Nose-to-brain drug delivery by HS15 micelles for brain targeting of insoluble drug

Nose-to-brain drug delivery by HS15 micelles for brain targeting of insoluble drug

Agomelatine (AGO) is an antidepressant with limited clinical application due to its low bioavailability caused by poor water solubility, severe hepatic degradation, and poor intracerebral distribution. Nanotechnology-based strategies constitute a powerful tool by utilizing drug solubility and target...

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Bibliographic Details
Main Authors: Wei Zhang, Long Wan, Meiqi Han, Wen Guo, Zhiqi Wang, Xinyue Zhang, Xuyang Liu, Jiahao Wang, Yuling Mao
Format: Article
Language:English
Published: Compuscript Ltd 2024-04-01
Series:Acta Materia Medica
Online Access:https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0051
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