Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth population
Objective Physical inactivity inChinese youth students particularly in senior high schools, who participate inthe National Higher Education Entrance Examination (NCEE) is very common. Inorder to explore the beneficial effects from physical exercise and education afterNCEE, we performed a Physicalexe...
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BMJ Publishing Group
2020-12-01
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| Series: | BMJ Open Sport & Exercise Medicine |
| Online Access: | https://bmjopensem.bmj.com/content/6/1/e000681.full |
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| author | Ting Zhang Hui Wang Chong Shen Juan Su Yuanrui Tian Haixu Hu Wanjian Gu Mengxia Li Harvest F Gu |
| author_facet | Ting Zhang Hui Wang Chong Shen Juan Su Yuanrui Tian Haixu Hu Wanjian Gu Mengxia Li Harvest F Gu |
| author_sort | Ting Zhang |
| collection | DOAJ |
| description | Objective Physical inactivity inChinese youth students particularly in senior high schools, who participate inthe National Higher Education Entrance Examination (NCEE) is very common. Inorder to explore the beneficial effects from physical exercise and education afterNCEE, we performed a Physicalexercise Intervention Program in the Youth (PiPy) to evaluate the interaction with PPARγ genetic variants on cardiovascular and metabolicparameters.Methods A total of 772 freshmen (males 610/females162) from high schools to university were recruited into the PiPy cohort, which was designedaccording to the National Student Health Standards in China. Anthropometric data were collected, whilephysical activities and body composition at the baseline of PiPy cohort weremeasured with SECAprotocols. Eighttagged single nucleotide polymorphisms (SNPs) in the PPARγ gene were genotyped with TaqMan allelicdiscrimination.Results After physical exercise intervention forthree months, in parallel with increased physical activities, BMI and skeletalmuscle content in all subjects was enhanced, while heart rate and bloodpressures were decreased. Furthermore, SNPs in 5’-UTR of the PPARγ gene, including rs2920502,rs9817428 and rs2972164, were found to be associated with the changes of BMI.Body weight in the subjects with BMI <18.5and 18.5-23.9 kg/m2 were increased,while the obese subjects (BMI ≥24.0 kg/m2) decreased.Conclusion The present study for the first timedemonstrated that the PiPy could improve cardio-metabolic parameters such asheart rate, blood pressures and BMI for Chinese youth students after NCEE, inwhich the genetic interactive effects of PPARγ should be included into obesityintervention. |
| format | Article |
| id | doaj-art-994584768c4f4a1798b65b337fd2f3cc |
| institution | OA Journals |
| issn | 2055-7647 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Sport & Exercise Medicine |
| spelling | doaj-art-994584768c4f4a1798b65b337fd2f3cc2025-08-20T01:47:33ZengBMJ Publishing GroupBMJ Open Sport & Exercise Medicine2055-76472020-12-016110.1136/bmjsem-2019-000681Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth populationTing Zhang0Hui Wang1Chong Shen2Juan Su3Yuanrui Tian4Haixu Hu5Wanjian Gu6Mengxia Li7Harvest F Gu82 Central Laboratory of Infection and Immunity, Capital Institute of Pediatrics, Beijing, ChinaDepartment of Nursing, Beijing Tiantan Hospital, Capital Medical University, Beijing, China2 Department of Epidemiology, Nanjing Medical University, Nanjing, China1 Department of Dermatology | Hunan Engineering Research Center of Skin Health and Disease | Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, ChinaDepartment of Physical Education, Nanjing University of Aeronautics and Astronautics, Nanjing, ChinaDepartment of Clinical Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, ChinaCenter for Pathophysiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, ChinaObjective Physical inactivity inChinese youth students particularly in senior high schools, who participate inthe National Higher Education Entrance Examination (NCEE) is very common. Inorder to explore the beneficial effects from physical exercise and education afterNCEE, we performed a Physicalexercise Intervention Program in the Youth (PiPy) to evaluate the interaction with PPARγ genetic variants on cardiovascular and metabolicparameters.Methods A total of 772 freshmen (males 610/females162) from high schools to university were recruited into the PiPy cohort, which was designedaccording to the National Student Health Standards in China. Anthropometric data were collected, whilephysical activities and body composition at the baseline of PiPy cohort weremeasured with SECAprotocols. Eighttagged single nucleotide polymorphisms (SNPs) in the PPARγ gene were genotyped with TaqMan allelicdiscrimination.Results After physical exercise intervention forthree months, in parallel with increased physical activities, BMI and skeletalmuscle content in all subjects was enhanced, while heart rate and bloodpressures were decreased. Furthermore, SNPs in 5’-UTR of the PPARγ gene, including rs2920502,rs9817428 and rs2972164, were found to be associated with the changes of BMI.Body weight in the subjects with BMI <18.5and 18.5-23.9 kg/m2 were increased,while the obese subjects (BMI ≥24.0 kg/m2) decreased.Conclusion The present study for the first timedemonstrated that the PiPy could improve cardio-metabolic parameters such asheart rate, blood pressures and BMI for Chinese youth students after NCEE, inwhich the genetic interactive effects of PPARγ should be included into obesityintervention.https://bmjopensem.bmj.com/content/6/1/e000681.full |
| spellingShingle | Ting Zhang Hui Wang Chong Shen Juan Su Yuanrui Tian Haixu Hu Wanjian Gu Mengxia Li Harvest F Gu Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth population BMJ Open Sport & Exercise Medicine |
| title | Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth population |
| title_full | Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth population |
| title_fullStr | Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth population |
| title_full_unstemmed | Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth population |
| title_short | Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth population |
| title_sort | impact of physical exercise intervention and pparγ genetic polymorphisms on cardio metabolic parameters among a chinese youth population |
| url | https://bmjopensem.bmj.com/content/6/1/e000681.full |
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