Comparison of postoperative vascularization between collagen matrix duraplasty and conventional duraplasty after direct bypass surgery in Moyamoya disease: A single-institute retrospective cohort study
Background: Moyamoya disease (MMD) is characterized by the development of collateral circulation through the dura mater and overexpression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFBGF). Type 1 collagen promotes VEGF- and bFBGF-dependent neovascularization. T...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
|
| Series: | World Neurosurgery: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590139725000572 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850106339612688384 |
|---|---|
| author | Izumi Yamaguchi Yasuhisa Kanematsu Kenji Shimada Masaaki Korai Takeshi Miyamoto Shu Sogabe Manabu Ishihara Tatsuya Haboshi Yasushi Takagi |
| author_facet | Izumi Yamaguchi Yasuhisa Kanematsu Kenji Shimada Masaaki Korai Takeshi Miyamoto Shu Sogabe Manabu Ishihara Tatsuya Haboshi Yasushi Takagi |
| author_sort | Izumi Yamaguchi |
| collection | DOAJ |
| description | Background: Moyamoya disease (MMD) is characterized by the development of collateral circulation through the dura mater and overexpression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFBGF). Type 1 collagen promotes VEGF- and bFBGF-dependent neovascularization. The usefulness of collagen matrix duraplasty has not been investigated in MMD, particularly regarding vascularization. The present retrospective study aimed to assess whether collagen matrix duraplasty enhances the postoperative vascularization in adult-onset MMD. Methods: Twenty-six patients (40 bypasses) who underwent direct bypass surgery for adult-onset MMD were included. The patients were categorized into a collagen matrix group (CMG; n = 17 [25 bypasses]) and a control group (CG; n = 9 [15 bypasses]). We compared postoperative vascularization with cerebral angiography, single-photon emission computed tomography (SPECT), and stroke-free survival. Results: The direct bypass was patent in 92 % of CMG and 86.7 % of CG, with no significant difference (p = 0.623). Middle meningeal artery blush was observed in 76 % of CMG and 80 % of CG, indicating similar development (p > 0.99). Matsushima angiographic grade was comparable between groups (good: CMG 20 %, CG 6.7 %; fair: CMG 72 %, CG 80 %; poor: CMG 8 %, CG 13.3 %), with no significant differences. The median relative cerebral blood flow significantly increased postoperatively in CMG (preoperative 0.85, postoperative 0.94; p = 0.009) but not in CG (preoperative 0.93, postoperative 0.94; p = 0.455). The two-year stroke-free survival based on duraplasty showed no significant difference (p = 0.726) between groups. Conclusions: Collagen matrix duraplasty does not enhance the postoperative vascularization status after direct bypass surgery in adult-onset MMD in the short term. |
| format | Article |
| id | doaj-art-990a52eccc6f4a90acf3bf4a76eecad7 |
| institution | OA Journals |
| issn | 2590-1397 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Neurosurgery: X |
| spelling | doaj-art-990a52eccc6f4a90acf3bf4a76eecad72025-08-20T02:38:51ZengElsevierWorld Neurosurgery: X2590-13972025-07-012710048310.1016/j.wnsx.2025.100483Comparison of postoperative vascularization between collagen matrix duraplasty and conventional duraplasty after direct bypass surgery in Moyamoya disease: A single-institute retrospective cohort studyIzumi Yamaguchi0Yasuhisa Kanematsu1Kenji Shimada2Masaaki Korai3Takeshi Miyamoto4Shu Sogabe5Manabu Ishihara6Tatsuya Haboshi7Yasushi Takagi8Corresponding author. Department of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, Japan.; Department of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, JapanDepartment of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, JapanDepartment of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, JapanDepartment of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, JapanDepartment of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, JapanDepartment of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, JapanDepartment of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, JapanDepartment of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, JapanDepartment of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, JapanBackground: Moyamoya disease (MMD) is characterized by the development of collateral circulation through the dura mater and overexpression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFBGF). Type 1 collagen promotes VEGF- and bFBGF-dependent neovascularization. The usefulness of collagen matrix duraplasty has not been investigated in MMD, particularly regarding vascularization. The present retrospective study aimed to assess whether collagen matrix duraplasty enhances the postoperative vascularization in adult-onset MMD. Methods: Twenty-six patients (40 bypasses) who underwent direct bypass surgery for adult-onset MMD were included. The patients were categorized into a collagen matrix group (CMG; n = 17 [25 bypasses]) and a control group (CG; n = 9 [15 bypasses]). We compared postoperative vascularization with cerebral angiography, single-photon emission computed tomography (SPECT), and stroke-free survival. Results: The direct bypass was patent in 92 % of CMG and 86.7 % of CG, with no significant difference (p = 0.623). Middle meningeal artery blush was observed in 76 % of CMG and 80 % of CG, indicating similar development (p > 0.99). Matsushima angiographic grade was comparable between groups (good: CMG 20 %, CG 6.7 %; fair: CMG 72 %, CG 80 %; poor: CMG 8 %, CG 13.3 %), with no significant differences. The median relative cerebral blood flow significantly increased postoperatively in CMG (preoperative 0.85, postoperative 0.94; p = 0.009) but not in CG (preoperative 0.93, postoperative 0.94; p = 0.455). The two-year stroke-free survival based on duraplasty showed no significant difference (p = 0.726) between groups. Conclusions: Collagen matrix duraplasty does not enhance the postoperative vascularization status after direct bypass surgery in adult-onset MMD in the short term.http://www.sciencedirect.com/science/article/pii/S2590139725000572Moyamoya diseaseDuragenCollagen matrix graftDirect bypassAngiogenesisNeovascularization |
| spellingShingle | Izumi Yamaguchi Yasuhisa Kanematsu Kenji Shimada Masaaki Korai Takeshi Miyamoto Shu Sogabe Manabu Ishihara Tatsuya Haboshi Yasushi Takagi Comparison of postoperative vascularization between collagen matrix duraplasty and conventional duraplasty after direct bypass surgery in Moyamoya disease: A single-institute retrospective cohort study World Neurosurgery: X Moyamoya disease Duragen Collagen matrix graft Direct bypass Angiogenesis Neovascularization |
| title | Comparison of postoperative vascularization between collagen matrix duraplasty and conventional duraplasty after direct bypass surgery in Moyamoya disease: A single-institute retrospective cohort study |
| title_full | Comparison of postoperative vascularization between collagen matrix duraplasty and conventional duraplasty after direct bypass surgery in Moyamoya disease: A single-institute retrospective cohort study |
| title_fullStr | Comparison of postoperative vascularization between collagen matrix duraplasty and conventional duraplasty after direct bypass surgery in Moyamoya disease: A single-institute retrospective cohort study |
| title_full_unstemmed | Comparison of postoperative vascularization between collagen matrix duraplasty and conventional duraplasty after direct bypass surgery in Moyamoya disease: A single-institute retrospective cohort study |
| title_short | Comparison of postoperative vascularization between collagen matrix duraplasty and conventional duraplasty after direct bypass surgery in Moyamoya disease: A single-institute retrospective cohort study |
| title_sort | comparison of postoperative vascularization between collagen matrix duraplasty and conventional duraplasty after direct bypass surgery in moyamoya disease a single institute retrospective cohort study |
| topic | Moyamoya disease Duragen Collagen matrix graft Direct bypass Angiogenesis Neovascularization |
| url | http://www.sciencedirect.com/science/article/pii/S2590139725000572 |
| work_keys_str_mv | AT izumiyamaguchi comparisonofpostoperativevascularizationbetweencollagenmatrixduraplastyandconventionalduraplastyafterdirectbypasssurgeryinmoyamoyadiseaseasingleinstituteretrospectivecohortstudy AT yasuhisakanematsu comparisonofpostoperativevascularizationbetweencollagenmatrixduraplastyandconventionalduraplastyafterdirectbypasssurgeryinmoyamoyadiseaseasingleinstituteretrospectivecohortstudy AT kenjishimada comparisonofpostoperativevascularizationbetweencollagenmatrixduraplastyandconventionalduraplastyafterdirectbypasssurgeryinmoyamoyadiseaseasingleinstituteretrospectivecohortstudy AT masaakikorai comparisonofpostoperativevascularizationbetweencollagenmatrixduraplastyandconventionalduraplastyafterdirectbypasssurgeryinmoyamoyadiseaseasingleinstituteretrospectivecohortstudy AT takeshimiyamoto comparisonofpostoperativevascularizationbetweencollagenmatrixduraplastyandconventionalduraplastyafterdirectbypasssurgeryinmoyamoyadiseaseasingleinstituteretrospectivecohortstudy AT shusogabe comparisonofpostoperativevascularizationbetweencollagenmatrixduraplastyandconventionalduraplastyafterdirectbypasssurgeryinmoyamoyadiseaseasingleinstituteretrospectivecohortstudy AT manabuishihara comparisonofpostoperativevascularizationbetweencollagenmatrixduraplastyandconventionalduraplastyafterdirectbypasssurgeryinmoyamoyadiseaseasingleinstituteretrospectivecohortstudy AT tatsuyahaboshi comparisonofpostoperativevascularizationbetweencollagenmatrixduraplastyandconventionalduraplastyafterdirectbypasssurgeryinmoyamoyadiseaseasingleinstituteretrospectivecohortstudy AT yasushitakagi comparisonofpostoperativevascularizationbetweencollagenmatrixduraplastyandconventionalduraplastyafterdirectbypasssurgeryinmoyamoyadiseaseasingleinstituteretrospectivecohortstudy |