Actoprotective activity of 5-(2-bromophenyl)-4-amino-4H-1,2,4-triazole-3-thione and its S-derivatives

Actoprotective activity of 5-(2-bromophenyl)-4-amino-4H-1,2,4-triazole-3-thione and its S-derivatives

Aim. The paper shows the actoprotective (anti-fatigue), activity of 1,2,4-triazole derivatives. Methods and results. The analysis of action was conducted for the synthesized 2-(5-(2-bromphenyl)-4-amino-4H-1,2,4-triazol-3-ylthio) acetic acid salts. We have revealed some patterns regarding to the c...

Full description

Saved in:

Bibliographic Details
Main Author:	Ye. S. Pruglo
Format:	Article
Language:	English
Published:	Zaporizhzhia State Medical and Pharmaceutical University 2016-04-01
Series:	Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Subjects:	Riboxin Anti-Fatigue Activities 1 2 4-triazole Weight Loaded Forced Swimming Test
Online Access:	http://pharmed.zsmu.edu.ua/article/view/61438/58069
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Actoprotective activity of 2-(4-r-3-(thiophen-2-yl)-4h-1,2,4-triazol-3-ylthio) acetic acid
by: V. O. Salionov, et al.
Published: (2017-03-01)

Actoprotective activity research of 2-((5-(2-bromophenyl)-4-substituted-4H-1,2,4-triazole-3-yl)thio)acetates
by: A. A. Safonov, et al.
Published: (2020-09-01)

Synthesis of novel 3-(2-bromophenyl)-4-substituted-1H-1,2,4-triazole-5(4H)-thiones derivatives
by: A. A. Safonov, et al.
Published: (2020-05-01)

Analgesic activity of 4-amino-5-methyl-4H-1,2,4-triazol-3-thiones
by: T. V. Kravchenko, et al.
Published: (2018-10-01)

ACUTE TOXICITYOF 4-AMINO-5-(2-, 3-, 4-NITROPHENYL)-1,2,4-TRIAZOLE-3-THIONES AND ITS DERIVATIVES
by: М. O. Shcherbak, et al.
Published: (2014-12-01)

Antidepressant activity of 4-amino-5-(alkyl-, aryl-, heteryl)-1,2,4-triazole-3-thione benzylidene derivatives
by: Ye. S. Pruhlo
Published: (2018-10-01)

Synthesis methods of 1,2,4-triazole-3-thiones: review
by: Yu. S. Frolova, et al.
Published: (2024-06-01)

Effect of 4-benzylidenamino-5-phenyl-4Н-1,2,4-triazole-3-thiones and salts of 2-(4-amino-5-phenyl-4Н-1,2,4-triazole-3-ylthio)acetic acid on central component of nociceptive system
by: Ye. S. Pruhlo
Published: (2016-08-01)

Synthesis and structure of new 4-amino-5-(2-R1-phenyl)-1,2,4-triazole-3-thiol alkilderivatives
by: Ye. S. Pruglo
Published: (2017-08-01)

Actoprotective properties of 7'-((3-thio-4-methyl-4H-1,2,4-triazole-5-yl)methyl)theophylline derivatives
by: A. S. Gotsulya
Published: (2016-06-01)

Antioxidant activity of salts of 2-(5-R-4-amino-1,2,4-triazole-3-ylthio)acetic acid
by: Ye. S. Pruglo
Published: (2017-12-01)

Synthesis, physical-chemical properties and the study of anti-hypoxemic activity of 5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-thion alkylderivatives
by: V. M. Odyntsova, et al.
Published: (2015-04-01)

The study of analgesic effect of 5-(furan-2-yl, 2-methylfuran-3-yl)-4-amino-1,2,4-triazole-3-thion derivatives
by: D. M. Danilchenko
Published: (2018-10-01)

Synthesis and research of the physical-chemical properties of 5-((2-bromphenyl)-4-amino-4H-1,2,4-triazole-3-ylthio)acetic acid salts
by: Ye. S. Pruglo
Published: (2018-03-01)

DFT-analysis of protolytic equivalents of 5-(aryl)-4-(methyl,amino)-1,2,4-triazole-3(2H)-thione
by: O. A. Bihdan, et al.
Published: (2022-08-01)

Diuretic activity of 3-(5-bromfuran-2-yl)-4-r-(4h)-1,2,4-triazole-5-thione, their S-derivatives and 2-(5-bromfuran-2-yl)-5-r'-thiazolo[3,2-b][1,2,4]triazole-6(5h)-ones
by: Ye. S. Pruglo, et al.
Published: (2015-12-01)

The research of acute toxicity of 4-amino-5-(4-(tert-butyl)phenyl)-4H-1,2,4-triazoles-3-thiol derivatives
by: I. I. Аksyonova-Seliuk, et al.
Published: (2017-08-01)

Synthesis and structure of some new Schiff bases, derivatives of 2-((4-((R-benzylidene)amino)-5-(2-fluorophenyl)-4H-1,2,4-triazole-3-yl)thio)acetohydrazides
by: Ye. S. Pruglo
Published: (2018-08-01)

Synthesis, antimicrobial and antifungal activity of 3-(2-bromophenyl)-5-(alkylthio)-4-phenyl-4H-1,2,4-triazoles
by: A. A. Safonov, et al.
Published: (2022-12-01)

Synthesis and actoprotective activity of salts of 2-(5-(4-metoxyphenіl (3,4,5-trimetoxyphenyl))-1,2,4-trіazole-3-ylthio)acetic acids
by: Yu. G. Samelyuk, et al.
Published: (2014-04-01)

In silico study of new bis-3R, 4R′-5-(((1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thione derivatives
by: Ye. O. Karpun, et al.
Published: (2019-12-01)

A study of actoprotective activity of new 3-(thiophen-2-ylmethyl)-1H-1,2,4-triazole-5-thiol derivatives
by: A. A. Safonov
Published: (2020-11-01)

Acute toxicity of 5-(2-, 3-, 4-methoxyphenyl, (3,4,5-trimethoxyphenyl)-)-1,2,4-triazole-3-thiones and its thioderivatives
by: Yu. G. Samelyuk, et al.
Published: (2015-12-01)

Search of potential antidiabetic drugs in range of 5-(phenoxymethylene)-4-R-1,2,4-triazole-3-thions
by: Yu. M. Kucheryavyi
Published: (2016-08-01)

Establishment of diuretic activity indicators for (3-thio-4-R-4-H-1,2,4-triazole-5-yl)(phenyl)methanols and their derivatives
by: A. M. Rud, et al.
Published: (2018-08-01)

A study of antimicrobial and antifungal activity of 2-((5-(2-bromophenyl)-4-substituted-4H-1,2,4-triazol-3-yl)thio)acetates
by: A. A. Safonov, et al.
Published: (2020-11-01)

Synthesis and properties of 5-(((5-amino-1,3,4-thiadiazole-2-yl)thio)methyl)-4-phenyl-1,2,4-triazole-3-thione and its some S-derivatives
by: A. S. Hotsulia, et al.
Published: (2020-08-01)

The search for new 4-amino-5-methyl-4H-1,2,4-triasole-3-thion derivatives with diuretic activity
by: T. V. Kravchenko
Published: (2018-06-01)

Chemical properties of amino- and thio-derivatives of 1,2,4-triazoles
by: A. G. Kaplaushenko
Published: (2015-04-01)

Diuretic activity of 2-((4-amino-5-R-4H-1,2,4-triazole-3-yl)thio)acetohydrazides
by: D. M. Danilchenko, et al.
Published: (2017-08-01)

Synthesis and properties of some S-derivatives of 4-phenyl-5-((5-phenylamino-1,3,4-thiadiazole-2-ylthio)methyl)-1,2,4-triazole-3-thione
by: A. S. Hotsulia, et al.
Published: (2019-12-01)

The study of the effect of 5-(4-(tret-butyl)phenyl)-4-R-amino-4H-1,2,4-triazole-3-thiols on the duration of thiopental-sodium narcosis for laboratory rats
by: I. I. Aksyonova-Seliuk, et al.
Published: (2016-10-01)

Antiradical activity of novel 4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol derivatives
by: A. A. Safonov, et al.
Published: (2021-07-01)

Anti-inflammatory activity of 2-(5-((theophylline-7'-yl)methyl)-4-R-4H-1,2,4-triazole-3-ylthio)acetic acid salts
by: A. S. Gotsulya, et al.
Published: (2014-12-01)

Synthesis, physical-chemical properties and further transformation of 5-(quinoline-2-yl, 2-hydroxyquinoline-4-yl)-4-R-2,4-dyhydro-3Н-1,2,4-triazole-3-thiones
by: T. M. Kaplaushenko
Published: (2016-08-01)

Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives
by: O. A. Bihdan, et al.
Published: (2017-08-01)

Synthesis of ylidene derivatives of 4-amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazole-3-thiol
by: I. I. Aksionova, et al.
Published: (2015-08-01)

Antimicrobial activity of new 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol derivatives
by: D. M. Danilchenko, et al.
Published: (2017-02-01)

Acute toxicity and "structure-action" dependence of 4-(R-benzylidenamino)-5-methyl-4H-1,2,4-triazoles 3-tion
by: T. V. Kravchenko, et al.
Published: (2017-08-01)

The acute toxicity of 5-thio-substituted 3-(5-bromofuran-2-yl)-4-ethyl-(4H)-1,2,4-triazole derivatives
by: E. S. Pruglo, et al.
Published: (2015-08-01)