Enhancement of spinosad production in Saccharopolyspora spinosa by overexpression of the complete 74-kb spinosyn gene cluster

Enhancement of spinosad production in Saccharopolyspora spinosa by overexpression of the complete 74-kb spinosyn gene cluster

Abstract Background Spinosad, a secondary metabolite produced by Saccharopolyspora spinosa, is a polyketide macrolide insecticide with low toxicity and environmental friendliness. Owing to the high level of DNA methylation and unclear regulatory mechanisms, gene engineering to increase spinosad prod...

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Bibliographic Details
Main Authors: Lu Gan, Zhengyu Zhang, Jingtao Chen, Zhichun Shen, Wujie Chen, Shaoxin Chen, Jiyang Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Microbial Cell Factories
Subjects:
Saccharopolyspora spinosa
Spinosad
Overexpression
Spinosyn gene cluster
Online Access:https://doi.org/10.1186/s12934-025-02724-x
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