Synthesis of Transition Metal-Nanochitosan Composites Using Ni, Cu, Zn, and Ag Metal Ions and Applications as Antibacterial Agents
Nanocomposites are used as antibacterial agents in the pharmacology sector. Therefore, this research aimed to investigate the synthesis, characterization, and antibacterial activity of the transition metal-nanochitosan composites (TM-NCs) using Ni (nickel), Cu (cuprum), Zn (zinc), and Ag (silver) as...
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| Format: | Article |
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Universitas Indonesia
2025-01-01
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| Series: | International Journal of Technology |
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| Online Access: | https://ijtech.eng.ui.ac.id/article/view/6969 |
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| author | Khoirina Dwi Nugrahaningtyas Eny Kusrini Salwa Salsabila Dina Fitriana Anwar Usman Triana Kusumaningsih Sri Juari Santoso |
| author_facet | Khoirina Dwi Nugrahaningtyas Eny Kusrini Salwa Salsabila Dina Fitriana Anwar Usman Triana Kusumaningsih Sri Juari Santoso |
| author_sort | Khoirina Dwi Nugrahaningtyas |
| collection | DOAJ |
| description | Nanocomposites are used as antibacterial agents in the pharmacology sector. Therefore, this research aimed to investigate the synthesis, characterization, and antibacterial activity of the transition metal-nanochitosan composites (TM-NCs) using Ni (nickel), Cu (cuprum), Zn (zinc), and Ag (silver) as TM and nanochitosan as the nanomaterial. TM-NCs were synthesized using precipitation method with sodium tripolyphosphate (STPP) as a cross-linking agent. The synthesized products were characterized using X-ray Fluorescence (XRF), X-ray Diffraction (XRD), Fourier Transform Infrared (FTIR), and Scanning Electron Microscopy (SEM) instruments. The metal phase attached to NCs was a metal oxide with irregular particle shapes and various particle sizes. Meanwhile, chitosan and STPP functional groups, namely NH2 and P-O were bound to the metal to form TM-NCs nanocomposite. The test for antibacterial activity against gram-positive (Streptococcus pyogenes ATCC 19615 and Bacillus cereus ATCC 10556) and gram-negative (Escherichia coli ATCC 11229 and Klebsiella pneumoniae ATCC 13883) bacterial strains was carried out using the well-diffusion method. The results showed that Ni-NCs antibacterial activity had the largest inhibition zone compared to the other TM-NCs. Furthermore, Ni-NCs presented the largest inhibitory zone diameter (21.74 mm) towards the gram-positive bacterium S. pyogenes. |
| format | Article |
| id | doaj-art-994772f960344c30be220dec299df335 |
| institution | Kabale University |
| issn | 2086-9614 2087-2100 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | International Journal of Technology |
| spelling | doaj-art-994772f960344c30be220dec299df3352025-01-31T14:13:03ZengUniversitas IndonesiaInternational Journal of Technology2086-96142087-21002025-01-0116120722010.14716/ijtech.v16i1.69696969Synthesis of Transition Metal-Nanochitosan Composites Using Ni, Cu, Zn, and Ag Metal Ions and Applications as Antibacterial AgentsKhoirina Dwi Nugrahaningtyas0Eny Kusrini1Salwa Salsabila2Dina Fitriana3Anwar Usman4Triana Kusumaningsih5Sri Juari Santoso6Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sebelas Maret University, Surakarta, 57124 Indonesia1. Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus Baru UI, Depok 16424, Indonesia 2. Research Group of Green Product and Fine Chemical Engineering, Laborato1. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sebelas Maret University, Surakarta, 57124 IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Sebelas Maret University, Surakarta, 57124 IndonesiaDepartment of Chemistry, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, Brunei DarussalamDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Sebelas Maret University, Surakarta, 57124 IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaNanocomposites are used as antibacterial agents in the pharmacology sector. Therefore, this research aimed to investigate the synthesis, characterization, and antibacterial activity of the transition metal-nanochitosan composites (TM-NCs) using Ni (nickel), Cu (cuprum), Zn (zinc), and Ag (silver) as TM and nanochitosan as the nanomaterial. TM-NCs were synthesized using precipitation method with sodium tripolyphosphate (STPP) as a cross-linking agent. The synthesized products were characterized using X-ray Fluorescence (XRF), X-ray Diffraction (XRD), Fourier Transform Infrared (FTIR), and Scanning Electron Microscopy (SEM) instruments. The metal phase attached to NCs was a metal oxide with irregular particle shapes and various particle sizes. Meanwhile, chitosan and STPP functional groups, namely NH2 and P-O were bound to the metal to form TM-NCs nanocomposite. The test for antibacterial activity against gram-positive (Streptococcus pyogenes ATCC 19615 and Bacillus cereus ATCC 10556) and gram-negative (Escherichia coli ATCC 11229 and Klebsiella pneumoniae ATCC 13883) bacterial strains was carried out using the well-diffusion method. The results showed that Ni-NCs antibacterial activity had the largest inhibition zone compared to the other TM-NCs. Furthermore, Ni-NCs presented the largest inhibitory zone diameter (21.74 mm) towards the gram-positive bacterium S. pyogenes.https://ijtech.eng.ui.ac.id/article/view/6969antibacterialchitosancross-linking agentnanocompositetransition metaltransition metal-nanochitosan |
| spellingShingle | Khoirina Dwi Nugrahaningtyas Eny Kusrini Salwa Salsabila Dina Fitriana Anwar Usman Triana Kusumaningsih Sri Juari Santoso Synthesis of Transition Metal-Nanochitosan Composites Using Ni, Cu, Zn, and Ag Metal Ions and Applications as Antibacterial Agents International Journal of Technology antibacterial chitosan cross-linking agent nanocomposite transition metal transition metal-nanochitosan |
| title | Synthesis of Transition Metal-Nanochitosan Composites Using Ni, Cu, Zn, and Ag Metal Ions and Applications as Antibacterial Agents |
| title_full | Synthesis of Transition Metal-Nanochitosan Composites Using Ni, Cu, Zn, and Ag Metal Ions and Applications as Antibacterial Agents |
| title_fullStr | Synthesis of Transition Metal-Nanochitosan Composites Using Ni, Cu, Zn, and Ag Metal Ions and Applications as Antibacterial Agents |
| title_full_unstemmed | Synthesis of Transition Metal-Nanochitosan Composites Using Ni, Cu, Zn, and Ag Metal Ions and Applications as Antibacterial Agents |
| title_short | Synthesis of Transition Metal-Nanochitosan Composites Using Ni, Cu, Zn, and Ag Metal Ions and Applications as Antibacterial Agents |
| title_sort | synthesis of transition metal nanochitosan composites using ni cu zn and ag metal ions and applications as antibacterial agents |
| topic | antibacterial chitosan cross-linking agent nanocomposite transition metal transition metal-nanochitosan |
| url | https://ijtech.eng.ui.ac.id/article/view/6969 |
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