Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level
The recently discovered IL-33 as an IL-1 cytokine family member has been proved to be specifically released from osteonecrotic bones. We aimed to investigate the potential role of IL-33 in the development of osteonecrosis of femoral head (ONFH). Forty patients diagnosed with ONFH and forty age-, sex...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/1732638 |
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| _version_ | 1832560405171404800 |
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| author | Jinhui Ma Wanshou Guo Zirong Li Bailiang Wang Shirui Li Peng Wang |
| author_facet | Jinhui Ma Wanshou Guo Zirong Li Bailiang Wang Shirui Li Peng Wang |
| author_sort | Jinhui Ma |
| collection | DOAJ |
| description | The recently discovered IL-33 as an IL-1 cytokine family member has been proved to be specifically released from osteonecrotic bones. We aimed to investigate the potential role of IL-33 in the development of osteonecrosis of femoral head (ONFH). Forty patients diagnosed with ONFH and forty age-, sex-, and body mass index- (BMI-) matched healthy subjects were included in this prospective study between March 2016 and September 2016. A commercially available ELISA kit was used to test the level of plasma IL-33. The IL-33 levels were compared among different ARCO stages, CJFH types, and etiology groups. Plasma IL-33 levels were significantly higher in the ONFH patients than that in the control subjects. The levels of IL-33 did not differ significantly among the ONFH patients with different ARCO stages. The IL-33 levels of patients with CJFH type L3 were significantly higher than that of patients with types L1 and L2. No significant differences were observed in IL-33 levels between steroid-induced, alcohol-induced, and idiopathic patients. Our findings seem to indicate that IL-33 effects may be detrimental during ONFH, which appeared to be associated with the prognosis of ONFH. The IL-33 deserves particular attention in the pathogenesis of ONFH. |
| format | Article |
| id | doaj-art-9905bb46b1534951a58c67abbf12728b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9905bb46b1534951a58c67abbf12728b2025-02-03T01:27:47ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/17326381732638Hip Osteonecrosis Is Associated with Increased Plasma IL-33 LevelJinhui Ma0Wanshou Guo1Zirong Li2Bailiang Wang3Shirui Li4Peng Wang5Department of Bone and Joint Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, ChinaDepartment of Bone and Joint Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, ChinaDepartment of Bone and Joint Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, ChinaDepartment of Bone and Joint Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, ChinaDepartment of Endocrinology, China-Japan Friendship Hospital, Beijing 100029, ChinaDepartment of Endocrinology, China-Japan Friendship Hospital, Beijing 100029, ChinaThe recently discovered IL-33 as an IL-1 cytokine family member has been proved to be specifically released from osteonecrotic bones. We aimed to investigate the potential role of IL-33 in the development of osteonecrosis of femoral head (ONFH). Forty patients diagnosed with ONFH and forty age-, sex-, and body mass index- (BMI-) matched healthy subjects were included in this prospective study between March 2016 and September 2016. A commercially available ELISA kit was used to test the level of plasma IL-33. The IL-33 levels were compared among different ARCO stages, CJFH types, and etiology groups. Plasma IL-33 levels were significantly higher in the ONFH patients than that in the control subjects. The levels of IL-33 did not differ significantly among the ONFH patients with different ARCO stages. The IL-33 levels of patients with CJFH type L3 were significantly higher than that of patients with types L1 and L2. No significant differences were observed in IL-33 levels between steroid-induced, alcohol-induced, and idiopathic patients. Our findings seem to indicate that IL-33 effects may be detrimental during ONFH, which appeared to be associated with the prognosis of ONFH. The IL-33 deserves particular attention in the pathogenesis of ONFH.http://dx.doi.org/10.1155/2017/1732638 |
| spellingShingle | Jinhui Ma Wanshou Guo Zirong Li Bailiang Wang Shirui Li Peng Wang Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level Mediators of Inflammation |
| title | Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level |
| title_full | Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level |
| title_fullStr | Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level |
| title_full_unstemmed | Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level |
| title_short | Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level |
| title_sort | hip osteonecrosis is associated with increased plasma il 33 level |
| url | http://dx.doi.org/10.1155/2017/1732638 |
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