Convergence and divergence of B cell responses in two HIV-1 Env immunizations in Rhesus macaques

Convergence and divergence of B cell responses in two HIV-1 Env immunizations in Rhesus macaques

Abstract Background Sequential multivalent immunizations are used to counter diversity in rapidly mutating viruses. Here, we evaluated the effect of HIV-1 immunogen formats on the binding profile of memory B-cells elicited in two independent Rhesus macaque trials. Methods In one trial, female Rhesus...

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Main Authors: Jenna M. DeLuca, Maria Blasi, Taylor J. McGee, Shalini Jha, Xiaoying Shen, Shuqin Gu, Justin Pollara, Melissa Kerkau, Mansi Purwar, Diane G. Carnathan, Donatella Negri, Andrea Cara, Kurt Wollenberg, Kevin Wiehe, Kevin O. Saunders, Shan Lu, Guido Silvestri, David B. Weiner, Mary E. Klotman, Guido Ferrari, M. Anthony Moody, Mattia Bonsignori
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00899-3
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