Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride
Eudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL). The optimum EE-SA complexation mass ratio was determined using viscosity measurements. Interactions between EE and SA in PECs were characte...
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| Format: | Article |
| Language: | English |
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Sciendo
2014-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | http://www.degruyter.com/view/j/acph.2014.64.issue-1/acph-2014-0010/acph-2014-0010.xml?format=INT |
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| author | Yusif Rehab Mohammad Hashim Irhan Ibrahim Abu El-Dahan Marwa Salah |
| author_facet | Yusif Rehab Mohammad Hashim Irhan Ibrahim Abu El-Dahan Marwa Salah |
| author_sort | Yusif Rehab Mohammad |
| collection | DOAJ |
| description | Eudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL). The optimum EE-SA complexation mass ratio was determined using viscosity measurements. Interactions between EE and SA in PECs were characterized by Fourier transform infra-red spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Diltiazem hydrochloride (DTZ HCl) tablets were prepared using the prepared EE-SA PECs and their physical mixtures at different ratios as matrices. Tablets were evaluated for swelling characteristics and in vitro drug release. Tablets containing EE-SAH physical mixtures of ratios (1.5:1 and 1:3) as matrices were effective in achieving sustained release of DTZ HCl, where the percent drug released was significantly (p < 0.05) decreased compared to that from tablets either containing the same ratios of EE-SAL physical mixtures or the preformed EE- -SAH and EE-SAL PECs. |
| format | Article |
| id | doaj-art-98fcb00321b84d9293be5d7efa5cbbfb |
| institution | Kabale University |
| issn | 1330-0075 1846-9558 |
| language | English |
| publishDate | 2014-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-98fcb00321b84d9293be5d7efa5cbbfb2025-02-03T02:13:52ZengSciendoActa Pharmaceutica1330-00751846-95582014-03-016418910410.2478/acph-2014-0010acph-2014-0010Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochlorideYusif Rehab Mohammad0Hashim Irhan Ibrahim Abu1El-Dahan Marwa Salah2Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, EgyptDepartment of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, EgyptDepartment of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, EgyptEudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL). The optimum EE-SA complexation mass ratio was determined using viscosity measurements. Interactions between EE and SA in PECs were characterized by Fourier transform infra-red spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Diltiazem hydrochloride (DTZ HCl) tablets were prepared using the prepared EE-SA PECs and their physical mixtures at different ratios as matrices. Tablets were evaluated for swelling characteristics and in vitro drug release. Tablets containing EE-SAH physical mixtures of ratios (1.5:1 and 1:3) as matrices were effective in achieving sustained release of DTZ HCl, where the percent drug released was significantly (p < 0.05) decreased compared to that from tablets either containing the same ratios of EE-SAL physical mixtures or the preformed EE- -SAH and EE-SAL PECs.http://www.degruyter.com/view/j/acph.2014.64.issue-1/acph-2014-0010/acph-2014-0010.xml?format=INTpolyelectrolyte complexdiltiazem hydrochlorideEudragit E 100sodium alginateviscositytablet matrix |
| spellingShingle | Yusif Rehab Mohammad Hashim Irhan Ibrahim Abu El-Dahan Marwa Salah Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride Acta Pharmaceutica polyelectrolyte complex diltiazem hydrochloride Eudragit E 100 sodium alginate viscosity tablet matrix |
| title | Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride |
| title_full | Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride |
| title_fullStr | Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride |
| title_full_unstemmed | Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride |
| title_short | Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride |
| title_sort | some variables affecting the characteristics of eudragit e sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride |
| topic | polyelectrolyte complex diltiazem hydrochloride Eudragit E 100 sodium alginate viscosity tablet matrix |
| url | http://www.degruyter.com/view/j/acph.2014.64.issue-1/acph-2014-0010/acph-2014-0010.xml?format=INT |
| work_keys_str_mv | AT yusifrehabmohammad somevariablesaffectingthecharacteristicsofeudragitesodiumalginatepolyelectrolytecomplexasatabletmatrixfordiltiazemhydrochloride AT hashimirhanibrahimabu somevariablesaffectingthecharacteristicsofeudragitesodiumalginatepolyelectrolytecomplexasatabletmatrixfordiltiazemhydrochloride AT eldahanmarwasalah somevariablesaffectingthecharacteristicsofeudragitesodiumalginatepolyelectrolytecomplexasatabletmatrixfordiltiazemhydrochloride |