Identification and modulation of a PI3K/AKT/mTOR pathway-targeting microRNA in order to increase colorectal cancer cells radiosensitivity in vitro

Identification and modulation of a PI3K/AKT/mTOR pathway-targeting microRNA in order to increase colorectal cancer cells radiosensitivity in vitro

Abstract Background The progression of colorectal cancer (CRC) occurs via the PI3K/AKT/mTOR signaling pathway. Recent evidence suggests that microRNAs (miRNAs) can modulate gene expression, potentially offering new treatment options. This study aims to identify a miRNA that enhances radiosensitivity...

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Bibliographic Details
Main Authors: Seyedeh Nasibeh Mousavikia, Maryam M. Matin, Mohammad Taghi Bahreyni Tossi, Seyed Hamid Aghaee-Bakhtiari, Hosein Azimian
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
Colorectal Cancer
Radioresistance
PI3K/AKT/mTOR pathway
MicroRNA
Hsa-miR-16-5p
Online Access:https://doi.org/10.1186/s12885-025-14501-5
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