Actoprotective activity of 5-(2-bromophenyl)-4-amino-4H-1,2,4-triazole-3-thione and its S-derivatives
Aim. The paper shows the actoprotective (anti-fatigue), activity of 1,2,4-triazole derivatives. Methods and results. The analysis of action was conducted for the synthesized 2-(5-(2-bromphenyl)-4-amino-4H-1,2,4-triazol-3-ylthio) acetic acid salts. We have revealed some patterns regarding to the c...
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| Format: | Article |
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Zaporizhzhia State Medical and Pharmaceutical University
2016-04-01
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| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
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| Online Access: | http://pharmed.zsmu.edu.ua/article/view/61438/58069 |
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| author | Ye. S. Pruglo |
| author_facet | Ye. S. Pruglo |
| author_sort | Ye. S. Pruglo |
| collection | DOAJ |
| description | Aim. The paper shows the actoprotective (anti-fatigue), activity of 1,2,4-triazole derivatives.
Methods and results. The analysis of action was conducted for the synthesized 2-(5-(2-bromphenyl)-4-amino-4H-1,2,4-triazol-3-ylthio) acetic acid salts. We have revealed some patterns regarding to the chemical structure and pharmacological action of the test substances.
Thus, in the research we have found that the most active compound among the studied was morpholinium 2-(5-(2-bromphenyl)-4-amino-4H-1,2,4-triazol-3-ylthio) acetate (3j), which increases the duration of rats (forced swimming with the load) as compared with the control group at 77,17% (p˂0,05), while the reference drug increases the rate at 24,16% (p˂0,05).
We have noted the compound 3i which exceed its activity comparing to Riboxinum at 23,2%, with increased endurance during the animals forced swimming test to 47,36% (p˂0,05).
Conclusions. It is marked that the parent thione 1a and its derivative of 2-(5-(2-bromophenyl)-4-amino-4H-1,2,4-triazol-3-ylthio) acetic acid salt 2a and 3d, 3e, 3f have no actoprotective properties in their application.
After analyzing the data of experimental studies some laws concerning the chemical structure and pharmacological action of the test substance have been established. |
| format | Article |
| id | doaj-art-994a2b6b82c64c2aa48bc04b93d10aa9 |
| institution | Kabale University |
| issn | 2306-8094 2409-2932 |
| language | English |
| publishDate | 2016-04-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| spelling | doaj-art-994a2b6b82c64c2aa48bc04b93d10aa92025-08-20T03:35:23ZengZaporizhzhia State Medical and Pharmaceutical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322016-04-011677010.14739/2409-2932.2016.1.61438Actoprotective activity of 5-(2-bromophenyl)-4-amino-4H-1,2,4-triazole-3-thione and its S-derivativesYe. S. PrugloAim. The paper shows the actoprotective (anti-fatigue), activity of 1,2,4-triazole derivatives. Methods and results. The analysis of action was conducted for the synthesized 2-(5-(2-bromphenyl)-4-amino-4H-1,2,4-triazol-3-ylthio) acetic acid salts. We have revealed some patterns regarding to the chemical structure and pharmacological action of the test substances. Thus, in the research we have found that the most active compound among the studied was morpholinium 2-(5-(2-bromphenyl)-4-amino-4H-1,2,4-triazol-3-ylthio) acetate (3j), which increases the duration of rats (forced swimming with the load) as compared with the control group at 77,17% (p˂0,05), while the reference drug increases the rate at 24,16% (p˂0,05). We have noted the compound 3i which exceed its activity comparing to Riboxinum at 23,2%, with increased endurance during the animals forced swimming test to 47,36% (p˂0,05). Conclusions. It is marked that the parent thione 1a and its derivative of 2-(5-(2-bromophenyl)-4-amino-4H-1,2,4-triazol-3-ylthio) acetic acid salt 2a and 3d, 3e, 3f have no actoprotective properties in their application. After analyzing the data of experimental studies some laws concerning the chemical structure and pharmacological action of the test substance have been established.http://pharmed.zsmu.edu.ua/article/view/61438/58069RiboxinAnti-Fatigue Activities1 2 4-triazoleWeight Loaded Forced Swimming Test |
| spellingShingle | Ye. S. Pruglo Actoprotective activity of 5-(2-bromophenyl)-4-amino-4H-1,2,4-triazole-3-thione and its S-derivatives Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki Riboxin Anti-Fatigue Activities 1 2 4-triazole Weight Loaded Forced Swimming Test |
| title | Actoprotective activity of 5-(2-bromophenyl)-4-amino-4H-1,2,4-triazole-3-thione and its S-derivatives |
| title_full | Actoprotective activity of 5-(2-bromophenyl)-4-amino-4H-1,2,4-triazole-3-thione and its S-derivatives |
| title_fullStr | Actoprotective activity of 5-(2-bromophenyl)-4-amino-4H-1,2,4-triazole-3-thione and its S-derivatives |
| title_full_unstemmed | Actoprotective activity of 5-(2-bromophenyl)-4-amino-4H-1,2,4-triazole-3-thione and its S-derivatives |
| title_short | Actoprotective activity of 5-(2-bromophenyl)-4-amino-4H-1,2,4-triazole-3-thione and its S-derivatives |
| title_sort | actoprotective activity of 5 2 bromophenyl 4 amino 4h 1 2 4 triazole 3 thione and its s derivatives |
| topic | Riboxin Anti-Fatigue Activities 1 2 4-triazole Weight Loaded Forced Swimming Test |
| url | http://pharmed.zsmu.edu.ua/article/view/61438/58069 |
| work_keys_str_mv | AT yespruglo actoprotectiveactivityof52bromophenyl4amino4h124triazole3thioneanditssderivatives |