Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Management of Atopic Dermatitis: A Scoping Review of Therapeutic Opportunities and Challenges
Maimonah Eissa Al-Masawa, Loai A Elfawy, Chiew Yong Ng, Min Hwei Ng, Jia Xian Law Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaCorrespondence: Jia Xian Law, Department of Tissue Engineering and Regenerative Med...
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Dove Medical Press
2025-03-01
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| Series: | International Journal of Nanomedicine |
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| author | Al-Masawa ME Elfawy LA Ng CY Ng MH Law JX |
| author_facet | Al-Masawa ME Elfawy LA Ng CY Ng MH Law JX |
| author_sort | Al-Masawa ME |
| collection | DOAJ |
| description | Maimonah Eissa Al-Masawa, Loai A Elfawy, Chiew Yong Ng, Min Hwei Ng, Jia Xian Law Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaCorrespondence: Jia Xian Law, Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia, Email lawjx@hctm.ukm.edu.myAbstract: Atopic dermatitis (AD) is a global concern marked by inflammation, skin barrier dysfunction, and immune dysregulation. Current treatments primarily address symptoms without offering a cure, underscoring the need for innovative therapeutic approaches. Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) have attracted attention for their potential in immunomodulation and tissue repair, similar to their parent cells. This review provides a comprehensive analysis of the current landscape of MSC-EV research for AD management. We identified 12 studies that met our predefined inclusion criteria. We thoroughly reviewed both human and animal studies, analyzing aspects such as the source, isolation, and characterization of MSC-EVs, as well as the animal and disease models, dosage strategies, efficacy, mechanisms, and adverse effects. While this review highlights the promising potential of MSC-EV therapy for AD, it also emphasizes significant challenges, including heterogeneity and insufficient reporting. Given that this research area is still in its early stages, addressing these uncertainties will require collaborative efforts among researchers, regulatory bodies, and international societies to advance the field and improve patient outcomes. Keywords: exosome, eczema, atopic eczema, mesenchymal stem cells, cell-free therapy |
| format | Article |
| id | doaj-art-99107735f82c4b469023c85e9fcdf1ae |
| institution | DOAJ |
| issn | 1178-2013 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj-art-99107735f82c4b469023c85e9fcdf1ae2025-08-20T03:15:57ZengDove Medical PressInternational Journal of Nanomedicine1178-20132025-03-01Volume 2026732693100794Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Management of Atopic Dermatitis: A Scoping Review of Therapeutic Opportunities and ChallengesAl-Masawa MEElfawy LANg CYNg MHLaw JXMaimonah Eissa Al-Masawa, Loai A Elfawy, Chiew Yong Ng, Min Hwei Ng, Jia Xian Law Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaCorrespondence: Jia Xian Law, Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia, Email lawjx@hctm.ukm.edu.myAbstract: Atopic dermatitis (AD) is a global concern marked by inflammation, skin barrier dysfunction, and immune dysregulation. Current treatments primarily address symptoms without offering a cure, underscoring the need for innovative therapeutic approaches. Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) have attracted attention for their potential in immunomodulation and tissue repair, similar to their parent cells. This review provides a comprehensive analysis of the current landscape of MSC-EV research for AD management. We identified 12 studies that met our predefined inclusion criteria. We thoroughly reviewed both human and animal studies, analyzing aspects such as the source, isolation, and characterization of MSC-EVs, as well as the animal and disease models, dosage strategies, efficacy, mechanisms, and adverse effects. While this review highlights the promising potential of MSC-EV therapy for AD, it also emphasizes significant challenges, including heterogeneity and insufficient reporting. Given that this research area is still in its early stages, addressing these uncertainties will require collaborative efforts among researchers, regulatory bodies, and international societies to advance the field and improve patient outcomes. Keywords: exosome, eczema, atopic eczema, mesenchymal stem cells, cell-free therapyhttps://www.dovepress.com/mesenchymal-stromal-cell-derived-extracellular-vesicles-in-the-managem-peer-reviewed-fulltext-article-IJNexosomeeczemaatopic eczemamesenchymal stem cellscell-free therapy |
| spellingShingle | Al-Masawa ME Elfawy LA Ng CY Ng MH Law JX Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Management of Atopic Dermatitis: A Scoping Review of Therapeutic Opportunities and Challenges International Journal of Nanomedicine exosome eczema atopic eczema mesenchymal stem cells cell-free therapy |
| title | Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Management of Atopic Dermatitis: A Scoping Review of Therapeutic Opportunities and Challenges |
| title_full | Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Management of Atopic Dermatitis: A Scoping Review of Therapeutic Opportunities and Challenges |
| title_fullStr | Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Management of Atopic Dermatitis: A Scoping Review of Therapeutic Opportunities and Challenges |
| title_full_unstemmed | Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Management of Atopic Dermatitis: A Scoping Review of Therapeutic Opportunities and Challenges |
| title_short | Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Management of Atopic Dermatitis: A Scoping Review of Therapeutic Opportunities and Challenges |
| title_sort | mesenchymal stromal cell derived extracellular vesicles in the management of atopic dermatitis a scoping review of therapeutic opportunities and challenges |
| topic | exosome eczema atopic eczema mesenchymal stem cells cell-free therapy |
| url | https://www.dovepress.com/mesenchymal-stromal-cell-derived-extracellular-vesicles-in-the-managem-peer-reviewed-fulltext-article-IJN |
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