Anti-Toxoplasma Effects of Dracocephalum Polychaetum Essential Oil
Background. Toxoplasma gondii is a common parasitic disease with a cosmopolitan prevalence, causing severe health problems. Although chemotherapy for toxoplasmosis is readily available, most have side effects. Objectives. This study assesses the Dracocephalum polychaetum essential oil against T. gon...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2022/6091834 |
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| author | Faham Khamesipour Amirhossein Pourmohammad Mohsen Jafarian-Dehkordi |
| author_facet | Faham Khamesipour Amirhossein Pourmohammad Mohsen Jafarian-Dehkordi |
| author_sort | Faham Khamesipour |
| collection | DOAJ |
| description | Background. Toxoplasma gondii is a common parasitic disease with a cosmopolitan prevalence, causing severe health problems. Although chemotherapy for toxoplasmosis is readily available, most have side effects. Objectives. This study assesses the Dracocephalum polychaetum essential oil against T. gondii activity. In vitro, the anti-Toxoplasma effects of D. polychaetum essential oils with different concentrations were evaluated. Methods. In the present study, T. gondii RH strain tachyzoites were exposed to D. polychaetum essential oil, and their viability effect on the parasite was evaluated. The viability test of tachyzoites was performed by using the staining method trypan blue in vitro. The inhibitory effect of D. polychaetum extract on T. gondii RH strain tachyzoites in the Vero cell line was evaluated. Results. D. polychaetum has valuable efficacy in vitro, outperforming pyrimethamine and sulfadiazine at 30 and 90 minutes after exposure (p<0.05). D. polychaetum essential oil showed anti-Toxoplasma activity in the cell line (IC50: 241.7 μg/mL). After T. gondii-infected Vero cells had been incubated with different concentrations of the D. polychaetum essential oil, their viability decreased in a dose-dependent manner. Conclusions. In conclusion, D. polychaetum extract as an herbal medicine might be a valuable alternative to routine chemotherapy for toxoplasmosis. |
| format | Article |
| id | doaj-art-990621734a414d47ad6efb3c95705c57 |
| institution | Kabale University |
| issn | 1687-7098 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-990621734a414d47ad6efb3c95705c572025-02-03T01:32:41ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-70982022-01-01202210.1155/2022/6091834Anti-Toxoplasma Effects of Dracocephalum Polychaetum Essential OilFaham Khamesipour0Amirhossein Pourmohammad1Mohsen Jafarian-Dehkordi2Faculty of Veterinary MedicineFaculty of Veterinary MedicineFaculty of Veterinary MedicineBackground. Toxoplasma gondii is a common parasitic disease with a cosmopolitan prevalence, causing severe health problems. Although chemotherapy for toxoplasmosis is readily available, most have side effects. Objectives. This study assesses the Dracocephalum polychaetum essential oil against T. gondii activity. In vitro, the anti-Toxoplasma effects of D. polychaetum essential oils with different concentrations were evaluated. Methods. In the present study, T. gondii RH strain tachyzoites were exposed to D. polychaetum essential oil, and their viability effect on the parasite was evaluated. The viability test of tachyzoites was performed by using the staining method trypan blue in vitro. The inhibitory effect of D. polychaetum extract on T. gondii RH strain tachyzoites in the Vero cell line was evaluated. Results. D. polychaetum has valuable efficacy in vitro, outperforming pyrimethamine and sulfadiazine at 30 and 90 minutes after exposure (p<0.05). D. polychaetum essential oil showed anti-Toxoplasma activity in the cell line (IC50: 241.7 μg/mL). After T. gondii-infected Vero cells had been incubated with different concentrations of the D. polychaetum essential oil, their viability decreased in a dose-dependent manner. Conclusions. In conclusion, D. polychaetum extract as an herbal medicine might be a valuable alternative to routine chemotherapy for toxoplasmosis.http://dx.doi.org/10.1155/2022/6091834 |
| spellingShingle | Faham Khamesipour Amirhossein Pourmohammad Mohsen Jafarian-Dehkordi Anti-Toxoplasma Effects of Dracocephalum Polychaetum Essential Oil Interdisciplinary Perspectives on Infectious Diseases |
| title | Anti-Toxoplasma Effects of Dracocephalum Polychaetum Essential Oil |
| title_full | Anti-Toxoplasma Effects of Dracocephalum Polychaetum Essential Oil |
| title_fullStr | Anti-Toxoplasma Effects of Dracocephalum Polychaetum Essential Oil |
| title_full_unstemmed | Anti-Toxoplasma Effects of Dracocephalum Polychaetum Essential Oil |
| title_short | Anti-Toxoplasma Effects of Dracocephalum Polychaetum Essential Oil |
| title_sort | anti toxoplasma effects of dracocephalum polychaetum essential oil |
| url | http://dx.doi.org/10.1155/2022/6091834 |
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