Setting the Stage for Branched-Chain Amino Acids Use in Neurological Pathologies: Does a Single Oral Dose Provide Hours of Elevated Systemic Levels?
Background: Recent studies have demonstrated that branched-chain amino acids are neuroprotective and neurorestorative. Branched-chain amino acid supplements are now being recommended to be taken before contact sports to reduce concussions. While peaks and troughs in branched-chain amino acids have p...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Diseases |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-9721/13/3/76 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850089482895753216 |
|---|---|
| author | Ezek Mathew Nathan Jones McKinley Dews Dominique Neal Anders Cohen |
| author_facet | Ezek Mathew Nathan Jones McKinley Dews Dominique Neal Anders Cohen |
| author_sort | Ezek Mathew |
| collection | DOAJ |
| description | Background: Recent studies have demonstrated that branched-chain amino acids are neuroprotective and neurorestorative. Branched-chain amino acid supplements are now being recommended to be taken before contact sports to reduce concussions. While peaks and troughs in branched-chain amino acids have previously been reported in hospital settings, the metabolism of a single recommended dose of over-the-counter branched-chain amino acids has yet to be elucidated. Methods: We analyzed a patented branched-chain amino acid product to assess its metabolism in 10 healthy adults. Results: Over the defined time points, measured levels of branched-chain amino acids remained significantly elevated when compared to the physiological baseline. The elevations in measured plasma levels indicate that a single oral dose is a viable intake option for increasing levels of branched-chain amino acids. Conclusions: This information can be leveraged to better plan branched-chain amino acid-based treatment doses in order to treat pathologies such as brain injury. |
| format | Article |
| id | doaj-art-99730ca58598484f8a1d1fe4d0a502e0 |
| institution | DOAJ |
| issn | 2079-9721 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj-art-99730ca58598484f8a1d1fe4d0a502e02025-08-20T02:42:46ZengMDPI AGDiseases2079-97212025-03-011337610.3390/diseases13030076Setting the Stage for Branched-Chain Amino Acids Use in Neurological Pathologies: Does a Single Oral Dose Provide Hours of Elevated Systemic Levels?Ezek Mathew0Nathan Jones1McKinley Dews2Dominique Neal3Anders Cohen4Department of Microbiology and Immunology, The University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USADepartment of Microbiology and Immunology, The University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USADepartment of Microbiology and Immunology, The University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USADepartment of Microbiology and Immunology, The University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USADepartment of Neurological Surgery, The Brooklyn Hospital Center, 121 DeKalb Avenue, Brooklyn, NY 11201, USABackground: Recent studies have demonstrated that branched-chain amino acids are neuroprotective and neurorestorative. Branched-chain amino acid supplements are now being recommended to be taken before contact sports to reduce concussions. While peaks and troughs in branched-chain amino acids have previously been reported in hospital settings, the metabolism of a single recommended dose of over-the-counter branched-chain amino acids has yet to be elucidated. Methods: We analyzed a patented branched-chain amino acid product to assess its metabolism in 10 healthy adults. Results: Over the defined time points, measured levels of branched-chain amino acids remained significantly elevated when compared to the physiological baseline. The elevations in measured plasma levels indicate that a single oral dose is a viable intake option for increasing levels of branched-chain amino acids. Conclusions: This information can be leveraged to better plan branched-chain amino acid-based treatment doses in order to treat pathologies such as brain injury.https://www.mdpi.com/2079-9721/13/3/76branched-chain amino acidsBCAAconcussionbrain injurytraumatic brain injury |
| spellingShingle | Ezek Mathew Nathan Jones McKinley Dews Dominique Neal Anders Cohen Setting the Stage for Branched-Chain Amino Acids Use in Neurological Pathologies: Does a Single Oral Dose Provide Hours of Elevated Systemic Levels? Diseases branched-chain amino acids BCAA concussion brain injury traumatic brain injury |
| title | Setting the Stage for Branched-Chain Amino Acids Use in Neurological Pathologies: Does a Single Oral Dose Provide Hours of Elevated Systemic Levels? |
| title_full | Setting the Stage for Branched-Chain Amino Acids Use in Neurological Pathologies: Does a Single Oral Dose Provide Hours of Elevated Systemic Levels? |
| title_fullStr | Setting the Stage for Branched-Chain Amino Acids Use in Neurological Pathologies: Does a Single Oral Dose Provide Hours of Elevated Systemic Levels? |
| title_full_unstemmed | Setting the Stage for Branched-Chain Amino Acids Use in Neurological Pathologies: Does a Single Oral Dose Provide Hours of Elevated Systemic Levels? |
| title_short | Setting the Stage for Branched-Chain Amino Acids Use in Neurological Pathologies: Does a Single Oral Dose Provide Hours of Elevated Systemic Levels? |
| title_sort | setting the stage for branched chain amino acids use in neurological pathologies does a single oral dose provide hours of elevated systemic levels |
| topic | branched-chain amino acids BCAA concussion brain injury traumatic brain injury |
| url | https://www.mdpi.com/2079-9721/13/3/76 |
| work_keys_str_mv | AT ezekmathew settingthestageforbranchedchainaminoacidsuseinneurologicalpathologiesdoesasingleoraldoseprovidehoursofelevatedsystemiclevels AT nathanjones settingthestageforbranchedchainaminoacidsuseinneurologicalpathologiesdoesasingleoraldoseprovidehoursofelevatedsystemiclevels AT mckinleydews settingthestageforbranchedchainaminoacidsuseinneurologicalpathologiesdoesasingleoraldoseprovidehoursofelevatedsystemiclevels AT dominiqueneal settingthestageforbranchedchainaminoacidsuseinneurologicalpathologiesdoesasingleoraldoseprovidehoursofelevatedsystemiclevels AT anderscohen settingthestageforbranchedchainaminoacidsuseinneurologicalpathologiesdoesasingleoraldoseprovidehoursofelevatedsystemiclevels |