Molecular Epidemiology of Travel-Associated and Locally Acquired Dengue Virus Infections in Catalonia, Spain, 2019
Dengue virus (DENV) is the most important arbovirus worldwide. In 2019, a significant increase in dengue cases was reported worldwide, resulting in a peak of imported cases in some European countries such as Spain. We aimed to describe travel-associated and locally acquired DENV strains detected in...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/17/5/621 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850125918299750400 |
|---|---|
| author | Jéssica Navero-Castillejos Adrián Sánchez-Montalvá Elena Sulleiro Aroa Silgado Tomás Montalvo Laura Barahona Núria Busquets José Muñoz Daniel Camprubí-Ferrer Manuel Valdivia Ana Martínez Maria Assumpció Bou-Monclús Itziar Martínez-Calleja Mireia Jané Cristina Rius Hernán Vargas-Leguas Beatriz Escudero-Pérez Rosa Albarracín Alexander Navarro Mireia Navarro Josep Barrachina Miguel J. Martínez |
| author_facet | Jéssica Navero-Castillejos Adrián Sánchez-Montalvá Elena Sulleiro Aroa Silgado Tomás Montalvo Laura Barahona Núria Busquets José Muñoz Daniel Camprubí-Ferrer Manuel Valdivia Ana Martínez Maria Assumpció Bou-Monclús Itziar Martínez-Calleja Mireia Jané Cristina Rius Hernán Vargas-Leguas Beatriz Escudero-Pérez Rosa Albarracín Alexander Navarro Mireia Navarro Josep Barrachina Miguel J. Martínez |
| author_sort | Jéssica Navero-Castillejos |
| collection | DOAJ |
| description | Dengue virus (DENV) is the most important arbovirus worldwide. In 2019, a significant increase in dengue cases was reported worldwide, resulting in a peak of imported cases in some European countries such as Spain. We aimed to describe travel-associated and locally acquired DENV strains detected in 2019 in the Catalonia region (northeastern Spain), a hotspot for dengue introduction in Europe. Through sequencing and phylogenetic analysis of the envelope gene, 75 imported viremic cases and two local strains were described. Autochthonous transmission events included an infection of a local mosquito with an imported dengue strain and a locally acquired human dengue infection from a locally infected mosquito. Overall, all four DENV serotypes and up to 10 different genotypes were detected. Phylogenetic analysis revealed transcontinental circulations associated with DENV-1 and DENV-2 and the presence of DENV-4 genotype I in Indonesia, where few cases had been previously described. A molecular study of the autochthonous events determined that local <i>Ae. albopictus</i> mosquitoes were infected by an African DENV-1 genotype V strain, while the locally acquired human case was caused by a DENV-3 genotype I of Asian origin. These findings underline the wide variability of imported strains and the high risk of DENV introduction into this territory, emphasizing the importance and usefulness of molecular characterization and phylogenetics for both local and global surveillance of the disease. |
| format | Article |
| id | doaj-art-99275dc0b2b94575906826afb19df8df |
| institution | OA Journals |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-99275dc0b2b94575906826afb19df8df2025-08-20T02:34:02ZengMDPI AGViruses1999-49152025-04-0117562110.3390/v17050621Molecular Epidemiology of Travel-Associated and Locally Acquired Dengue Virus Infections in Catalonia, Spain, 2019Jéssica Navero-Castillejos0Adrián Sánchez-Montalvá1Elena Sulleiro2Aroa Silgado3Tomás Montalvo4Laura Barahona5Núria Busquets6José Muñoz7Daniel Camprubí-Ferrer8Manuel Valdivia9Ana Martínez10Maria Assumpció Bou-Monclús11Itziar Martínez-Calleja12Mireia Jané13Cristina Rius14Hernán Vargas-Leguas15Beatriz Escudero-Pérez16Rosa Albarracín17Alexander Navarro18Mireia Navarro19Josep Barrachina20Miguel J. Martínez21Department of Clinical Microbiology, Hospital Clínic de Barcelona, 08036 Barcelona, SpainInfectious Diseases Department, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, PROSICS, 08035 Barcelona, SpainInfectious Diseases Department, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, PROSICS, 08035 Barcelona, SpainInfectious Diseases Department, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, PROSICS, 08035 Barcelona, SpainUrban Pest Surveillance and Control Service, Public Health Agency of Barcelona, 08023 Barcelona, SpainUrban Pest Surveillance and Control Service, Public Health Agency of Barcelona, 08023 Barcelona, SpainIRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Universitat Autònoma de Barcelona, 08193 Bellaterra, SpainBarcelona Institute for Global Health (ISGlobal), Hospital Clínic de Barcelona, Universitat de Barcelona, 08036 Barcelona, SpainBarcelona Institute for Global Health (ISGlobal), Hospital Clínic de Barcelona, Universitat de Barcelona, 08036 Barcelona, SpainPublic Health Agency of Catalonia, Generalitat of Catalonia, 08005 Barcelona, SpainPublic Health Agency of Catalonia, Generalitat of Catalonia, 08005 Barcelona, SpainPublic Health Agency of Catalonia, Generalitat of Catalonia, 08005 Barcelona, SpainPublic Health Agency of Catalonia, Generalitat of Catalonia, 08005 Barcelona, SpainPublic Health Agency of Catalonia, Generalitat of Catalonia, 08005 Barcelona, SpainCIBER Epidemiologia y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, SpainEpidemiology Service, Public Health Agency of Barcelona, 08023 Barcelona, SpainDepartment of Clinical Microbiology, Hospital Clínic de Barcelona, 08036 Barcelona, SpainDepartment of Clinical Microbiology, Hospital Clínic de Barcelona, 08036 Barcelona, SpainDepartment of Clinical Microbiology, Hospital Clínic de Barcelona, 08036 Barcelona, SpainDepartment of Clinical Microbiology, Hospital Clínic de Barcelona, 08036 Barcelona, SpainDepartment of Clinical Microbiology, Hospital Clínic de Barcelona, 08036 Barcelona, SpainDepartment of Clinical Microbiology, Hospital Clínic de Barcelona, 08036 Barcelona, SpainDengue virus (DENV) is the most important arbovirus worldwide. In 2019, a significant increase in dengue cases was reported worldwide, resulting in a peak of imported cases in some European countries such as Spain. We aimed to describe travel-associated and locally acquired DENV strains detected in 2019 in the Catalonia region (northeastern Spain), a hotspot for dengue introduction in Europe. Through sequencing and phylogenetic analysis of the envelope gene, 75 imported viremic cases and two local strains were described. Autochthonous transmission events included an infection of a local mosquito with an imported dengue strain and a locally acquired human dengue infection from a locally infected mosquito. Overall, all four DENV serotypes and up to 10 different genotypes were detected. Phylogenetic analysis revealed transcontinental circulations associated with DENV-1 and DENV-2 and the presence of DENV-4 genotype I in Indonesia, where few cases had been previously described. A molecular study of the autochthonous events determined that local <i>Ae. albopictus</i> mosquitoes were infected by an African DENV-1 genotype V strain, while the locally acquired human case was caused by a DENV-3 genotype I of Asian origin. These findings underline the wide variability of imported strains and the high risk of DENV introduction into this territory, emphasizing the importance and usefulness of molecular characterization and phylogenetics for both local and global surveillance of the disease.https://www.mdpi.com/1999-4915/17/5/621dengueautochthonous transmissionsurveillance<i>Aedes albopictus</i>molecular epidemiologyphylogenetic analysis |
| spellingShingle | Jéssica Navero-Castillejos Adrián Sánchez-Montalvá Elena Sulleiro Aroa Silgado Tomás Montalvo Laura Barahona Núria Busquets José Muñoz Daniel Camprubí-Ferrer Manuel Valdivia Ana Martínez Maria Assumpció Bou-Monclús Itziar Martínez-Calleja Mireia Jané Cristina Rius Hernán Vargas-Leguas Beatriz Escudero-Pérez Rosa Albarracín Alexander Navarro Mireia Navarro Josep Barrachina Miguel J. Martínez Molecular Epidemiology of Travel-Associated and Locally Acquired Dengue Virus Infections in Catalonia, Spain, 2019 Viruses dengue autochthonous transmission surveillance <i>Aedes albopictus</i> molecular epidemiology phylogenetic analysis |
| title | Molecular Epidemiology of Travel-Associated and Locally Acquired Dengue Virus Infections in Catalonia, Spain, 2019 |
| title_full | Molecular Epidemiology of Travel-Associated and Locally Acquired Dengue Virus Infections in Catalonia, Spain, 2019 |
| title_fullStr | Molecular Epidemiology of Travel-Associated and Locally Acquired Dengue Virus Infections in Catalonia, Spain, 2019 |
| title_full_unstemmed | Molecular Epidemiology of Travel-Associated and Locally Acquired Dengue Virus Infections in Catalonia, Spain, 2019 |
| title_short | Molecular Epidemiology of Travel-Associated and Locally Acquired Dengue Virus Infections in Catalonia, Spain, 2019 |
| title_sort | molecular epidemiology of travel associated and locally acquired dengue virus infections in catalonia spain 2019 |
| topic | dengue autochthonous transmission surveillance <i>Aedes albopictus</i> molecular epidemiology phylogenetic analysis |
| url | https://www.mdpi.com/1999-4915/17/5/621 |
| work_keys_str_mv | AT jessicanaverocastillejos molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT adriansanchezmontalva molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT elenasulleiro molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT aroasilgado molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT tomasmontalvo molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT laurabarahona molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT nuriabusquets molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT josemunoz molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT danielcamprubiferrer molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT manuelvaldivia molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT anamartinez molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT mariaassumpcioboumonclus molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT itziarmartinezcalleja molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT mireiajane molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT cristinarius molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT hernanvargasleguas molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT beatrizescuderoperez molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT rosaalbarracin molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT alexandernavarro molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT mireianavarro molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT josepbarrachina molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 AT migueljmartinez molecularepidemiologyoftravelassociatedandlocallyacquireddenguevirusinfectionsincataloniaspain2019 |