Theory of cancer and immunological aspects of carcinoand leukemogenesis
The article overviews some theories of carcino- and leukemogenesis (viral, viralgenetic, viralimmunogenetic, immunological, polyetiological, chemical, mutational, hormonal, oncogenic, antiviral, embryonal, homotoxicological, of parasitic nature etc.). It summarizes some factors contributing to the e...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal Agricultural Research Center of the North-East named N.V. Rudnitsky
2017-06-01
|
| Series: | Аграрная наука Евро-Северо-Востока |
| Subjects: | |
| Online Access: | https://www.agronauka-sv.ru/jour/article/view/131 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849249297437032448 |
|---|---|
| author | Yu. P. Smirnov |
| author_facet | Yu. P. Smirnov |
| author_sort | Yu. P. Smirnov |
| collection | DOAJ |
| description | The article overviews some theories of carcino- and leukemogenesis (viral, viralgenetic, viralimmunogenetic, immunological, polyetiological, chemical, mutational, hormonal, oncogenic, antiviral, embryonal, homotoxicological, of parasitic nature etc.). It summarizes some factors contributing to the emergence and development of carcino- and leukemogenesis. Mechanism of the development of leukemic pathology is described from the immunological standpoint. The importance of reducing the natural resistance of animals for raising the level of their infection with the BLV and the incidence of leukemia in infected individuals is shown. Immune protection of animals through the activation of T- and B-lymphocytes, phagocytes capable of killing tumor cells is pointed out. The role of interferons, interleukins in correction of defects of the immune system in response to the viral infection is noted. Advisability of application to young animals of immunotropic drugs activating cells of monocyte-macrophage systems to prevent leukemia is described. In case of a defect of the immune system circulating immune complexes are deposited in organs and contribute to their damage, particularly in ecologically unfavorable territories. The possibility of the immunoprophylaxis for preventing bovine leukemia by the administration of immunomodulators (ligphol, phosprenyl, E-selenium, anandin, selepher, ribotan etc.) particularly in combination stimulating immune reactions is shown. Immunomodulators contributed to increasing resistance of animals to BLV-infection. It is recommended to preserve the immune system activity on a sufficiently high level by using various effective immunomodulators particularly in combination for increasing effectiveness of anti-leukemia activities. |
| format | Article |
| id | doaj-art-98f9415d337b4d709cc52ae1ed35bf18 |
| institution | Kabale University |
| issn | 2072-9081 2500-1396 |
| language | Russian |
| publishDate | 2017-06-01 |
| publisher | Federal Agricultural Research Center of the North-East named N.V. Rudnitsky |
| record_format | Article |
| series | Аграрная наука Евро-Северо-Востока |
| spelling | doaj-art-98f9415d337b4d709cc52ae1ed35bf182025-08-20T03:57:36ZrusFederal Agricultural Research Center of the North-East named N.V. RudnitskyАграрная наука Евро-Северо-Востока2072-90812500-13962017-06-01034954130Theory of cancer and immunological aspects of carcinoand leukemogenesisYu. P. Smirnov0Scientific and Research Veterinary Institute of the Non-Chernozem Zone of the Russian FederationThe article overviews some theories of carcino- and leukemogenesis (viral, viralgenetic, viralimmunogenetic, immunological, polyetiological, chemical, mutational, hormonal, oncogenic, antiviral, embryonal, homotoxicological, of parasitic nature etc.). It summarizes some factors contributing to the emergence and development of carcino- and leukemogenesis. Mechanism of the development of leukemic pathology is described from the immunological standpoint. The importance of reducing the natural resistance of animals for raising the level of their infection with the BLV and the incidence of leukemia in infected individuals is shown. Immune protection of animals through the activation of T- and B-lymphocytes, phagocytes capable of killing tumor cells is pointed out. The role of interferons, interleukins in correction of defects of the immune system in response to the viral infection is noted. Advisability of application to young animals of immunotropic drugs activating cells of monocyte-macrophage systems to prevent leukemia is described. In case of a defect of the immune system circulating immune complexes are deposited in organs and contribute to their damage, particularly in ecologically unfavorable territories. The possibility of the immunoprophylaxis for preventing bovine leukemia by the administration of immunomodulators (ligphol, phosprenyl, E-selenium, anandin, selepher, ribotan etc.) particularly in combination stimulating immune reactions is shown. Immunomodulators contributed to increasing resistance of animals to BLV-infection. It is recommended to preserve the immune system activity on a sufficiently high level by using various effective immunomodulators particularly in combination for increasing effectiveness of anti-leukemia activities.https://www.agronauka-sv.ru/jour/article/view/131theories of carcinogenesisimmunological aspects of carcino-and leukemogenesisimmunological defectimmunocorrectionimmunomodulatorsblvimmunoprophylaxis |
| spellingShingle | Yu. P. Smirnov Theory of cancer and immunological aspects of carcinoand leukemogenesis Аграрная наука Евро-Северо-Востока theories of carcinogenesis immunological aspects of carcino-and leukemogenesis immunological defect immunocorrection immunomodulators blv immunoprophylaxis |
| title | Theory of cancer and immunological aspects of carcinoand leukemogenesis |
| title_full | Theory of cancer and immunological aspects of carcinoand leukemogenesis |
| title_fullStr | Theory of cancer and immunological aspects of carcinoand leukemogenesis |
| title_full_unstemmed | Theory of cancer and immunological aspects of carcinoand leukemogenesis |
| title_short | Theory of cancer and immunological aspects of carcinoand leukemogenesis |
| title_sort | theory of cancer and immunological aspects of carcinoand leukemogenesis |
| topic | theories of carcinogenesis immunological aspects of carcino-and leukemogenesis immunological defect immunocorrection immunomodulators blv immunoprophylaxis |
| url | https://www.agronauka-sv.ru/jour/article/view/131 |
| work_keys_str_mv | AT yupsmirnov theoryofcancerandimmunologicalaspectsofcarcinoandleukemogenesis |