A preserved transseptal puncture zone in a novel PFO occluder enables safe repeat left atrial interventions: preclinical validation in a porcine model

A preserved transseptal puncture zone in a novel PFO occluder enables safe repeat left atrial interventions: preclinical validation in a porcine model

BackgroundConventional nickel-titanium patent foramen ovale (PFO) occluders hinder transseptal puncture due to septal obstruction, limiting access for left-heart interventions. To address this, we developed a modified PFO occluder with a designated puncturable zone.MethodsAn artificial PFO model was...

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Bibliographic Details
Main Authors: Hao Chen, Yanlin Su, Ziqian He, Yiting Wei, Zihe Dang, Suyan Cao, Wenlin Lu, Shaoqing Cao, Chengjian Yang, Haibin Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
patent foramen ovale (PFO)
transseptal puncture
left atrial appendage closure (LAAC)
interventional cardiology
preclinical study
device innovation
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1587015/full
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