Associations of cachexia and frailty with amyotrophic lateral sclerosis
Abstract In the present study, we investigated the associations of cachexia (loss of muscle, weight and fat) and frailty (loss of weight and muscle) status with the risk of developing amyotrophic lateral sclerosis, because these specific terms are rarely used in this research area. In this prospecti...
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Nature Portfolio
2025-02-01
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Online Access: | https://doi.org/10.1038/s41598-025-89080-3 |
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author | Tracy L. Peters Weihong Qiu Haomin Yang Wuqing Huang Yizhen Hu Zhangyu Zou Weimin Ye |
author_facet | Tracy L. Peters Weihong Qiu Haomin Yang Wuqing Huang Yizhen Hu Zhangyu Zou Weimin Ye |
author_sort | Tracy L. Peters |
collection | DOAJ |
description | Abstract In the present study, we investigated the associations of cachexia (loss of muscle, weight and fat) and frailty (loss of weight and muscle) status with the risk of developing amyotrophic lateral sclerosis, because these specific terms are rarely used in this research area. In this prospective study, we extracted cachexia and frailty status from the UK Biobank cohort to study the associations of these conditions (as determined via international classification of disease-10 codes) with amyotrophic lateral sclerosis. There was a greater risk of developing amyotrophic lateral sclerosis among individuals with cachexia and frailty status after adjusting for age, sex, income (pounds), body mass index, UK Biobank centers and smoking status. Among individuals with frailty status: a grip strength of < 21 kg, a slow walking speed, and exhaustion (more than half the days or nearly every day) increase the risk of developing amyotrophic lateral sclerosis. We believe that studying cachexia and frailty status can be used to help define and treat amyotrophic lateral sclerosis. |
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institution | Kabale University |
issn | 2045-2322 |
language | English |
publishDate | 2025-02-01 |
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spelling | doaj-art-996469999ed9415a8e9132e6b47917092025-02-09T12:34:46ZengNature PortfolioScientific Reports2045-23222025-02-011511910.1038/s41598-025-89080-3Associations of cachexia and frailty with amyotrophic lateral sclerosisTracy L. Peters0Weihong Qiu1Haomin Yang2Wuqing Huang3Yizhen Hu4Zhangyu Zou5Weimin Ye6Department of Neurology, Union Hospital, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical UniversityDepartment of Neurology, Union Hospital, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical UniversityAbstract In the present study, we investigated the associations of cachexia (loss of muscle, weight and fat) and frailty (loss of weight and muscle) status with the risk of developing amyotrophic lateral sclerosis, because these specific terms are rarely used in this research area. In this prospective study, we extracted cachexia and frailty status from the UK Biobank cohort to study the associations of these conditions (as determined via international classification of disease-10 codes) with amyotrophic lateral sclerosis. There was a greater risk of developing amyotrophic lateral sclerosis among individuals with cachexia and frailty status after adjusting for age, sex, income (pounds), body mass index, UK Biobank centers and smoking status. Among individuals with frailty status: a grip strength of < 21 kg, a slow walking speed, and exhaustion (more than half the days or nearly every day) increase the risk of developing amyotrophic lateral sclerosis. We believe that studying cachexia and frailty status can be used to help define and treat amyotrophic lateral sclerosis.https://doi.org/10.1038/s41598-025-89080-3Amyotrophic lateral sclerosisEpidemiologyFrailtyCachexia |
spellingShingle | Tracy L. Peters Weihong Qiu Haomin Yang Wuqing Huang Yizhen Hu Zhangyu Zou Weimin Ye Associations of cachexia and frailty with amyotrophic lateral sclerosis Scientific Reports Amyotrophic lateral sclerosis Epidemiology Frailty Cachexia |
title | Associations of cachexia and frailty with amyotrophic lateral sclerosis |
title_full | Associations of cachexia and frailty with amyotrophic lateral sclerosis |
title_fullStr | Associations of cachexia and frailty with amyotrophic lateral sclerosis |
title_full_unstemmed | Associations of cachexia and frailty with amyotrophic lateral sclerosis |
title_short | Associations of cachexia and frailty with amyotrophic lateral sclerosis |
title_sort | associations of cachexia and frailty with amyotrophic lateral sclerosis |
topic | Amyotrophic lateral sclerosis Epidemiology Frailty Cachexia |
url | https://doi.org/10.1038/s41598-025-89080-3 |
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