Role of periodontal pathogens in carcinogenesis of squamous-cell carcinoma of the oral mucosa
The study objective is to evaluate the effect of periodontal microorganisms on development of squamous-cell carcinoma of the oral mucosa and the risk of its recurrence.Materials and methods. Microbiological study of biomaterials from 150 patients was performed. The study group included 100 patients...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2021-01-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/583 |
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| author | A. E. Kazimov A. M. Mudunov Z. V. Grigorievskaya I. A. Zaderenko S. B. Alieva N. S. Bagirova I. N. Petukhova I. V. Tereshchenko M. B. Pak |
| author_facet | A. E. Kazimov A. M. Mudunov Z. V. Grigorievskaya I. A. Zaderenko S. B. Alieva N. S. Bagirova I. N. Petukhova I. V. Tereshchenko M. B. Pak |
| author_sort | A. E. Kazimov |
| collection | DOAJ |
| description | The study objective is to evaluate the effect of periodontal microorganisms on development of squamous-cell carcinoma of the oral mucosa and the risk of its recurrence.Materials and methods. Microbiological study of biomaterials from 150 patients was performed. The study group included 100 patients with T3–T4 squamous-cell carcinoma of the oral mucosa and was subdivided into two subgroups with 50 patients in each. The control group included 50 patients.Results. Analysis of the results obtained in the subgroup of primary patients showed the following trends: in 2 (50 %) of 4 patients with Fusobacterium spp., recurrence of the main disease was observed as well as a case of distant metastasis into the bones. Among 35 patients with Prevotella spp. in the biomaterials, in 16 (45.7 %) recurrence of the tumor was observed. Among 10 patients with Veillonella spp., recurrence was observed in 20 %. The most common aerobic microorganism was Streptococcus spр. Among patients who underwent treatment at the N.N. Blokhin National Medical Research Center of Oncology, recurrence was diagnosed in 28.5 %, distant metastases in 4.7 %. In the subgroup of repeat patients, the following trends were observed: among 27 patients with Fusobacterium spp., recurrence of the main disease was observed in 63 %. Among 26 patients with Prevotella spp. in the biomaterial, in 11 (42.3 %) local recurrence was observed. Among 24 patients with Veillonella spp., recurrence developed in 33.3 %. The most common aerobic microorganism was Streptococcus spр., recurrences developed in 21 % of cases. |
| format | Article |
| id | doaj-art-99019572bd984445b9024b7a888681a7 |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2021-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-99019572bd984445b9024b7a888681a72025-08-20T03:59:48ZrusABV-pressОпухоли головы и шеи2222-14682411-46342021-01-01104748510.17650/2222-1468-2020-10-4-74-85421Role of periodontal pathogens in carcinogenesis of squamous-cell carcinoma of the oral mucosaA. E. Kazimov0A. M. Mudunov1Z. V. Grigorievskaya2I. A. Zaderenko3S. B. Alieva4N. S. Bagirova5I. N. Petukhova6I. V. Tereshchenko7M. B. Pak8N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaLapino Clinical HospitalN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaThe study objective is to evaluate the effect of periodontal microorganisms on development of squamous-cell carcinoma of the oral mucosa and the risk of its recurrence.Materials and methods. Microbiological study of biomaterials from 150 patients was performed. The study group included 100 patients with T3–T4 squamous-cell carcinoma of the oral mucosa and was subdivided into two subgroups with 50 patients in each. The control group included 50 patients.Results. Analysis of the results obtained in the subgroup of primary patients showed the following trends: in 2 (50 %) of 4 patients with Fusobacterium spp., recurrence of the main disease was observed as well as a case of distant metastasis into the bones. Among 35 patients with Prevotella spp. in the biomaterials, in 16 (45.7 %) recurrence of the tumor was observed. Among 10 patients with Veillonella spp., recurrence was observed in 20 %. The most common aerobic microorganism was Streptococcus spр. Among patients who underwent treatment at the N.N. Blokhin National Medical Research Center of Oncology, recurrence was diagnosed in 28.5 %, distant metastases in 4.7 %. In the subgroup of repeat patients, the following trends were observed: among 27 patients with Fusobacterium spp., recurrence of the main disease was observed in 63 %. Among 26 patients with Prevotella spp. in the biomaterial, in 11 (42.3 %) local recurrence was observed. Among 24 patients with Veillonella spp., recurrence developed in 33.3 %. The most common aerobic microorganism was Streptococcus spр., recurrences developed in 21 % of cases.https://ogsh.abvpress.ru/jour/article/view/583periodontic pathogenssquamous-cell carcinomaprevotella spp.fusobacterium spp.veillonella spp.gemella spp.treponema denticola |
| spellingShingle | A. E. Kazimov A. M. Mudunov Z. V. Grigorievskaya I. A. Zaderenko S. B. Alieva N. S. Bagirova I. N. Petukhova I. V. Tereshchenko M. B. Pak Role of periodontal pathogens in carcinogenesis of squamous-cell carcinoma of the oral mucosa Опухоли головы и шеи periodontic pathogens squamous-cell carcinoma prevotella spp. fusobacterium spp. veillonella spp. gemella spp. treponema denticola |
| title | Role of periodontal pathogens in carcinogenesis of squamous-cell carcinoma of the oral mucosa |
| title_full | Role of periodontal pathogens in carcinogenesis of squamous-cell carcinoma of the oral mucosa |
| title_fullStr | Role of periodontal pathogens in carcinogenesis of squamous-cell carcinoma of the oral mucosa |
| title_full_unstemmed | Role of periodontal pathogens in carcinogenesis of squamous-cell carcinoma of the oral mucosa |
| title_short | Role of periodontal pathogens in carcinogenesis of squamous-cell carcinoma of the oral mucosa |
| title_sort | role of periodontal pathogens in carcinogenesis of squamous cell carcinoma of the oral mucosa |
| topic | periodontic pathogens squamous-cell carcinoma prevotella spp. fusobacterium spp. veillonella spp. gemella spp. treponema denticola |
| url | https://ogsh.abvpress.ru/jour/article/view/583 |
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