Targeting TCMR-associated cytokine genes for drug screening identifies PPARγ agonists as novel immunomodulatory agents in transplantation

Targeting TCMR-associated cytokine genes for drug screening identifies PPARγ agonists as novel immunomodulatory agents in transplantation

ObjectiveT cell-mediated rejection (TCMR) remains a significant challenge in organ transplantation. This study aimed to define a TCMR-associated cytokine gene set and identify drugs to prevent TCMR through drug repurposing.MethodsGene expression profiles from kidney, heart, and lung transplant biops...

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Bibliographic Details
Main Authors: Lu Hu, Xiaohan Zhang, Weiqi Zhang, Shuai Jin, Jie Zhao, Jianming Zheng, Wenli Song, Zhongyang Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
T-cell-mediated rejection
organ transplantation
cytokine genes
predictive model
drug repurposing
PPARγ agonists
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1539645/full
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