Retinal parameter analysis and diagnostic potentail exploration in familial exudative vitreoretinopathy using ultra-widefield fundus photography
Abstract Background Familial Exudative Vitreoretinopathy (FEVR) is a monogenic disorder causing retinal vascular impairment, often underdiagnosed due to its variable presentation and reliance on invasive methods like fundus fluorescein angiography (FFA). Through the utilization of non-invasive ultra...
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BMC
2025-07-01
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| Series: | International Journal of Retina and Vitreous |
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| Online Access: | https://doi.org/10.1186/s40942-025-00716-y |
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| author | Jiayu Li Shaochi Zhang Xiaolong Qi Chanjuan Wang Wen Zhang Rui Li Caihong Sun Keyan Liu Xiaolu Li Wenjuan Zhuang |
| author_facet | Jiayu Li Shaochi Zhang Xiaolong Qi Chanjuan Wang Wen Zhang Rui Li Caihong Sun Keyan Liu Xiaolu Li Wenjuan Zhuang |
| author_sort | Jiayu Li |
| collection | DOAJ |
| description | Abstract Background Familial Exudative Vitreoretinopathy (FEVR) is a monogenic disorder causing retinal vascular impairment, often underdiagnosed due to its variable presentation and reliance on invasive methods like fundus fluorescein angiography (FFA). Through the utilization of non-invasive ultra-widefield fundus photography (UWFFP), this research explored both the diagnostic potential of integrated retinal parameters for the detection of FEVR, and their characteristic changes during the early stage progression. Methods Retinal parameters were systematically extracted and quantified from UWFFP of 114 FEVR patients and 114 matched controls using the EVision AI cloud platform. Comparative statistical analyses were performed to identify significant intergroup differences between FEVR and control cohorts, and assess intra-group variations among FEVR subgroups. Based on parameters that showed significant differences between the FEVR group and the control group and had an impact on the FEVR group, a diagnostic model was constructed. Receiver operating characteristic (ROC) curves were plotted to determine the diagnostic potential of these parameters. In addition, subgroup analysis within the FEVR group was conducted to clarify the relationship between retinal parameters and disease staging. Results Significant differences were observed in 25 retinal parameters between the FEVR group and the control group, with the horizontal cup-to-disc ratio, vertical cup-to-disc ratio, optic disc-to-macula distance, and vascular density demonstrating potential diagnostic efficacy. Subgroup analysis within the FEVR group revealed that as the disease stage advanced and severity increased, the optic disc and cup diameters decreased, the optic disc-to-macula distance increased, and the vascular fractal dimension and vascular density parameters declined. Conclusions UWFFP and automated retinal parameter analysis offer promising tools for early FEVR diagnosis, with specific structural and vascular markers providing diagnostic potential. Further large-scale studies are needed to validate these findings and refine diagnostic models. |
| format | Article |
| id | doaj-art-98fb247bcdde43629a018fb8e510f701 |
| institution | DOAJ |
| issn | 2056-9920 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj-art-98fb247bcdde43629a018fb8e510f7012025-08-20T03:05:13ZengBMCInternational Journal of Retina and Vitreous2056-99202025-07-0111111010.1186/s40942-025-00716-yRetinal parameter analysis and diagnostic potentail exploration in familial exudative vitreoretinopathy using ultra-widefield fundus photographyJiayu Li0Shaochi Zhang1Xiaolong Qi2Chanjuan Wang3Wen Zhang4Rui Li5Caihong Sun6Keyan Liu7Xiaolu Li8Wenjuan Zhuang9Department of Ophthalmology, People’s Hospital of Ningxia Hui Autonomous Region (Affiliated Hospital of Ningxia Medical University)Department of Ophthalmology, People’s Hospital of Ningxia Hui Autonomous Region (Affiliated Hospital of Ningxia Medical University)Department of Ophthalmology, People’s Hospital of Ningxia Hui Autonomous Region (Affiliated Hospital of Ningxia Medical University)Department of Ophthalmology, People’s Hospital of Ningxia Hui Autonomous Region (Affiliated Hospital of Ningxia Medical University)Department of Ophthalmology, People’s Hospital of Ningxia Hui Autonomous Region (Affiliated Hospital of Ningxia Medical University)Third Clinical Medical College of Ningxia Medical UniversityDepartment of Ophthalmology, People’s Hospital of Ningxia Hui Autonomous Region (Affiliated Hospital of Ningxia Medical University)Third Clinical Medical College of Ningxia Medical UniversityDepartment of Ophthalmology, People’s Hospital of Ningxia Hui Autonomous Region (Affiliated Hospital of Ningxia Medical University)Department of Ophthalmology, People’s Hospital of Ningxia Hui Autonomous Region (Affiliated Hospital of Ningxia Medical University)Abstract Background Familial Exudative Vitreoretinopathy (FEVR) is a monogenic disorder causing retinal vascular impairment, often underdiagnosed due to its variable presentation and reliance on invasive methods like fundus fluorescein angiography (FFA). Through the utilization of non-invasive ultra-widefield fundus photography (UWFFP), this research explored both the diagnostic potential of integrated retinal parameters for the detection of FEVR, and their characteristic changes during the early stage progression. Methods Retinal parameters were systematically extracted and quantified from UWFFP of 114 FEVR patients and 114 matched controls using the EVision AI cloud platform. Comparative statistical analyses were performed to identify significant intergroup differences between FEVR and control cohorts, and assess intra-group variations among FEVR subgroups. Based on parameters that showed significant differences between the FEVR group and the control group and had an impact on the FEVR group, a diagnostic model was constructed. Receiver operating characteristic (ROC) curves were plotted to determine the diagnostic potential of these parameters. In addition, subgroup analysis within the FEVR group was conducted to clarify the relationship between retinal parameters and disease staging. Results Significant differences were observed in 25 retinal parameters between the FEVR group and the control group, with the horizontal cup-to-disc ratio, vertical cup-to-disc ratio, optic disc-to-macula distance, and vascular density demonstrating potential diagnostic efficacy. Subgroup analysis within the FEVR group revealed that as the disease stage advanced and severity increased, the optic disc and cup diameters decreased, the optic disc-to-macula distance increased, and the vascular fractal dimension and vascular density parameters declined. Conclusions UWFFP and automated retinal parameter analysis offer promising tools for early FEVR diagnosis, with specific structural and vascular markers providing diagnostic potential. Further large-scale studies are needed to validate these findings and refine diagnostic models.https://doi.org/10.1186/s40942-025-00716-yFamilial exudative vitreoretinopathyUltra-widefield fundus photographyRetinal parameters |
| spellingShingle | Jiayu Li Shaochi Zhang Xiaolong Qi Chanjuan Wang Wen Zhang Rui Li Caihong Sun Keyan Liu Xiaolu Li Wenjuan Zhuang Retinal parameter analysis and diagnostic potentail exploration in familial exudative vitreoretinopathy using ultra-widefield fundus photography International Journal of Retina and Vitreous Familial exudative vitreoretinopathy Ultra-widefield fundus photography Retinal parameters |
| title | Retinal parameter analysis and diagnostic potentail exploration in familial exudative vitreoretinopathy using ultra-widefield fundus photography |
| title_full | Retinal parameter analysis and diagnostic potentail exploration in familial exudative vitreoretinopathy using ultra-widefield fundus photography |
| title_fullStr | Retinal parameter analysis and diagnostic potentail exploration in familial exudative vitreoretinopathy using ultra-widefield fundus photography |
| title_full_unstemmed | Retinal parameter analysis and diagnostic potentail exploration in familial exudative vitreoretinopathy using ultra-widefield fundus photography |
| title_short | Retinal parameter analysis and diagnostic potentail exploration in familial exudative vitreoretinopathy using ultra-widefield fundus photography |
| title_sort | retinal parameter analysis and diagnostic potentail exploration in familial exudative vitreoretinopathy using ultra widefield fundus photography |
| topic | Familial exudative vitreoretinopathy Ultra-widefield fundus photography Retinal parameters |
| url | https://doi.org/10.1186/s40942-025-00716-y |
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