Role of topoisomerase II α and Ki -67 biomarkers in pituitary tumors
Background: Pituitary Adenoma, a neoplastic proliferation of anterior pituitary hormone producing cells, is mainly considered benign but some are clinically aggressive and recurrent and very rarely malignant. From recent advances in pathological and molecular study, there is a continuous search for...
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Association of Clinical Pathologists of Nepal
2023-12-01
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| Series: | Journal of Pathology of Nepal |
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| Online Access: | https://www.nepjol.info/index.php/JPN/article/view/51016 |
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| author | Chhanda Das Madhumita Mukhopadhyay Satinath Mukhopadhyay Avijit Hazra |
| author_facet | Chhanda Das Madhumita Mukhopadhyay Satinath Mukhopadhyay Avijit Hazra |
| author_sort | Chhanda Das |
| collection | DOAJ |
| description | Background: Pituitary Adenoma, a neoplastic proliferation of anterior pituitary hormone producing cells, is mainly considered benign but some are clinically aggressive and recurrent and very rarely malignant. From recent advances in pathological and molecular study, there is a continuous search for numerous prognostic biomarkers, to analyze better tumor behavior and prediction of response to treatment and recurrences. This study was conducted to see the epidemiological spectrum of pituitary tumors and to evaluate the correlation of TOPOISOMERASE IIα (Topo 2A), and Ki-67 biomarker with recurrence, aggressiveness, hormone subtype, radiological invasiveness, and prognostic grade of pituitary tumors.
Materials and methods:This was a prospective study with a total of 54 cases. We studied the clinical behavior, radiology, histopathological findings, and immunohistochemistry with Ki-67, Topoisomerase IIα, over 3 years at a tertiary care center.
Results:When comparing Ki-67 expression with aggressiveness, a high degree of statistical significance was found (Mann -Whitney U Test, p-value <0.001 ). All of our aggressive tumors (8/54) had a Ki-67 level of≥3% while most of the nonaggressive tumors (46/54) had a Ki-67 level of <3%. When comparing Topo 2A expression with recurrence, a high degree of statistical significance was found (Mann Whitney U test, P value <0.001). Most of the recurrent tumor (11/15) had Topo 2A index of 1 % or more.
Conclusions: The benign, aggressive, recurrence, or malignant nature of PA can be effectively predicted with the help of immunohistochemistry such as TOPO 2A and Ki67, thereby guiding better patient management. |
| format | Article |
| id | doaj-art-98fad174d4044d91a3e412a74cd83c8d |
| institution | Kabale University |
| issn | 2091-0797 2091-0908 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Association of Clinical Pathologists of Nepal |
| record_format | Article |
| series | Journal of Pathology of Nepal |
| spelling | doaj-art-98fad174d4044d91a3e412a74cd83c8d2025-08-21T06:46:38ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082023-12-011322037204210.3126/jpn.v13i2.5101678084Role of topoisomerase II α and Ki -67 biomarkers in pituitary tumorsChhanda Das0https://orcid.org/0000-0001-7859-875XMadhumita Mukhopadhyay1Satinath Mukhopadhyay2Avijit Hazra3Burdwan Medical CollegeIPGME&R, Kolkata, IndiaIPGME&R, Kolkata, IndiaIPGME&R, Kolkata, IndiaBackground: Pituitary Adenoma, a neoplastic proliferation of anterior pituitary hormone producing cells, is mainly considered benign but some are clinically aggressive and recurrent and very rarely malignant. From recent advances in pathological and molecular study, there is a continuous search for numerous prognostic biomarkers, to analyze better tumor behavior and prediction of response to treatment and recurrences. This study was conducted to see the epidemiological spectrum of pituitary tumors and to evaluate the correlation of TOPOISOMERASE IIα (Topo 2A), and Ki-67 biomarker with recurrence, aggressiveness, hormone subtype, radiological invasiveness, and prognostic grade of pituitary tumors. Materials and methods:This was a prospective study with a total of 54 cases. We studied the clinical behavior, radiology, histopathological findings, and immunohistochemistry with Ki-67, Topoisomerase IIα, over 3 years at a tertiary care center. Results:When comparing Ki-67 expression with aggressiveness, a high degree of statistical significance was found (Mann -Whitney U Test, p-value <0.001 ). All of our aggressive tumors (8/54) had a Ki-67 level of≥3% while most of the nonaggressive tumors (46/54) had a Ki-67 level of <3%. When comparing Topo 2A expression with recurrence, a high degree of statistical significance was found (Mann Whitney U test, P value <0.001). Most of the recurrent tumor (11/15) had Topo 2A index of 1 % or more. Conclusions: The benign, aggressive, recurrence, or malignant nature of PA can be effectively predicted with the help of immunohistochemistry such as TOPO 2A and Ki67, thereby guiding better patient management.https://www.nepjol.info/index.php/JPN/article/view/51016immunohistochemistryki67pituitary adenomaprognosistopoisomerase iiα |
| spellingShingle | Chhanda Das Madhumita Mukhopadhyay Satinath Mukhopadhyay Avijit Hazra Role of topoisomerase II α and Ki -67 biomarkers in pituitary tumors Journal of Pathology of Nepal immunohistochemistry ki67 pituitary adenoma prognosis topoisomerase iiα |
| title | Role of topoisomerase II α and Ki -67 biomarkers in pituitary tumors |
| title_full | Role of topoisomerase II α and Ki -67 biomarkers in pituitary tumors |
| title_fullStr | Role of topoisomerase II α and Ki -67 biomarkers in pituitary tumors |
| title_full_unstemmed | Role of topoisomerase II α and Ki -67 biomarkers in pituitary tumors |
| title_short | Role of topoisomerase II α and Ki -67 biomarkers in pituitary tumors |
| title_sort | role of topoisomerase ii α and ki 67 biomarkers in pituitary tumors |
| topic | immunohistochemistry ki67 pituitary adenoma prognosis topoisomerase iiα |
| url | https://www.nepjol.info/index.php/JPN/article/view/51016 |
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