Cell Therapy as a Way to Increase the Effectiveness of Hematopoietic Stem Cell Transplantation
Hematopoietic stem cell transplantation (HSCT) is a standard method for treating a number of pathologies, primarily blood diseases. Timely restoration of the immune system after HSCT is a critical factor associated with the development of complications such as relapses or secondary tumors and variou...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/24/2056 |
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| author | Ekaterina Pashkina Elena Blinova Maria Bykova Alina Aktanova Vera Denisova |
| author_facet | Ekaterina Pashkina Elena Blinova Maria Bykova Alina Aktanova Vera Denisova |
| author_sort | Ekaterina Pashkina |
| collection | DOAJ |
| description | Hematopoietic stem cell transplantation (HSCT) is a standard method for treating a number of pathologies, primarily blood diseases. Timely restoration of the immune system after HSCT is a critical factor associated with the development of complications such as relapses or secondary tumors and various infections, as well as the graft-versus-host reaction in allogeneic transplantation, which ultimately affects the survival of patients. Introduction into the recipient’s body of immune system cells that are incapable of sensitization by recipient antigens during the period of immune reconstitution can increase the rate of restoration of the immune system, as well as reduce the risk of complications. This review presents the results of studies on cell therapy with various cell subpopulations of both bone marrow and mesenchymal origin during HSCT. |
| format | Article |
| id | doaj-art-99019bdb8090499b8f01e590c29320d3 |
| institution | OA Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-99019bdb8090499b8f01e590c29320d32025-08-20T02:00:39ZengMDPI AGCells2073-44092024-12-011324205610.3390/cells13242056Cell Therapy as a Way to Increase the Effectiveness of Hematopoietic Stem Cell TransplantationEkaterina Pashkina0Elena Blinova1Maria Bykova2Alina Aktanova3Vera Denisova4Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya st., 630099 Novosibirsk, RussiaResearch Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya st., 630099 Novosibirsk, RussiaResearch Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya st., 630099 Novosibirsk, RussiaResearch Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya st., 630099 Novosibirsk, RussiaResearch Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya st., 630099 Novosibirsk, RussiaHematopoietic stem cell transplantation (HSCT) is a standard method for treating a number of pathologies, primarily blood diseases. Timely restoration of the immune system after HSCT is a critical factor associated with the development of complications such as relapses or secondary tumors and various infections, as well as the graft-versus-host reaction in allogeneic transplantation, which ultimately affects the survival of patients. Introduction into the recipient’s body of immune system cells that are incapable of sensitization by recipient antigens during the period of immune reconstitution can increase the rate of restoration of the immune system, as well as reduce the risk of complications. This review presents the results of studies on cell therapy with various cell subpopulations of both bone marrow and mesenchymal origin during HSCT.https://www.mdpi.com/2073-4409/13/24/2056cell therapyimmune recoveryhematopoietic stem cell transplantation |
| spellingShingle | Ekaterina Pashkina Elena Blinova Maria Bykova Alina Aktanova Vera Denisova Cell Therapy as a Way to Increase the Effectiveness of Hematopoietic Stem Cell Transplantation Cells cell therapy immune recovery hematopoietic stem cell transplantation |
| title | Cell Therapy as a Way to Increase the Effectiveness of Hematopoietic Stem Cell Transplantation |
| title_full | Cell Therapy as a Way to Increase the Effectiveness of Hematopoietic Stem Cell Transplantation |
| title_fullStr | Cell Therapy as a Way to Increase the Effectiveness of Hematopoietic Stem Cell Transplantation |
| title_full_unstemmed | Cell Therapy as a Way to Increase the Effectiveness of Hematopoietic Stem Cell Transplantation |
| title_short | Cell Therapy as a Way to Increase the Effectiveness of Hematopoietic Stem Cell Transplantation |
| title_sort | cell therapy as a way to increase the effectiveness of hematopoietic stem cell transplantation |
| topic | cell therapy immune recovery hematopoietic stem cell transplantation |
| url | https://www.mdpi.com/2073-4409/13/24/2056 |
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