Associations of cachexia and frailty with amyotrophic lateral sclerosis

Abstract In the present study, we investigated the associations of cachexia (loss of muscle, weight and fat) and frailty (loss of weight and muscle) status with the risk of developing amyotrophic lateral sclerosis, because these specific terms are rarely used in this research area. In this prospecti...

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Main Authors: Tracy L. Peters, Weihong Qiu, Haomin Yang, Wuqing Huang, Yizhen Hu, Zhangyu Zou, Weimin Ye
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-89080-3
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author Tracy L. Peters
Weihong Qiu
Haomin Yang
Wuqing Huang
Yizhen Hu
Zhangyu Zou
Weimin Ye
author_facet Tracy L. Peters
Weihong Qiu
Haomin Yang
Wuqing Huang
Yizhen Hu
Zhangyu Zou
Weimin Ye
author_sort Tracy L. Peters
collection DOAJ
description Abstract In the present study, we investigated the associations of cachexia (loss of muscle, weight and fat) and frailty (loss of weight and muscle) status with the risk of developing amyotrophic lateral sclerosis, because these specific terms are rarely used in this research area. In this prospective study, we extracted cachexia and frailty status from the UK Biobank cohort to study the associations of these conditions (as determined via international classification of disease-10 codes) with amyotrophic lateral sclerosis. There was a greater risk of developing amyotrophic lateral sclerosis among individuals with cachexia and frailty status after adjusting for age, sex, income (pounds), body mass index, UK Biobank centers and smoking status. Among individuals with frailty status: a grip strength of < 21 kg, a slow walking speed, and exhaustion (more than half the days or nearly every day) increase the risk of developing amyotrophic lateral sclerosis. We believe that studying cachexia and frailty status can be used to help define and treat amyotrophic lateral sclerosis.
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spelling doaj-art-996469999ed9415a8e9132e6b47917092025-02-09T12:34:46ZengNature PortfolioScientific Reports2045-23222025-02-011511910.1038/s41598-025-89080-3Associations of cachexia and frailty with amyotrophic lateral sclerosisTracy L. Peters0Weihong Qiu1Haomin Yang2Wuqing Huang3Yizhen Hu4Zhangyu Zou5Weimin Ye6Department of Neurology, Union Hospital, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical UniversityDepartment of Neurology, Union Hospital, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical UniversityAbstract In the present study, we investigated the associations of cachexia (loss of muscle, weight and fat) and frailty (loss of weight and muscle) status with the risk of developing amyotrophic lateral sclerosis, because these specific terms are rarely used in this research area. In this prospective study, we extracted cachexia and frailty status from the UK Biobank cohort to study the associations of these conditions (as determined via international classification of disease-10 codes) with amyotrophic lateral sclerosis. There was a greater risk of developing amyotrophic lateral sclerosis among individuals with cachexia and frailty status after adjusting for age, sex, income (pounds), body mass index, UK Biobank centers and smoking status. Among individuals with frailty status: a grip strength of < 21 kg, a slow walking speed, and exhaustion (more than half the days or nearly every day) increase the risk of developing amyotrophic lateral sclerosis. We believe that studying cachexia and frailty status can be used to help define and treat amyotrophic lateral sclerosis.https://doi.org/10.1038/s41598-025-89080-3Amyotrophic lateral sclerosisEpidemiologyFrailtyCachexia
spellingShingle Tracy L. Peters
Weihong Qiu
Haomin Yang
Wuqing Huang
Yizhen Hu
Zhangyu Zou
Weimin Ye
Associations of cachexia and frailty with amyotrophic lateral sclerosis
Scientific Reports
Amyotrophic lateral sclerosis
Epidemiology
Frailty
Cachexia
title Associations of cachexia and frailty with amyotrophic lateral sclerosis
title_full Associations of cachexia and frailty with amyotrophic lateral sclerosis
title_fullStr Associations of cachexia and frailty with amyotrophic lateral sclerosis
title_full_unstemmed Associations of cachexia and frailty with amyotrophic lateral sclerosis
title_short Associations of cachexia and frailty with amyotrophic lateral sclerosis
title_sort associations of cachexia and frailty with amyotrophic lateral sclerosis
topic Amyotrophic lateral sclerosis
Epidemiology
Frailty
Cachexia
url https://doi.org/10.1038/s41598-025-89080-3
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