Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents.
<h4>Aims</h4>Coronary artery stents have profound effects on arterial function by altering fluid flow mass transport and wall shear stress. We developed a new integrated methodology to analyse the effects of stents on mass transport and shear stress to inform the design of haemodynamical...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0271469&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850134702712684544 |
|---|---|
| author | Luke Boldock Amanda Inzoli Silvia Bonardelli Sarah Hsiao Alberto Marzo Andrew Narracott Julian Gunn Gabriele Dubini Claudio Chiastra Ian Halliday Paul D Morris Paul C Evans Perrault C M |
| author_facet | Luke Boldock Amanda Inzoli Silvia Bonardelli Sarah Hsiao Alberto Marzo Andrew Narracott Julian Gunn Gabriele Dubini Claudio Chiastra Ian Halliday Paul D Morris Paul C Evans Perrault C M |
| author_sort | Luke Boldock |
| collection | DOAJ |
| description | <h4>Aims</h4>Coronary artery stents have profound effects on arterial function by altering fluid flow mass transport and wall shear stress. We developed a new integrated methodology to analyse the effects of stents on mass transport and shear stress to inform the design of haemodynamically-favourable stents.<h4>Methods and results</h4>Stents were deployed in model vessels followed by tracking of fluorescent particles under flow. Parallel analyses involved high-resolution micro-computed tomography scanning followed by computational fluid dynamics simulations to assess wall shear stress distribution. Several stent designs were analysed to assess whether the workflow was robust for diverse strut geometries. Stents had striking effects on fluid flow streamlines, flow separation or funnelling, and the accumulation of particles at areas of complex geometry that were tightly coupled to stent shape. CFD analysis revealed that stents had a major influence on wall shear stress magnitude, direction and distribution and this was highly sensitive to geometry.<h4>Conclusions</h4>Integration of particle tracking with CFD allows assessment of fluid flow and shear stress in stented arteries in unprecedented detail. Deleterious flow perturbations, such as accumulation of particles at struts and non-physiological shear stress, were highly sensitive to individual stent geometry. Novel designs for stents should be tested for mass transport and shear stress which are important effectors of vascular health and repair. |
| format | Article |
| id | doaj-art-9963fb28a6164e4f8513ff83c019bd93 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-9963fb28a6164e4f8513ff83c019bd932025-08-20T02:31:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01177e027146910.1371/journal.pone.0271469Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents.Luke BoldockAmanda InzoliSilvia BonardelliSarah HsiaoAlberto MarzoAndrew NarracottJulian GunnGabriele DubiniClaudio ChiastraIan HallidayPaul D MorrisPaul C EvansPerrault C M<h4>Aims</h4>Coronary artery stents have profound effects on arterial function by altering fluid flow mass transport and wall shear stress. We developed a new integrated methodology to analyse the effects of stents on mass transport and shear stress to inform the design of haemodynamically-favourable stents.<h4>Methods and results</h4>Stents were deployed in model vessels followed by tracking of fluorescent particles under flow. Parallel analyses involved high-resolution micro-computed tomography scanning followed by computational fluid dynamics simulations to assess wall shear stress distribution. Several stent designs were analysed to assess whether the workflow was robust for diverse strut geometries. Stents had striking effects on fluid flow streamlines, flow separation or funnelling, and the accumulation of particles at areas of complex geometry that were tightly coupled to stent shape. CFD analysis revealed that stents had a major influence on wall shear stress magnitude, direction and distribution and this was highly sensitive to geometry.<h4>Conclusions</h4>Integration of particle tracking with CFD allows assessment of fluid flow and shear stress in stented arteries in unprecedented detail. Deleterious flow perturbations, such as accumulation of particles at struts and non-physiological shear stress, were highly sensitive to individual stent geometry. Novel designs for stents should be tested for mass transport and shear stress which are important effectors of vascular health and repair.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0271469&type=printable |
| spellingShingle | Luke Boldock Amanda Inzoli Silvia Bonardelli Sarah Hsiao Alberto Marzo Andrew Narracott Julian Gunn Gabriele Dubini Claudio Chiastra Ian Halliday Paul D Morris Paul C Evans Perrault C M Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. PLoS ONE |
| title | Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. |
| title_full | Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. |
| title_fullStr | Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. |
| title_full_unstemmed | Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. |
| title_short | Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. |
| title_sort | integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0271469&type=printable |
| work_keys_str_mv | AT lukeboldock integratingparticletrackingwithcomputationalfluiddynamicstoassesshaemodynamicperturbationbycoronaryarterystents AT amandainzoli integratingparticletrackingwithcomputationalfluiddynamicstoassesshaemodynamicperturbationbycoronaryarterystents AT silviabonardelli integratingparticletrackingwithcomputationalfluiddynamicstoassesshaemodynamicperturbationbycoronaryarterystents AT sarahhsiao integratingparticletrackingwithcomputationalfluiddynamicstoassesshaemodynamicperturbationbycoronaryarterystents AT albertomarzo integratingparticletrackingwithcomputationalfluiddynamicstoassesshaemodynamicperturbationbycoronaryarterystents AT andrewnarracott integratingparticletrackingwithcomputationalfluiddynamicstoassesshaemodynamicperturbationbycoronaryarterystents AT juliangunn integratingparticletrackingwithcomputationalfluiddynamicstoassesshaemodynamicperturbationbycoronaryarterystents AT gabrieledubini integratingparticletrackingwithcomputationalfluiddynamicstoassesshaemodynamicperturbationbycoronaryarterystents AT claudiochiastra integratingparticletrackingwithcomputationalfluiddynamicstoassesshaemodynamicperturbationbycoronaryarterystents AT ianhalliday integratingparticletrackingwithcomputationalfluiddynamicstoassesshaemodynamicperturbationbycoronaryarterystents AT pauldmorris integratingparticletrackingwithcomputationalfluiddynamicstoassesshaemodynamicperturbationbycoronaryarterystents AT paulcevans integratingparticletrackingwithcomputationalfluiddynamicstoassesshaemodynamicperturbationbycoronaryarterystents AT perraultcm integratingparticletrackingwithcomputationalfluiddynamicstoassesshaemodynamicperturbationbycoronaryarterystents |