A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults

ObjectiveThis study aims to investigate the potential association between serum 25(OH)D levels and the risk of hyperlipidemia in adults through a prospective cohort study conducted in Zhejiang Province.MethodsBaseline surveys and follow-up studies were conducted to collect and analyze follow-up data...

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Main Authors: Zi-yue Liu, Sha Liu, Xue Yao, Chun-yang Wang, Yunhao Song, Yan-ming Bi, Jin-Xiu Wang, Yang Li, Ta-la Shi, Wei Mi, Caiyun Chen, Zhi-Yong Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Nutrition
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Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2024.1492621/full
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author Zi-yue Liu
Sha Liu
Xue Yao
Chun-yang Wang
Yunhao Song
Yan-ming Bi
Jin-Xiu Wang
Yang Li
Ta-la Shi
Wei Mi
Caiyun Chen
Zhi-Yong Hu
author_facet Zi-yue Liu
Sha Liu
Xue Yao
Chun-yang Wang
Yunhao Song
Yan-ming Bi
Jin-Xiu Wang
Yang Li
Ta-la Shi
Wei Mi
Caiyun Chen
Zhi-Yong Hu
author_sort Zi-yue Liu
collection DOAJ
description ObjectiveThis study aims to investigate the potential association between serum 25(OH)D levels and the risk of hyperlipidemia in adults through a prospective cohort study conducted in Zhejiang Province.MethodsBaseline surveys and follow-up studies were conducted to collect and analyze follow-up data over a three-year period. Vitamin D deficiency was defined as 25(OH)D < 20 ng/mL, insufficiency as 20–29 ng/mL, and sufficiency as 25(OH)D ≥ 30 ng/mL. Hyperlipidemia or dyslipidemia was defined as the presence of hypercholesterolemia, hypertriglyceridemia, or both. The relationship between demographic characteristics and the incidence of hyperlipidemia among the study participants was explored.ResultsA total of 1,210 participants were included in this study, with 43.80% being male. The mean age of the participants was 51.84 ± 14.37 years, and the average serum 25(OH)D level was 25.89 (21.50, 29.82) ng/mL. A significant difference in the proportion of vitamin D deficiency was observed between males and females (22.06% vs. 10.94%, p < 0.001). Vitamin D deficiency and insufficiency were prevalent among the middle-aged and elderly population (78.24%). Significant differences were found between the two groups in multiple sociodemographic variables, behavioral factors, and metabolic risk factors (p < 0.05). The incidence of hyperlipidemia among vitamin D-deficient individuals was 1.612 times higher than that among vitamin D-sufficient individuals (95% confidence interval [CI]: 1.228–2.116; p < 0.001). After fully adjusting for confounding factors, the multivariate-adjusted hazard ratio (HR) was 1.572 (95% CI: 1.187–2.08; p = 0.002), indicating a difference in the incidence of hyperlipidemia across different serum vitamin D levels.ConclusionThis cohort study reveals a significant association between serum 25(OH)D levels and the incidence of hyperlipidemia. Additionally, lifestyle factors associated with vitamin D deficiency are also correlated with the incidence of hyperlipidemia. These findings provide further evidence for improving blood lipid profiles through adjustments in vitamin D intake or related lifestyle modifications.
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spelling doaj-art-994855460ed24c9e833703d277a03e002025-01-24T04:11:09ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.14926211492621A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adultsZi-yue Liu0Sha Liu1Xue Yao2Chun-yang Wang3Yunhao Song4Yan-ming Bi5Jin-Xiu Wang6Yang Li7Ta-la Shi8Wei Mi9Caiyun Chen10Zhi-Yong Hu11School of Public Health, Binzhou Medical University, Yantai, ChinaSchool of Public Health, Binzhou Medical University, Yantai, ChinaSchool of Public Health, Binzhou Medical University, Yantai, ChinaSchool of Public Health, Binzhou Medical University, Yantai, ChinaYantai Affiliated Hospital of Binzhou Medical College, Yantai, ChinaSchool of Public Health, Binzhou Medical University, Yantai, ChinaSchool of Public Health, Binzhou Medical University, Yantai, ChinaOccupation of Chinese Center for Disease Control and Prevention, Beijing, ChinaSchool of Public Health, Binzhou Medical University, Yantai, ChinaSchool of Public Health, Binzhou Medical University, Yantai, ChinaSchool of Public Health, Binzhou Medical University, Yantai, ChinaSchool of Public Health, Binzhou Medical University, Yantai, ChinaObjectiveThis study aims to investigate the potential association between serum 25(OH)D levels and the risk of hyperlipidemia in adults through a prospective cohort study conducted in Zhejiang Province.MethodsBaseline surveys and follow-up studies were conducted to collect and analyze follow-up data over a three-year period. Vitamin D deficiency was defined as 25(OH)D < 20 ng/mL, insufficiency as 20–29 ng/mL, and sufficiency as 25(OH)D ≥ 30 ng/mL. Hyperlipidemia or dyslipidemia was defined as the presence of hypercholesterolemia, hypertriglyceridemia, or both. The relationship between demographic characteristics and the incidence of hyperlipidemia among the study participants was explored.ResultsA total of 1,210 participants were included in this study, with 43.80% being male. The mean age of the participants was 51.84 ± 14.37 years, and the average serum 25(OH)D level was 25.89 (21.50, 29.82) ng/mL. A significant difference in the proportion of vitamin D deficiency was observed between males and females (22.06% vs. 10.94%, p < 0.001). Vitamin D deficiency and insufficiency were prevalent among the middle-aged and elderly population (78.24%). Significant differences were found between the two groups in multiple sociodemographic variables, behavioral factors, and metabolic risk factors (p < 0.05). The incidence of hyperlipidemia among vitamin D-deficient individuals was 1.612 times higher than that among vitamin D-sufficient individuals (95% confidence interval [CI]: 1.228–2.116; p < 0.001). After fully adjusting for confounding factors, the multivariate-adjusted hazard ratio (HR) was 1.572 (95% CI: 1.187–2.08; p = 0.002), indicating a difference in the incidence of hyperlipidemia across different serum vitamin D levels.ConclusionThis cohort study reveals a significant association between serum 25(OH)D levels and the incidence of hyperlipidemia. Additionally, lifestyle factors associated with vitamin D deficiency are also correlated with the incidence of hyperlipidemia. These findings provide further evidence for improving blood lipid profiles through adjustments in vitamin D intake or related lifestyle modifications.https://www.frontiersin.org/articles/10.3389/fnut.2024.1492621/fullvitamin Dhyperlipidaemiacohort study25(OH)Dadults
spellingShingle Zi-yue Liu
Sha Liu
Xue Yao
Chun-yang Wang
Yunhao Song
Yan-ming Bi
Jin-Xiu Wang
Yang Li
Ta-la Shi
Wei Mi
Caiyun Chen
Zhi-Yong Hu
A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults
Frontiers in Nutrition
vitamin D
hyperlipidaemia
cohort study
25(OH)D
adults
title A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults
title_full A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults
title_fullStr A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults
title_full_unstemmed A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults
title_short A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults
title_sort cohort study of serum 25 hydroxyvitamin d levels and the risk of hyperlipidaemia in adults
topic vitamin D
hyperlipidaemia
cohort study
25(OH)D
adults
url https://www.frontiersin.org/articles/10.3389/fnut.2024.1492621/full
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