Glucocorticoid boluses followed by tocilizumab in giant cell arteritis patients: effects on peripheral blood monocytes and lymphocytes

Glucocorticoid boluses followed by tocilizumab in giant cell arteritis patients: effects on peripheral blood monocytes and lymphocytes

IntroductionGiant Cell Arteritis (GCA) is the most common vasculitis in the elderly, characterized by granulomatous infiltration of immune cells in medium and large arteries. A therapeutic protocol that combines ultra-short glucocorticoids (GC) followed by tocilizumab (TCZ) monotherapy has been prov...

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Main Authors: Cecilia Catellani, Martina Bonacini, Alessandro Rossi, Ilaria Ferrigno, Veronica Buia, Chiara Marvisi, Giulia Cassone, Mariagrazia Catanoso, Gabriella Di Tommaso, Luigi Boiardi, Rexhep Durmo, Annibale Versari, Massimiliano Casali, Giulia Besutti, Lucia Spaggiari, Alessandro Zerbini, Francesco Muratore, Carlo Salvarani, Stefania Croci
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
giant cell arteritis
glucocorticoids
tocilizumab
lymphocytes
monocytes
CCR2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1516008/full
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