Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores.

Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores.

Growing evidences indicate that proteases are implicated in adipogenesis and in the onset of obesity. We previously reported that the cysteine protease cathepsin K (ctsk) is overexpressed in the white adipose tissue (WAT) of obese individuals. We herein characterized the WAT and the metabolic phenot...

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Main Authors: Marcella Funicello, Michela Novelli, Maurizio Ragni, Teresa Vottari, Cesare Cocuzza, Joaquin Soriano-Lopez, Chiara Chiellini, Federico Boschi, Pasquina Marzola, Pellegrino Masiello, Paul Saftig, Ferruccio Santini, Rene St-Jacques, Sylvie Desmarais, Nicolas Morin, Joseph Mancini, M David Percival, Aldo Pinchera, Margherita Maffei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-08-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000683&type=printable
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