Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men
HIV-infected individuals are at risk for decreased bone mineral density (BMD). The known risk factors for bone loss do not fully explain the increased risk in this population. There is emerging evidence that leptin, a hormone secreted by adipocytes, plays an important role in bone metabolism. Severa...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2012/103072 |
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| author | Madhu N. Rao Morris Schambelan Viva W. Tai Donald I. Abrams Hootan Khatami Peter J. Havel Giorgos Sakkas Kathleen Mulligan |
| author_facet | Madhu N. Rao Morris Schambelan Viva W. Tai Donald I. Abrams Hootan Khatami Peter J. Havel Giorgos Sakkas Kathleen Mulligan |
| author_sort | Madhu N. Rao |
| collection | DOAJ |
| description | HIV-infected individuals are at risk for decreased bone mineral density (BMD). The known risk factors for bone loss do not fully explain the increased risk in this population. There is emerging evidence that leptin, a hormone secreted by adipocytes, plays an important role in bone metabolism. Several studies have assessed the relationship between leptin and bone density in healthy adults, but there are few such studies in HIV-infected individuals. Furthermore, HIV infected individuals on antiretroviral therapy are at increased risk for altered fat distribution, which may impact the relationship between leptin and BMD. In a cross-sectional analysis of data in 107 HIV-infected men, we determined whether serum leptin levels were associated with whole-body BMD and bone mineral content measured by dual-energy X-ray absorptiometry (DEXA), after adjusting for confounders including body fat distribution. We found an inverse association between leptin and bone density in those with peripheral lipoatrophy, defined objectively as <3 kg appendicular fat by DEXA, but no such relationship was seen in those with >3 kg appendicular fat. This result suggests that fat distribution may modify the relationship between leptin and bone density. |
| format | Article |
| id | doaj-art-996d1438de5948a09d1e8c2aa1259d84 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-996d1438de5948a09d1e8c2aa1259d842025-02-03T05:44:39ZengWileyAIDS Research and Treatment2090-12402090-12592012-01-01201210.1155/2012/103072103072Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected MenMadhu N. Rao0Morris Schambelan1Viva W. Tai2Donald I. Abrams3Hootan Khatami4Peter J. Havel5Giorgos Sakkas6Kathleen Mulligan7Department of Medicine, University of California, San Francisco, CA 94143, USADepartment of Medicine, University of California, San Francisco, CA 94143, USADivision of Endocrinology, San Francisco General Hospital, 1001 Potrero Avenue, Building 30 Room 3501K, San Francisco, CA 94110, USADepartment of Medicine, University of California, San Francisco, CA 94143, USADaiichi Sankyo Pharma Development, 399 Thornall Street N. 45, Edison, NJ 08837, USADepartment of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California, Davis, 1093 Haring Hall, Davis, CA 95616, USADepartment of Medicine, University General Hospital of Larissa, University of Thessaly, Mezourlo, TK 411-10 Larissa, GreeceDepartment of Medicine, University of California, San Francisco, CA 94143, USAHIV-infected individuals are at risk for decreased bone mineral density (BMD). The known risk factors for bone loss do not fully explain the increased risk in this population. There is emerging evidence that leptin, a hormone secreted by adipocytes, plays an important role in bone metabolism. Several studies have assessed the relationship between leptin and bone density in healthy adults, but there are few such studies in HIV-infected individuals. Furthermore, HIV infected individuals on antiretroviral therapy are at increased risk for altered fat distribution, which may impact the relationship between leptin and BMD. In a cross-sectional analysis of data in 107 HIV-infected men, we determined whether serum leptin levels were associated with whole-body BMD and bone mineral content measured by dual-energy X-ray absorptiometry (DEXA), after adjusting for confounders including body fat distribution. We found an inverse association between leptin and bone density in those with peripheral lipoatrophy, defined objectively as <3 kg appendicular fat by DEXA, but no such relationship was seen in those with >3 kg appendicular fat. This result suggests that fat distribution may modify the relationship between leptin and bone density.http://dx.doi.org/10.1155/2012/103072 |
| spellingShingle | Madhu N. Rao Morris Schambelan Viva W. Tai Donald I. Abrams Hootan Khatami Peter J. Havel Giorgos Sakkas Kathleen Mulligan Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men AIDS Research and Treatment |
| title | Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men |
| title_full | Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men |
| title_fullStr | Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men |
| title_full_unstemmed | Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men |
| title_short | Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men |
| title_sort | assessing the association between leptin and bone mineral density in hiv infected men |
| url | http://dx.doi.org/10.1155/2012/103072 |
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