Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis
Background. The aim of this study was to determine the risk factors of MTX-associated nonalcoholic fatty liver disease (NAFLD) with transaminitis in a cohort of rheumatoid arthritis (RA) patients from Singapore. Methods. Patients who developed ultrasound proven NAFLD with transaminitis while on MTX...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/823763 |
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| author | Rajalingham Sakthiswary Grace Yin Lai Chan Ee Tzun Koh Khai Pang Leong Bernard Yu Hor Thong |
| author_facet | Rajalingham Sakthiswary Grace Yin Lai Chan Ee Tzun Koh Khai Pang Leong Bernard Yu Hor Thong |
| author_sort | Rajalingham Sakthiswary |
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| description | Background. The aim of this study was to determine the risk factors of MTX-associated nonalcoholic fatty liver disease (NAFLD) with transaminitis in a cohort of rheumatoid arthritis (RA) patients from Singapore. Methods. Patients who developed ultrasound proven NAFLD with transaminitis while on MTX therapy were identified. The demographic and clinical characteristics of the above patients (cases) were compiled and compared with age- and gender-matched controls who were RA patients on long standing MTX therapy without any episode of transaminitis. Results. Among the 978 patients who had received MTX, the prevalence of MTX-associated NAFLD was 4.7% (46 patients). Compared to the controls, the cases had significantly higher mean cumulative dose of MTX (4.03 ± 2.25 g versus 10.04 ± 9.94 g, P≤0.05), weekly dose of MTX (11.3 ± 4.8 mg versus 13.1 ± 4.4 mg weekly, P=0.033), and fasting blood glucose (P=0.029). Following multivariate regression analysis, only cumulative dose of MTX remained significant (P=0.015). Among the cases, the cumulative dose of MTX was found to have a significant positive correlation with the alanine transaminase (ALT) level (P<0.05, standardised beta coefficient 0.512). Conclusion. The cumulative dose of MTX was the only independent predictor of MTX-associated NAFLD with transaminitis. |
| format | Article |
| id | doaj-art-99722891231b4d6ba02d7805ffae8755 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | The Scientific World Journal |
| spelling | doaj-art-99722891231b4d6ba02d7805ffae87552025-02-03T01:20:57ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/823763823763Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid ArthritisRajalingham Sakthiswary0Grace Yin Lai Chan1Ee Tzun Koh2Khai Pang Leong3Bernard Yu Hor Thong4Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 308433, SingaporeDepartment of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 308433, SingaporeDepartment of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 308433, SingaporeDepartment of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 308433, SingaporeDepartment of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 308433, SingaporeBackground. The aim of this study was to determine the risk factors of MTX-associated nonalcoholic fatty liver disease (NAFLD) with transaminitis in a cohort of rheumatoid arthritis (RA) patients from Singapore. Methods. Patients who developed ultrasound proven NAFLD with transaminitis while on MTX therapy were identified. The demographic and clinical characteristics of the above patients (cases) were compiled and compared with age- and gender-matched controls who were RA patients on long standing MTX therapy without any episode of transaminitis. Results. Among the 978 patients who had received MTX, the prevalence of MTX-associated NAFLD was 4.7% (46 patients). Compared to the controls, the cases had significantly higher mean cumulative dose of MTX (4.03 ± 2.25 g versus 10.04 ± 9.94 g, P≤0.05), weekly dose of MTX (11.3 ± 4.8 mg versus 13.1 ± 4.4 mg weekly, P=0.033), and fasting blood glucose (P=0.029). Following multivariate regression analysis, only cumulative dose of MTX remained significant (P=0.015). Among the cases, the cumulative dose of MTX was found to have a significant positive correlation with the alanine transaminase (ALT) level (P<0.05, standardised beta coefficient 0.512). Conclusion. The cumulative dose of MTX was the only independent predictor of MTX-associated NAFLD with transaminitis.http://dx.doi.org/10.1155/2014/823763 |
| spellingShingle | Rajalingham Sakthiswary Grace Yin Lai Chan Ee Tzun Koh Khai Pang Leong Bernard Yu Hor Thong Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis The Scientific World Journal |
| title | Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis |
| title_full | Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis |
| title_fullStr | Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis |
| title_full_unstemmed | Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis |
| title_short | Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis |
| title_sort | methotrexate associated nonalcoholic fatty liver disease with transaminitis in rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2014/823763 |
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