Association between dietary selenium intake and depression in patients with or without stroke: a cross-sectional study
BackgroundDepression and stroke are life-threatening diseases with high incidence, research suggests an interaction between dietary selenium and depression and stroke. However, the relationship between dietary selenium and depression has not been adequately studied. Therefore, the purpose of this st...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1493603/full |
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| author | Shuang Wu Zhimin Mei Jin Gao Songshan Chai |
| author_facet | Shuang Wu Zhimin Mei Jin Gao Songshan Chai |
| author_sort | Shuang Wu |
| collection | DOAJ |
| description | BackgroundDepression and stroke are life-threatening diseases with high incidence, research suggests an interaction between dietary selenium and depression and stroke. However, the relationship between dietary selenium and depression has not been adequately studied. Therefore, the purpose of this study was to assess the association between dietary selenium and depression among individuals with or without stroke.MethodsA cross-sectional study was performed using the 2011–2018 National Health and Nutrition Examination Survey dataset (N = 15,018). Logistic regression, interaction effect analysis, and restricted cubic spline analysis were used for statistical analyses.ResultsThe association between dietary selenium intake and prevalence depression differed between the non-stroke and stroke groups. Furthermore, when dietary selenium was converted into a categorical variable, there was evidence of an interaction between stroke status and selenium intake on decreasing the prevalence of depression (p = 0.007). What’s more, the dose–response association between dietary selenium intake and depression indicated various patterns between participants with and without stroke.LimitationsA cross-sectional study cannot be used to infer causal relationships.ConclusionA non-linear relationship was observed in individuals without stroke, characterized by an apparent threshold of approximately 128.4 mcg/d. In contrast, no association was observed between dietary selenium intake and depression in participants with stroke. Further research is necessary to validate the present findings. |
| format | Article |
| id | doaj-art-9923f71cb1ab4f8b8d9b050ca7e5af12 |
| institution | DOAJ |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-9923f71cb1ab4f8b8d9b050ca7e5af122025-08-20T03:07:47ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-06-011210.3389/fnut.2025.14936031493603Association between dietary selenium intake and depression in patients with or without stroke: a cross-sectional studyShuang Wu0Zhimin Mei1Jin Gao2Songshan Chai3The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan, ChinaGeneral Hospital of the Yangtze River Shipping, Wuhan Brain Hospital, Wuhan, ChinaZhongnan Hospital of Wuhan University, Wuhan, ChinaZhongnan Hospital of Wuhan University, Wuhan, ChinaBackgroundDepression and stroke are life-threatening diseases with high incidence, research suggests an interaction between dietary selenium and depression and stroke. However, the relationship between dietary selenium and depression has not been adequately studied. Therefore, the purpose of this study was to assess the association between dietary selenium and depression among individuals with or without stroke.MethodsA cross-sectional study was performed using the 2011–2018 National Health and Nutrition Examination Survey dataset (N = 15,018). Logistic regression, interaction effect analysis, and restricted cubic spline analysis were used for statistical analyses.ResultsThe association between dietary selenium intake and prevalence depression differed between the non-stroke and stroke groups. Furthermore, when dietary selenium was converted into a categorical variable, there was evidence of an interaction between stroke status and selenium intake on decreasing the prevalence of depression (p = 0.007). What’s more, the dose–response association between dietary selenium intake and depression indicated various patterns between participants with and without stroke.LimitationsA cross-sectional study cannot be used to infer causal relationships.ConclusionA non-linear relationship was observed in individuals without stroke, characterized by an apparent threshold of approximately 128.4 mcg/d. In contrast, no association was observed between dietary selenium intake and depression in participants with stroke. Further research is necessary to validate the present findings.https://www.frontiersin.org/articles/10.3389/fnut.2025.1493603/fulldietaryseleniumdepressionNational Health and Nutrition Examinationstroke |
| spellingShingle | Shuang Wu Zhimin Mei Jin Gao Songshan Chai Association between dietary selenium intake and depression in patients with or without stroke: a cross-sectional study Frontiers in Nutrition dietary selenium depression National Health and Nutrition Examination stroke |
| title | Association between dietary selenium intake and depression in patients with or without stroke: a cross-sectional study |
| title_full | Association between dietary selenium intake and depression in patients with or without stroke: a cross-sectional study |
| title_fullStr | Association between dietary selenium intake and depression in patients with or without stroke: a cross-sectional study |
| title_full_unstemmed | Association between dietary selenium intake and depression in patients with or without stroke: a cross-sectional study |
| title_short | Association between dietary selenium intake and depression in patients with or without stroke: a cross-sectional study |
| title_sort | association between dietary selenium intake and depression in patients with or without stroke a cross sectional study |
| topic | dietary selenium depression National Health and Nutrition Examination stroke |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1493603/full |
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