A preserved transseptal puncture zone in a novel PFO occluder enables safe repeat left atrial interventions: preclinical validation in a porcine model
BackgroundConventional nickel-titanium patent foramen ovale (PFO) occluders hinder transseptal puncture due to septal obstruction, limiting access for left-heart interventions. To address this, we developed a modified PFO occluder with a designated puncturable zone.MethodsAn artificial PFO model was...
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| Format: | Article |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1587015/full |
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| author | Hao Chen Yanlin Su Ziqian He Yiting Wei Zihe Dang Suyan Cao Wenlin Lu Shaoqing Cao Chengjian Yang Haibin Jiang |
| author_facet | Hao Chen Yanlin Su Ziqian He Yiting Wei Zihe Dang Suyan Cao Wenlin Lu Shaoqing Cao Chengjian Yang Haibin Jiang |
| author_sort | Hao Chen |
| collection | DOAJ |
| description | BackgroundConventional nickel-titanium patent foramen ovale (PFO) occluders hinder transseptal puncture due to septal obstruction, limiting access for left-heart interventions. To address this, we developed a modified PFO occluder with a designated puncturable zone.MethodsAn artificial PFO model was created in six pigs by puncturing and dilating the fossa ovalis. A novel PFO occluder preserving a central puncture area was implanted and validated intraoperatively via digital subtraction angiography (DSA) and transesophageal echocardiography (TEE). Transthoracic echocardiography and histology were performed 3 months post-implantation. Transseptal left atrial appendage closure (LAAC) was subsequently attempted through the occluder's puncturable zone.ResultsAll PFO closures were successful, with DSA/TEE confirming device stability. At 3 months, transseptal LAAC via the occluder's preserved area was achieved in all cases (6/6), validated by imaging. Histology revealed complete endothelialization of both occluders, intact nitinol framework, and precise puncture tracks within the designated zone without structural compromise.ConclusionThe novel PFO occluder with a dedicated puncture zone enables effective PFO closure while permitting safe transseptal access for subsequent left-heart interventions. This study demonstrates the occluder's feasibility, reliability, and clinical potential for aging populations requiring sequential cardiac procedures. |
| format | Article |
| id | doaj-art-9971bb714f4f4c62bf6793baef2bf17b |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-9971bb714f4f4c62bf6793baef2bf17b2025-08-20T02:35:33ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-06-011210.3389/fcvm.2025.15870151587015A preserved transseptal puncture zone in a novel PFO occluder enables safe repeat left atrial interventions: preclinical validation in a porcine modelHao ChenYanlin SuZiqian HeYiting WeiZihe DangSuyan CaoWenlin LuShaoqing CaoChengjian YangHaibin JiangBackgroundConventional nickel-titanium patent foramen ovale (PFO) occluders hinder transseptal puncture due to septal obstruction, limiting access for left-heart interventions. To address this, we developed a modified PFO occluder with a designated puncturable zone.MethodsAn artificial PFO model was created in six pigs by puncturing and dilating the fossa ovalis. A novel PFO occluder preserving a central puncture area was implanted and validated intraoperatively via digital subtraction angiography (DSA) and transesophageal echocardiography (TEE). Transthoracic echocardiography and histology were performed 3 months post-implantation. Transseptal left atrial appendage closure (LAAC) was subsequently attempted through the occluder's puncturable zone.ResultsAll PFO closures were successful, with DSA/TEE confirming device stability. At 3 months, transseptal LAAC via the occluder's preserved area was achieved in all cases (6/6), validated by imaging. Histology revealed complete endothelialization of both occluders, intact nitinol framework, and precise puncture tracks within the designated zone without structural compromise.ConclusionThe novel PFO occluder with a dedicated puncture zone enables effective PFO closure while permitting safe transseptal access for subsequent left-heart interventions. This study demonstrates the occluder's feasibility, reliability, and clinical potential for aging populations requiring sequential cardiac procedures.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1587015/fullpatent foramen ovale (PFO)transseptal punctureleft atrial appendage closure (LAAC)interventional cardiologypreclinical studydevice innovation |
| spellingShingle | Hao Chen Yanlin Su Ziqian He Yiting Wei Zihe Dang Suyan Cao Wenlin Lu Shaoqing Cao Chengjian Yang Haibin Jiang A preserved transseptal puncture zone in a novel PFO occluder enables safe repeat left atrial interventions: preclinical validation in a porcine model Frontiers in Cardiovascular Medicine patent foramen ovale (PFO) transseptal puncture left atrial appendage closure (LAAC) interventional cardiology preclinical study device innovation |
| title | A preserved transseptal puncture zone in a novel PFO occluder enables safe repeat left atrial interventions: preclinical validation in a porcine model |
| title_full | A preserved transseptal puncture zone in a novel PFO occluder enables safe repeat left atrial interventions: preclinical validation in a porcine model |
| title_fullStr | A preserved transseptal puncture zone in a novel PFO occluder enables safe repeat left atrial interventions: preclinical validation in a porcine model |
| title_full_unstemmed | A preserved transseptal puncture zone in a novel PFO occluder enables safe repeat left atrial interventions: preclinical validation in a porcine model |
| title_short | A preserved transseptal puncture zone in a novel PFO occluder enables safe repeat left atrial interventions: preclinical validation in a porcine model |
| title_sort | preserved transseptal puncture zone in a novel pfo occluder enables safe repeat left atrial interventions preclinical validation in a porcine model |
| topic | patent foramen ovale (PFO) transseptal puncture left atrial appendage closure (LAAC) interventional cardiology preclinical study device innovation |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1587015/full |
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