The level of inflammatory markers in patients with myocardial infarction after percutaneous coronary intervention
Cardiovascular diseases are among the most widespread diseases in the world that affect all ages and sometimes can lead to death. Atherosclerosis, coronary syndrome and myocardial infarction are usually associated with artery occlusion and require percutaneous coronary intervention (PCI) as a non-su...
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2024-08-01
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| Series: | The Ukrainian Biochemical Journal |
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| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2024/07/Abd-Alwahab_96_4.pdf |
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| author | Hadeel S. Abd-Alwahab Bayadir Abdul Hussein Mahmeed Nesreen Ahmed Nasser Osama A. Mohsein |
| author_facet | Hadeel S. Abd-Alwahab Bayadir Abdul Hussein Mahmeed Nesreen Ahmed Nasser Osama A. Mohsein |
| author_sort | Hadeel S. Abd-Alwahab |
| collection | DOAJ |
| description | Cardiovascular diseases are among the most widespread diseases in the world that affect all ages and sometimes can lead to death. Atherosclerosis, coronary syndrome and myocardial infarction are usually associated with artery occlusion and require percutaneous coronary intervention (PCI) as a non-surgical procedure to restore blood flow to the heart. Inflammatory biomarkers, especially interleukins and cardiac biomarkers, have an important role in diagnosing the state of patients with heart damage. The goal of the study was to estimate the serum levels of interleukins and cardiac biomarkers after PCI to reduce the risk of acute coronary syndrome. The study included 100 persons between the ages of 40 and 69 diagnosed with acute coronary syndrome who had successful PCI and a control group consisting of 50 healthy participants of the same age. The levels of interleukins, сreatine kinase MB and myoglobin were measured using an enzyme-linked immunosorbent assay. Troponin and D-dimer levels were measured using immunoassay. It was found that patients before PCI had significantly higher levels of IL-1β, IL-6, IL-8, cardiac troponin I, D-dimer, creatine kinase-MB and myoglobin compared to the control group. One day after PCI, the levels of IL -6, IL-8, cardiac troponin I and D-dimer remained elevated. One week after PCI, the levels of IL-1β, IL-6, IL-8, CK-MB and myoglobin did not show significant differences compared to the control group, while the levels of cardiac troponin I and D-dimer remained higher. Results obtained indicate that in patients after PCI, the levels of interleukins decreased, indicating the reduction of inflammatory processes, but cardiac damage persists to a certain degree, even a week after PCI. |
| format | Article |
| id | doaj-art-99173f386bb44082aa96d54048c5ff97 |
| institution | OA Journals |
| issn | 2409-4943 2413-5003 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj-art-99173f386bb44082aa96d54048c5ff972025-08-20T01:50:38ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032024-08-01964445410.15407/ubj96.04.044The level of inflammatory markers in patients with myocardial infarction after percutaneous coronary interventionHadeel S. Abd-Alwahab0https://orcid.org/0000-0003-3463-213XBayadir Abdul Hussein Mahmeed1Nesreen Ahmed Nasser2https://orcid.org/0000-0003-3047-9967Osama A. Mohsein3https://orcid.org/0009-0004-5628-2382College of Medicine, Al-Nahrain University, Baghdad, IraqCollege of Medicine, Al-Nahrain University, Baghdad, IraqCollege of Medicine, Al-Nahrain University, Baghdad, IraqMain Laboratory Unit, Al Habbobi Teaching Hospital, Thi-Qar Health Directorate, Thi-Qar, Iraq; Department of Medical Laboratory Techniques, Mazaya University College, Thi-Qar, IraqCardiovascular diseases are among the most widespread diseases in the world that affect all ages and sometimes can lead to death. Atherosclerosis, coronary syndrome and myocardial infarction are usually associated with artery occlusion and require percutaneous coronary intervention (PCI) as a non-surgical procedure to restore blood flow to the heart. Inflammatory biomarkers, especially interleukins and cardiac biomarkers, have an important role in diagnosing the state of patients with heart damage. The goal of the study was to estimate the serum levels of interleukins and cardiac biomarkers after PCI to reduce the risk of acute coronary syndrome. The study included 100 persons between the ages of 40 and 69 diagnosed with acute coronary syndrome who had successful PCI and a control group consisting of 50 healthy participants of the same age. The levels of interleukins, сreatine kinase MB and myoglobin were measured using an enzyme-linked immunosorbent assay. Troponin and D-dimer levels were measured using immunoassay. It was found that patients before PCI had significantly higher levels of IL-1β, IL-6, IL-8, cardiac troponin I, D-dimer, creatine kinase-MB and myoglobin compared to the control group. One day after PCI, the levels of IL -6, IL-8, cardiac troponin I and D-dimer remained elevated. One week after PCI, the levels of IL-1β, IL-6, IL-8, CK-MB and myoglobin did not show significant differences compared to the control group, while the levels of cardiac troponin I and D-dimer remained higher. Results obtained indicate that in patients after PCI, the levels of interleukins decreased, indicating the reduction of inflammatory processes, but cardiac damage persists to a certain degree, even a week after PCI.http://ukrbiochemjournal.org/wp-content/uploads/2024/07/Abd-Alwahab_96_4.pdfcreatine kinase mbd-dimerinterleukinmyocardial infarctionmyoglobinpercutaneous coronary intervention |
| spellingShingle | Hadeel S. Abd-Alwahab Bayadir Abdul Hussein Mahmeed Nesreen Ahmed Nasser Osama A. Mohsein The level of inflammatory markers in patients with myocardial infarction after percutaneous coronary intervention The Ukrainian Biochemical Journal creatine kinase mb d-dimer interleukin myocardial infarction myoglobin percutaneous coronary intervention |
| title | The level of inflammatory markers in patients with myocardial infarction after percutaneous coronary intervention |
| title_full | The level of inflammatory markers in patients with myocardial infarction after percutaneous coronary intervention |
| title_fullStr | The level of inflammatory markers in patients with myocardial infarction after percutaneous coronary intervention |
| title_full_unstemmed | The level of inflammatory markers in patients with myocardial infarction after percutaneous coronary intervention |
| title_short | The level of inflammatory markers in patients with myocardial infarction after percutaneous coronary intervention |
| title_sort | level of inflammatory markers in patients with myocardial infarction after percutaneous coronary intervention |
| topic | creatine kinase mb d-dimer interleukin myocardial infarction myoglobin percutaneous coronary intervention |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2024/07/Abd-Alwahab_96_4.pdf |
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