Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilms
Abstract Historical processes in community assembly, such as species arrival order, influence interactions, causing priority effects. Candida albicans and Pseudomonas aeruginosa often co-occur in biofilm-based infections of the skin, lungs, and medical devices. Their predominantly antagonistic relat...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07609-8 |
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| author | Betsy V. Arévalo-Jaimes Joana Admella Eduard Torrents |
| author_facet | Betsy V. Arévalo-Jaimes Joana Admella Eduard Torrents |
| author_sort | Betsy V. Arévalo-Jaimes |
| collection | DOAJ |
| description | Abstract Historical processes in community assembly, such as species arrival order, influence interactions, causing priority effects. Candida albicans and Pseudomonas aeruginosa often co-occur in biofilm-based infections of the skin, lungs, and medical devices. Their predominantly antagonistic relationship involves complex physical and chemical interactions. However, the presence and implications of priority effects among these microorganisms remain largely unexplored. Here, we investigate the presence and impact of priority effect in dual-species biofilms using clinical isolates. By varying inoculation order, we observe significant changes in biofilm composition, structure, virulence, and antimicrobial susceptibility. The first colonizer has an advantage for surface colonization. Consecutive colonization increases biofilm virulence and negates C. albicans’ protective effect on P. aeruginosa PAET1 against meropenem treatment. Finally, we propose N-acetylcysteine as an adjuvant for treating C. albicans and P. aeruginosa interkingdom infections, working independently of priority effects. |
| format | Article |
| id | doaj-art-9930366e035d4873b390f1d6a492429d |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-9930366e035d4873b390f1d6a492429d2025-02-09T12:50:26ZengNature PortfolioCommunications Biology2399-36422025-02-018111010.1038/s42003-025-07609-8Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilmsBetsy V. Arévalo-Jaimes0Joana Admella1Eduard Torrents2Bacterial infections and antimicrobial therapies group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and TechnologyBacterial infections and antimicrobial therapies group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and TechnologyBacterial infections and antimicrobial therapies group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and TechnologyAbstract Historical processes in community assembly, such as species arrival order, influence interactions, causing priority effects. Candida albicans and Pseudomonas aeruginosa often co-occur in biofilm-based infections of the skin, lungs, and medical devices. Their predominantly antagonistic relationship involves complex physical and chemical interactions. However, the presence and implications of priority effects among these microorganisms remain largely unexplored. Here, we investigate the presence and impact of priority effect in dual-species biofilms using clinical isolates. By varying inoculation order, we observe significant changes in biofilm composition, structure, virulence, and antimicrobial susceptibility. The first colonizer has an advantage for surface colonization. Consecutive colonization increases biofilm virulence and negates C. albicans’ protective effect on P. aeruginosa PAET1 against meropenem treatment. Finally, we propose N-acetylcysteine as an adjuvant for treating C. albicans and P. aeruginosa interkingdom infections, working independently of priority effects.https://doi.org/10.1038/s42003-025-07609-8 |
| spellingShingle | Betsy V. Arévalo-Jaimes Joana Admella Eduard Torrents Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilms Communications Biology |
| title | Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilms |
| title_full | Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilms |
| title_fullStr | Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilms |
| title_full_unstemmed | Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilms |
| title_short | Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilms |
| title_sort | who arrived first priority effects on candida albicans and pseudomonas aeruginosa dual biofilms |
| url | https://doi.org/10.1038/s42003-025-07609-8 |
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