41; I2=69.4%).Conclusions This meta-analysis shows that high levels of serum TG and TC are positively correlated with the incidence rate of CRC, while high levels of serum HDL-C are negatively correlated with CRC incidence rate. Furthermore, no association was found between LDL-C and the risk of developing CRC. Nevertheless, the heterogeneity brought about by comparative methods, demographic differences and pathological differences between the research subjects limits the effectiveness of the overall pooled results. |
| format | Article |
| id | doaj-art-997715f500ac40f1971104d19ab8f5ae |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-997715f500ac40f1971104d19ab8f5ae2025-01-28T04:00:10ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-052373Relationship between serum lipid level and colorectal cancer: a systemic review and meta-analysisShuai Lu0Zhenpeng Yang1Huazhen Tang2Xibo Sun3Benqiang Rao4General Surgery, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, ChinaGeneral Surgery, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, ChinaGeneral Surgery, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, ChinaGeneral Surgery, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, ChinaGeneral Surgery, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, ChinaObjective Investigative studies report contradictory results of the relationship between serum lipid levels and the risk of colorectal cancer (CRC). We conducted a meta-analysis of prospective published studies to clarify the relationship between serum lipid and CRC risk.Design Systematic review and meta-analysis.Data Sources PubMed and Embase from inception until December 2020.Eligibility criteria We considered prospective cohort and case–control studies that evaluated differences in serum lipid levels with the risk of developing CRC.Data extraction and synthesis Two independent reviewers screened and included the studies using standardised electronic data extraction forms. The relative risks of the studies were combined with random-effect and fixed-effect models and were analysed for heterogeneity, publication bias and sensitivity.Results Twenty-four prospective studies, including 4 224 317 individuals with 29 499 CRC cases, were included in the meta-analysis. The total pooled risk ratio (RR) for high vs low concentrations of triglyceride (TG) concentrations was reported at 1.21 (95% CI 1.09 to 1.34; I2=46.8%), total cholesterol (TC) was at 1.15 (95% CI 1.08 to 1.22; I2=36.8%), high-density lipoprotein cholesterol (HDL-C) was 0.86 (95% CI 0.77 to 0.97; I2=28.8%) and low-density lipoprotein cholesterol (LDL-C) was observed at 1.03 (95% CI 0.75 to 1.41; I2=69.4%).Conclusions This meta-analysis shows that high levels of serum TG and TC are positively correlated with the incidence rate of CRC, while high levels of serum HDL-C are negatively correlated with CRC incidence rate. Furthermore, no association was found between LDL-C and the risk of developing CRC. Nevertheless, the heterogeneity brought about by comparative methods, demographic differences and pathological differences between the research subjects limits the effectiveness of the overall pooled results.https://bmjopen.bmj.com/content/12/6/e052373.full |
| spellingShingle | Shuai Lu Zhenpeng Yang Huazhen Tang Xibo Sun Benqiang Rao Relationship between serum lipid level and colorectal cancer: a systemic review and meta-analysis BMJ Open |
| title | Relationship between serum lipid level and colorectal cancer: a systemic review and meta-analysis |
| title_full | Relationship between serum lipid level and colorectal cancer: a systemic review and meta-analysis |
| title_fullStr | Relationship between serum lipid level and colorectal cancer: a systemic review and meta-analysis |
| title_full_unstemmed | Relationship between serum lipid level and colorectal cancer: a systemic review and meta-analysis |
| title_short | Relationship between serum lipid level and colorectal cancer: a systemic review and meta-analysis |
| title_sort | relationship between serum lipid level and colorectal cancer a systemic review and meta analysis |
| url | https://bmjopen.bmj.com/content/12/6/e052373.full |
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