Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture
Emerging evidence demonstrates that microRNAs, as important endogenous posttranscriptional regulators, are essential for bone remodeling and regeneration. Undoubtedly, microRNA-based gene therapies show great potential to become novel approaches against bone-related diseases, including osteoporosis...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/6782653 |
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| _version_ | 1832567114985111552 |
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| author | Xi Sun Qi Guo Wenhua Wei Stephen Robertson Ying Yuan Xianghang Luo |
| author_facet | Xi Sun Qi Guo Wenhua Wei Stephen Robertson Ying Yuan Xianghang Luo |
| author_sort | Xi Sun |
| collection | DOAJ |
| description | Emerging evidence demonstrates that microRNAs, as important endogenous posttranscriptional regulators, are essential for bone remodeling and regeneration. Undoubtedly, microRNA-based gene therapies show great potential to become novel approaches against bone-related diseases, including osteoporosis and associated fractures. The major obstacles for continued advancement of microRNA-based therapies in clinical application include their poor in vivo stability, nonspecific biodistribution, and unwanted side effects. Appropriate chemical modifications and delivery vectors, which improve the biological performance and potency of microRNA-based drugs, hold the key to translating miRNA technologies into clinical practice. Thus, this review summarizes the current attempts and existing deficiencies of chemical modifications and delivery systems applied in microRNA-based therapies for osteoporosis and osteoporotic fractures to inform further explorations. |
| format | Article |
| id | doaj-art-9927d5255a1144fa808397bfe028efcc |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-9927d5255a1144fa808397bfe028efcc2025-02-03T01:02:16ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/67826536782653Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic FractureXi Sun0Qi Guo1Wenhua Wei2Stephen Robertson3Ying Yuan4Xianghang Luo5Department of Endocrinology, The Third Xiangya Hospital of Central South University, 138# Tongzipo Road, Changsha, Hunan 410007, ChinaDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, 87# Xiangya Road, Changsha, Hunan 410008, ChinaDepartment of Women’s and Children’s Health, Dunedin School of Medicine, University of Otago, Dunedin 9016, New ZealandDepartment of Women’s and Children’s Health, Dunedin School of Medicine, University of Otago, Dunedin 9016, New ZealandDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, 87# Xiangya Road, Changsha, Hunan 410008, ChinaDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, 87# Xiangya Road, Changsha, Hunan 410008, ChinaEmerging evidence demonstrates that microRNAs, as important endogenous posttranscriptional regulators, are essential for bone remodeling and regeneration. Undoubtedly, microRNA-based gene therapies show great potential to become novel approaches against bone-related diseases, including osteoporosis and associated fractures. The major obstacles for continued advancement of microRNA-based therapies in clinical application include their poor in vivo stability, nonspecific biodistribution, and unwanted side effects. Appropriate chemical modifications and delivery vectors, which improve the biological performance and potency of microRNA-based drugs, hold the key to translating miRNA technologies into clinical practice. Thus, this review summarizes the current attempts and existing deficiencies of chemical modifications and delivery systems applied in microRNA-based therapies for osteoporosis and osteoporotic fractures to inform further explorations.http://dx.doi.org/10.1155/2019/6782653 |
| spellingShingle | Xi Sun Qi Guo Wenhua Wei Stephen Robertson Ying Yuan Xianghang Luo Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture International Journal of Endocrinology |
| title | Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture |
| title_full | Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture |
| title_fullStr | Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture |
| title_full_unstemmed | Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture |
| title_short | Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture |
| title_sort | current progress on microrna based gene delivery in the treatment of osteoporosis and osteoporotic fracture |
| url | http://dx.doi.org/10.1155/2019/6782653 |
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