Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALB/c Mice
Crinum macowanii is a bulbous plant indigenous to many parts of Southern Africa. Extracts of C. macowanii have gained interest since the discovery of various alkaloids, few of which possess acetylcholinesterase inhibitory activity. The present study was performed to evaluate the effect of a crude hy...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2018/2057219 |
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| author | Mohammed S. Jilani Dexter Tagwireyi Louis L. Gadaga Charles C. Maponga Cosmas Mutsimhu |
| author_facet | Mohammed S. Jilani Dexter Tagwireyi Louis L. Gadaga Charles C. Maponga Cosmas Mutsimhu |
| author_sort | Mohammed S. Jilani |
| collection | DOAJ |
| description | Crinum macowanii is a bulbous plant indigenous to many parts of Southern Africa. Extracts of C. macowanii have gained interest since the discovery of various alkaloids, few of which possess acetylcholinesterase inhibitory activity. The present study was performed to evaluate the effect of a crude hydroethanolic extract of C. macowanii against aluminum chloride-induced memory impairment in mice using the Morris water maze and the novel object recognition task. C. macowanii (10, 20, and 40 mg/kg p.o) was administered daily for five weeks, while donepezil (3 mg/kg p.o) was used as the positive control. C. macowanii at a dosage of 40 mg/kg showed a significantly lower escape latency than the negative control (P<0.0001) and was found to be comparable to donepezil 3 mg/kg in the Morris water maze test. C. macowanii at 40 mg/kg exhibited a significantly higher discrimination index than aluminum chloride-treated mice in the novel object recognition task. The results may support the usefulness of C. macowanii in the management of dementia and related illnesses. |
| format | Article |
| id | doaj-art-98fdb4592e9e4ed3acd7a1eab23690a6 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-98fdb4592e9e4ed3acd7a1eab23690a62025-02-03T01:28:15ZengWileyBehavioural Neurology0953-41801875-85842018-01-01201810.1155/2018/20572192057219Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALB/c MiceMohammed S. Jilani0Dexter Tagwireyi1Louis L. Gadaga2Charles C. Maponga3Cosmas Mutsimhu4Drug and Toxicology Information Service (DaTIS), School of Pharmacy and Department of Clinical Pharmacology, College of Health Sciences, University of Zimbabwe, P.O. Box A 178, Avondale, Harare, ZimbabweDrug and Toxicology Information Service (DaTIS), School of Pharmacy and Department of Clinical Pharmacology, College of Health Sciences, University of Zimbabwe, P.O. Box A 178, Avondale, Harare, ZimbabweDrug and Toxicology Information Service (DaTIS), School of Pharmacy and Department of Clinical Pharmacology, College of Health Sciences, University of Zimbabwe, P.O. Box A 178, Avondale, Harare, ZimbabweSchool of Pharmacy, University of Zimbabwe, P.O. Box MP167, Mount Pleasant, Harare, ZimbabweDrug and Toxicology Information Service (DaTIS), School of Pharmacy and Department of Clinical Pharmacology, College of Health Sciences, University of Zimbabwe, P.O. Box A 178, Avondale, Harare, ZimbabweCrinum macowanii is a bulbous plant indigenous to many parts of Southern Africa. Extracts of C. macowanii have gained interest since the discovery of various alkaloids, few of which possess acetylcholinesterase inhibitory activity. The present study was performed to evaluate the effect of a crude hydroethanolic extract of C. macowanii against aluminum chloride-induced memory impairment in mice using the Morris water maze and the novel object recognition task. C. macowanii (10, 20, and 40 mg/kg p.o) was administered daily for five weeks, while donepezil (3 mg/kg p.o) was used as the positive control. C. macowanii at a dosage of 40 mg/kg showed a significantly lower escape latency than the negative control (P<0.0001) and was found to be comparable to donepezil 3 mg/kg in the Morris water maze test. C. macowanii at 40 mg/kg exhibited a significantly higher discrimination index than aluminum chloride-treated mice in the novel object recognition task. The results may support the usefulness of C. macowanii in the management of dementia and related illnesses.http://dx.doi.org/10.1155/2018/2057219 |
| spellingShingle | Mohammed S. Jilani Dexter Tagwireyi Louis L. Gadaga Charles C. Maponga Cosmas Mutsimhu Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALB/c Mice Behavioural Neurology |
| title | Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALB/c Mice |
| title_full | Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALB/c Mice |
| title_fullStr | Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALB/c Mice |
| title_full_unstemmed | Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALB/c Mice |
| title_short | Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALB/c Mice |
| title_sort | cognitive enhancing effect of a hydroethanolic extract of crinum macowanii against memory impairment induced by aluminum chloride in balb c mice |
| url | http://dx.doi.org/10.1155/2018/2057219 |
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