Meibomian Gland Loss and Dysfunction in Mild versus Moderate-Severe Thyroid Eye Disease
Purpose: To compare meibomian gland (MG) loss and MG dysfunction (MGD) in patients with mild versus moderate-severe thyroid eye disease (TED). Methods: Consecutive patients with TED and no other causes of dry eye disease underwent meibography and meiboscore of each eyelid were graded as 0 (no MG los...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Journal of Current Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/joco.joco_176_23 |
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| author | Hossein Aghaei Fatemeh Zarastvand Parya Abdolalizadeh Nasser Karimi Acieh Es’haghi Jeremy D. Clark Christopher J. Compton Nicole L. West Mohsen Bahmani Kashkouli |
| author_facet | Hossein Aghaei Fatemeh Zarastvand Parya Abdolalizadeh Nasser Karimi Acieh Es’haghi Jeremy D. Clark Christopher J. Compton Nicole L. West Mohsen Bahmani Kashkouli |
| author_sort | Hossein Aghaei |
| collection | DOAJ |
| description | Purpose:
To compare meibomian gland (MG) loss and MG dysfunction (MGD) in patients with mild versus moderate-severe thyroid eye disease (TED).
Methods:
Consecutive patients with TED and no other causes of dry eye disease underwent meibography and meiboscore of each eyelid were graded as 0 (no MG loss), 1 (<33% loss), 2 (33%–66% loss), and 3 (>66% loss), with a total score of 0–6. MG expression score (0–3), eyelid margin signs of MGD, lipid layer thickness (LLT), ocular surface disease index (OSDI), tear secretion, noninvasive tear break-up time (NITBUT), and tear meniscus height (TMH) were also assessed by a masked observer.
Results:
Included were 21 eyes (21 patients) with mild and 19 eyes (19 patients) with moderate-severe TED. The two groups were not different except for a higher frequency of smoking (P < 0.01). Eyes with moderate-severe TED showed a higher upper eyelid meiboscore (P = 0.03), MG expression score (P < 0.01), and tear film osmolality (P = 0.02) as well as lower LLT (P = 0.03). Total meiboscore had a significantly positive correlation with OSDI (rs = 0.37) and tear film osmolality (rs = 0.50) as well as a negative correlation with NITBUT (rs = −0.55), TMH (rs = −0.44), and LLT (rs = −0.38). While older age, male gender, smoking, and longer duration of disease were significantly associated with the higher (≥3) meiboscore in univariate analysis, none remained significant in multivariate analysis.
Conclusion:
MG loss and MGD were significantly more severe in moderate-severe than mild TED. |
| format | Article |
| id | doaj-art-9911cee6702f4a5d8a3b001653c570b3 |
| institution | OA Journals |
| issn | 2452-2325 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Current Ophthalmology |
| spelling | doaj-art-9911cee6702f4a5d8a3b001653c570b32025-08-20T02:13:52ZengWolters Kluwer Medknow PublicationsJournal of Current Ophthalmology2452-23252024-04-0136214515110.4103/joco.joco_176_23Meibomian Gland Loss and Dysfunction in Mild versus Moderate-Severe Thyroid Eye DiseaseHossein AghaeiFatemeh ZarastvandParya AbdolalizadehNasser KarimiAcieh Es’haghiJeremy D. ClarkChristopher J. ComptonNicole L. WestMohsen Bahmani KashkouliPurpose: To compare meibomian gland (MG) loss and MG dysfunction (MGD) in patients with mild versus moderate-severe thyroid eye disease (TED). Methods: Consecutive patients with TED and no other causes of dry eye disease underwent meibography and meiboscore of each eyelid were graded as 0 (no MG loss), 1 (<33% loss), 2 (33%–66% loss), and 3 (>66% loss), with a total score of 0–6. MG expression score (0–3), eyelid margin signs of MGD, lipid layer thickness (LLT), ocular surface disease index (OSDI), tear secretion, noninvasive tear break-up time (NITBUT), and tear meniscus height (TMH) were also assessed by a masked observer. Results: Included were 21 eyes (21 patients) with mild and 19 eyes (19 patients) with moderate-severe TED. The two groups were not different except for a higher frequency of smoking (P < 0.01). Eyes with moderate-severe TED showed a higher upper eyelid meiboscore (P = 0.03), MG expression score (P < 0.01), and tear film osmolality (P = 0.02) as well as lower LLT (P = 0.03). Total meiboscore had a significantly positive correlation with OSDI (rs = 0.37) and tear film osmolality (rs = 0.50) as well as a negative correlation with NITBUT (rs = −0.55), TMH (rs = −0.44), and LLT (rs = −0.38). While older age, male gender, smoking, and longer duration of disease were significantly associated with the higher (≥3) meiboscore in univariate analysis, none remained significant in multivariate analysis. Conclusion: MG loss and MGD were significantly more severe in moderate-severe than mild TED.https://journals.lww.com/10.4103/joco.joco_176_23meibographymeibomian gland dysfunctionmeiboscoresmokingthyroid eye diseases |
| spellingShingle | Hossein Aghaei Fatemeh Zarastvand Parya Abdolalizadeh Nasser Karimi Acieh Es’haghi Jeremy D. Clark Christopher J. Compton Nicole L. West Mohsen Bahmani Kashkouli Meibomian Gland Loss and Dysfunction in Mild versus Moderate-Severe Thyroid Eye Disease Journal of Current Ophthalmology meibography meibomian gland dysfunction meiboscore smoking thyroid eye diseases |
| title | Meibomian Gland Loss and Dysfunction in Mild versus Moderate-Severe Thyroid Eye Disease |
| title_full | Meibomian Gland Loss and Dysfunction in Mild versus Moderate-Severe Thyroid Eye Disease |
| title_fullStr | Meibomian Gland Loss and Dysfunction in Mild versus Moderate-Severe Thyroid Eye Disease |
| title_full_unstemmed | Meibomian Gland Loss and Dysfunction in Mild versus Moderate-Severe Thyroid Eye Disease |
| title_short | Meibomian Gland Loss and Dysfunction in Mild versus Moderate-Severe Thyroid Eye Disease |
| title_sort | meibomian gland loss and dysfunction in mild versus moderate severe thyroid eye disease |
| topic | meibography meibomian gland dysfunction meiboscore smoking thyroid eye diseases |
| url | https://journals.lww.com/10.4103/joco.joco_176_23 |
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