Routine Pulmonary Function Test Can Estimate the Extent of Tuberculous Destroyed Lung
Tuberculous destroyed lung (TDL) is diagnosed by a clear past history of tuberculosis with findings of parenchymal destruction verified by chest X-ray. Despite the resultant deterioration of lung function and quality of lives seen in TDL patients, the exact mechanism or characteristics of pulmonary...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/835031 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849404263013285888 |
|---|---|
| author | Eun Joo Lee Sang Yeub Lee Kwang Ho In Se Hwa Yoo Eun Jeong Choi Yu Whan Oh Sanghoon Park |
| author_facet | Eun Joo Lee Sang Yeub Lee Kwang Ho In Se Hwa Yoo Eun Jeong Choi Yu Whan Oh Sanghoon Park |
| author_sort | Eun Joo Lee |
| collection | DOAJ |
| description | Tuberculous destroyed lung (TDL) is diagnosed by a clear past history of tuberculosis with findings of parenchymal destruction verified by chest X-ray. Despite the resultant deterioration of lung function and quality of lives seen in TDL patients, the exact mechanism or characteristics of pulmonary function worsening have not been clearly studied. We investigated the feature of respiratory impairment of TDL patients, and studied whether extent of destroyed lung measured with chest CT has any correlation with routine lung function. To evaluate the degree of destruction, the Goddard classification scoring system was modified into a novel scoring system (destroyed lung score, (DLS)) with a score from 0 to 4. Twenty-five subjects were enrolled. TDL predominantly manifested as an obstructive pattern (64%, 16/25). Median value of DLS of the entire lung was 2.6 (1.7–3.9). Absolute values of FEV1 and FVC were both negatively associated with DLS (r=-0.78, P=0.001, and r=-0.61, P=0.021). Percentage of predicted value of FEV1 and FVC were also negatively associated with DLS (r=-0.62, P=0.019, and r=-0.76, P=0.002). Our study shows that lung function of TDL patients were notably correlated with the extent of destroyed lung measured with chest CT scan. |
| format | Article |
| id | doaj-art-9945cb2fb45e4fcbbaee3c4b3d26049f |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9945cb2fb45e4fcbbaee3c4b3d26049f2025-08-20T03:37:03ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/835031835031Routine Pulmonary Function Test Can Estimate the Extent of Tuberculous Destroyed LungEun Joo Lee0Sang Yeub Lee1Kwang Ho In2Se Hwa Yoo3Eun Jeong Choi4Yu Whan Oh5Sanghoon Park6Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul 136-705, Republic of KoreaDivision of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul 136-705, Republic of KoreaDivision of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul 136-705, Republic of KoreaDivision of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul 136-705, Republic of KoreaDepartment of Radiology, Korea University Anam Hospital, Korea University College of Medicine, Seoul 136-705, Republic of KoreaDepartment of Radiology, Korea University Anam Hospital, Korea University College of Medicine, Seoul 136-705, Republic of KoreaDepartment of Internal Medicine, Hanil General Hospital, KEPCO Medical Foundation, Seoul 132-703, Republic of KoreaTuberculous destroyed lung (TDL) is diagnosed by a clear past history of tuberculosis with findings of parenchymal destruction verified by chest X-ray. Despite the resultant deterioration of lung function and quality of lives seen in TDL patients, the exact mechanism or characteristics of pulmonary function worsening have not been clearly studied. We investigated the feature of respiratory impairment of TDL patients, and studied whether extent of destroyed lung measured with chest CT has any correlation with routine lung function. To evaluate the degree of destruction, the Goddard classification scoring system was modified into a novel scoring system (destroyed lung score, (DLS)) with a score from 0 to 4. Twenty-five subjects were enrolled. TDL predominantly manifested as an obstructive pattern (64%, 16/25). Median value of DLS of the entire lung was 2.6 (1.7–3.9). Absolute values of FEV1 and FVC were both negatively associated with DLS (r=-0.78, P=0.001, and r=-0.61, P=0.021). Percentage of predicted value of FEV1 and FVC were also negatively associated with DLS (r=-0.62, P=0.019, and r=-0.76, P=0.002). Our study shows that lung function of TDL patients were notably correlated with the extent of destroyed lung measured with chest CT scan.http://dx.doi.org/10.1100/2012/835031 |
| spellingShingle | Eun Joo Lee Sang Yeub Lee Kwang Ho In Se Hwa Yoo Eun Jeong Choi Yu Whan Oh Sanghoon Park Routine Pulmonary Function Test Can Estimate the Extent of Tuberculous Destroyed Lung The Scientific World Journal |
| title | Routine Pulmonary Function Test Can Estimate the Extent of Tuberculous Destroyed Lung |
| title_full | Routine Pulmonary Function Test Can Estimate the Extent of Tuberculous Destroyed Lung |
| title_fullStr | Routine Pulmonary Function Test Can Estimate the Extent of Tuberculous Destroyed Lung |
| title_full_unstemmed | Routine Pulmonary Function Test Can Estimate the Extent of Tuberculous Destroyed Lung |
| title_short | Routine Pulmonary Function Test Can Estimate the Extent of Tuberculous Destroyed Lung |
| title_sort | routine pulmonary function test can estimate the extent of tuberculous destroyed lung |
| url | http://dx.doi.org/10.1100/2012/835031 |
| work_keys_str_mv | AT eunjoolee routinepulmonaryfunctiontestcanestimatetheextentoftuberculousdestroyedlung AT sangyeublee routinepulmonaryfunctiontestcanestimatetheextentoftuberculousdestroyedlung AT kwanghoin routinepulmonaryfunctiontestcanestimatetheextentoftuberculousdestroyedlung AT sehwayoo routinepulmonaryfunctiontestcanestimatetheextentoftuberculousdestroyedlung AT eunjeongchoi routinepulmonaryfunctiontestcanestimatetheextentoftuberculousdestroyedlung AT yuwhanoh routinepulmonaryfunctiontestcanestimatetheextentoftuberculousdestroyedlung AT sanghoonpark routinepulmonaryfunctiontestcanestimatetheextentoftuberculousdestroyedlung |