Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>X<sub>0.1</sub>O<sub>4</sub> (X = Ce<sup>4+</sup>, Sm<sup>3+</sup>, Ho<sup>3+</sup>, and Er<sup>3+</sup>) Nanoparticles with Selective Anticancer Activity: A Structural and Morphological Approach
In this work, we synthesized the Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>X<sub>0.1</sub>O<sub>4</sub> (X = Ce<sup>3+</sup>, Sm<sup>3+</sup>, Ho<sup>3+</sup>, and Er<sup>3+</sup>) nan...
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MDPI AG
2025-05-01
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| Series: | Crystals |
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| Online Access: | https://www.mdpi.com/2073-4352/15/5/482 |
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| author | Liza Saher Adel Benali Saoussen Haddad Essebti Dhahri Manuel P. F. Graça Benilde F. O. Costa Luisa A. Helguero Artur M. S. Silva |
| author_facet | Liza Saher Adel Benali Saoussen Haddad Essebti Dhahri Manuel P. F. Graça Benilde F. O. Costa Luisa A. Helguero Artur M. S. Silva |
| author_sort | Liza Saher |
| collection | DOAJ |
| description | In this work, we synthesized the Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>X<sub>0.1</sub>O<sub>4</sub> (X = Ce<sup>3+</sup>, Sm<sup>3+</sup>, Ho<sup>3+</sup>, and Er<sup>3+</sup>) nanoparticles via the auto-combustion method. The cell viability against two breast cancer cells (MDA-MB-231 and T-47D cells) and the PC3 prostate cancer cells were carefully analyzed and correlated with the structural parameters and particle size values as well as the chemical composition. The produced compounds’ morphological and structural characteristics were performed using scanning transmission microscopy (TEM) and X-ray Diffraction (XRD). For all compounds, the analyses of the XRD experimental data revealed a structurally reversed cubic spinel with space group Fd-3m. All of the compounds had crystallites smaller than 45 nm which concorded well with the particle size values deduced from TEM images. Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>Ho<sub>0.1</sub>O<sub>4</sub> nanoparticles induced a high mortality of breast and prostate cancer cells (MDA-MB-231, T-47D, and PC3) while the Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>Sm<sub>0.1</sub>O<sub>4</sub> compound (higher particle size) reduced almost 35% of MDA-MB-231 cancer cells. With very low cytotoxicity against normal human cells, the Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>Ho<sub>0.1</sub>O<sub>4</sub> nanoparticles play a significant role in the elimination of cancer cells. |
| format | Article |
| id | doaj-art-994f4ec602c64210bb8b77996591ff7d |
| institution | Kabale University |
| issn | 2073-4352 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj-art-994f4ec602c64210bb8b77996591ff7d2025-08-20T03:47:49ZengMDPI AGCrystals2073-43522025-05-0115548210.3390/cryst15050482Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>X<sub>0.1</sub>O<sub>4</sub> (X = Ce<sup>4+</sup>, Sm<sup>3+</sup>, Ho<sup>3+</sup>, and Er<sup>3+</sup>) Nanoparticles with Selective Anticancer Activity: A Structural and Morphological ApproachLiza Saher0Adel Benali1Saoussen Haddad2Essebti Dhahri3Manuel P. F. Graça4Benilde F. O. Costa5Luisa A. Helguero6Artur M. S. Silva7LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalI3N, Physics Department, Campus de Santiago, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Chemistry, Faculty of Science, Northern Border University, Arar 91431, Saudi ArabiaLaboratoire de Physique Appliquée, Faculté des Sciences, Université de Sfax, B.P. 1171, Sfax 3000, TunisiaI3N, Physics Department, Campus de Santiago, University of Aveiro, 3810-193 Aveiro, PortugalUniversity of Coimbra, CFisUC, Physics Department, 3400-516 Coimbra, PortugalInstitute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, PortugalInstitute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, PortugalIn this work, we synthesized the Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>X<sub>0.1</sub>O<sub>4</sub> (X = Ce<sup>3+</sup>, Sm<sup>3+</sup>, Ho<sup>3+</sup>, and Er<sup>3+</sup>) nanoparticles via the auto-combustion method. The cell viability against two breast cancer cells (MDA-MB-231 and T-47D cells) and the PC3 prostate cancer cells were carefully analyzed and correlated with the structural parameters and particle size values as well as the chemical composition. The produced compounds’ morphological and structural characteristics were performed using scanning transmission microscopy (TEM) and X-ray Diffraction (XRD). For all compounds, the analyses of the XRD experimental data revealed a structurally reversed cubic spinel with space group Fd-3m. All of the compounds had crystallites smaller than 45 nm which concorded well with the particle size values deduced from TEM images. Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>Ho<sub>0.1</sub>O<sub>4</sub> nanoparticles induced a high mortality of breast and prostate cancer cells (MDA-MB-231, T-47D, and PC3) while the Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>Sm<sub>0.1</sub>O<sub>4</sub> compound (higher particle size) reduced almost 35% of MDA-MB-231 cancer cells. With very low cytotoxicity against normal human cells, the Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>Ho<sub>0.1</sub>O<sub>4</sub> nanoparticles play a significant role in the elimination of cancer cells.https://www.mdpi.com/2073-4352/15/5/482auto-combustionspinel ferritenanoparticlesbreast and prostate cancer cells |
| spellingShingle | Liza Saher Adel Benali Saoussen Haddad Essebti Dhahri Manuel P. F. Graça Benilde F. O. Costa Luisa A. Helguero Artur M. S. Silva Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>X<sub>0.1</sub>O<sub>4</sub> (X = Ce<sup>4+</sup>, Sm<sup>3+</sup>, Ho<sup>3+</sup>, and Er<sup>3+</sup>) Nanoparticles with Selective Anticancer Activity: A Structural and Morphological Approach Crystals auto-combustion spinel ferrite nanoparticles breast and prostate cancer cells |
| title | Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>X<sub>0.1</sub>O<sub>4</sub> (X = Ce<sup>4+</sup>, Sm<sup>3+</sup>, Ho<sup>3+</sup>, and Er<sup>3+</sup>) Nanoparticles with Selective Anticancer Activity: A Structural and Morphological Approach |
| title_full | Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>X<sub>0.1</sub>O<sub>4</sub> (X = Ce<sup>4+</sup>, Sm<sup>3+</sup>, Ho<sup>3+</sup>, and Er<sup>3+</sup>) Nanoparticles with Selective Anticancer Activity: A Structural and Morphological Approach |
| title_fullStr | Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>X<sub>0.1</sub>O<sub>4</sub> (X = Ce<sup>4+</sup>, Sm<sup>3+</sup>, Ho<sup>3+</sup>, and Er<sup>3+</sup>) Nanoparticles with Selective Anticancer Activity: A Structural and Morphological Approach |
| title_full_unstemmed | Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>X<sub>0.1</sub>O<sub>4</sub> (X = Ce<sup>4+</sup>, Sm<sup>3+</sup>, Ho<sup>3+</sup>, and Er<sup>3+</sup>) Nanoparticles with Selective Anticancer Activity: A Structural and Morphological Approach |
| title_short | Co<sub>0.85</sub>Bi<sub>0.15</sub>Fe<sub>1.9</sub>X<sub>0.1</sub>O<sub>4</sub> (X = Ce<sup>4+</sup>, Sm<sup>3+</sup>, Ho<sup>3+</sup>, and Er<sup>3+</sup>) Nanoparticles with Selective Anticancer Activity: A Structural and Morphological Approach |
| title_sort | co sub 0 85 sub bi sub 0 15 sub fe sub 1 9 sub x sub 0 1 sub o sub 4 sub x ce sup 4 sup sm sup 3 sup ho sup 3 sup and er sup 3 sup nanoparticles with selective anticancer activity a structural and morphological approach |
| topic | auto-combustion spinel ferrite nanoparticles breast and prostate cancer cells |
| url | https://www.mdpi.com/2073-4352/15/5/482 |
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